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A genetic risk score is associated with statin-induced low-density lipoprotein cholesterol lowering

Leusink, Maarten and Maitland-van der Zee, Anke H and Ding, Bo and Drenos, Fotios and van Iperen, Erik PA and Warren, Helen R and Caulfield, Mark J and Cupples, L Adrienne and Cushman, Mary and Hingorani, Aroon D and Hoogeveen, Ron C and Hovingh, G Kees and Kumari, Meena and Lange, Leslie A and Munroe, Patricia B and Nyberg, Fredrik and Schreiner, Pamela J and Sivapalaratnam, Suthesh and de Bakker, Paul IW and de Boer, Anthonius and Keating, Brendan J and Asselbergs, Folkert W and Onland-Moret, N Charlotte (2016) 'A genetic risk score is associated with statin-induced low-density lipoprotein cholesterol lowering.' Pharmacogenomics, 17 (6). 583 - 591. ISSN 1462-2416

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Aim: To find new genetic loci associated with statin response, and to investigate the association of a genetic risk score (GRS) with this outcome. Patients & Methods: In a discovery meta-analysis (five studies, 1991 individuals), we investigated the effects of approximately 50000 single nucleotide polymorphisms on statin response, following up associations with p < 1 × 10(-4) (three independent studies, 5314 individuals). We further assessed the effect of a GRS based on SNPs in ABCG2, LPA and APOE. Results: No new SNPs were found associated with statin response. The GRS was associated with reduced statin response: 0.0394 mmol/l per allele (95% CI: 0.0171-0.0617, p = 5.37 × 10(-4)). Conclusion: The GRS was associated with statin response, but the small effect size (˜2% of the average low-density lipoprotein cholesterol reduction) limits applicability.

Item Type: Article
Uncontrolled Keywords: pharmacogenetics cholesterol, risk score, statin therapy
Subjects: H Social Sciences > H Social Sciences (General)
R Medicine > R Medicine (General)
Divisions: Faculty of Social Sciences > Institute for Social and Economic Research
Depositing User: Elements
Date Deposited: 23 Feb 2018 12:59
Last Modified: 09 Nov 2018 10:15

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