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Long working hours as a risk factor for atrial fibrillation: a multi-cohort study

Kivimäki, Mika and Nyberg, Solja T and Batty, G David and Kawachi, Ichiro and Jokela, Markus and Alfredsson, Lars and Bjorner, Jakob B and Borritz, Marianne and Burr, Hermann and Dragano, Nico and Fransson, Eleonor I and Heikkilä, Katriina and Knutsson, Anders and Koskenvuo, Markku and Kumari, Meena and Madsen, Ida EH and Nielsen, Martin L and Nordin, Maria and Oksanen, Tuula and Pejtersen, Jan H and Pentti, Jaana and Rugulies, Reiner and Salo, Paula and Shipley, Martin J and Suominen, Sakari and Theorell, Töres and Vahtera, Jussi and Westerholm, Peter and Westerlund, Hugo and Steptoe, Andrew and Singh-Manoux, Archana and Hamer, Mark and Ferrie, Jane E and Virtanen, Marianna and Tabak, Adam G (2017) 'Long working hours as a risk factor for atrial fibrillation: a multi-cohort study.' European Heart Journal, 38 (34). 2621 - 2628. ISSN 0195-668X

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Abstract

Aims: Studies suggest that people who work long hours are at increased risk of stroke, but the association of long working hours with atrial fibrillation, the most common cardiac arrhythmia and a risk factor for stroke, is unknown. We examined the risk of atrial fibrillation in individuals working long hours (≥55 per week) and those working standard 35–40h/week. Methods and results: In this prospective multi-cohort study from the Individual-Participant-Data Meta-analysis in Working Populations (IPD-Work) Consortium, the study population was 85,494 working men and women (mean age 43.4 years) with no recorded atrial fibrillation. Working hours were assessed at study baseline (1991–2004). Mean follow-up for incident atrial fibrillation was 10 years and cases were defined using data on electrocardiograms, hospital records, drug reimbursement registers, and death certificates. We identified 1061 new cases of atrial fibrillation (10-year cumulative incidence 12.4 per 1000). After adjustment for age, sex and socioeconomic status, individuals working long hours had a 1.4-fold increased risk of atrial fibrillation compared with those working standard hours (hazard ratio = 1.42, 95% CI = 1.13–1.80, P = 0.003). There was no significant heterogeneity between the cohort-specific effect estimates (I2 = 0%, P = 0.66) and the finding remained after excluding participants with coronary heart disease or stroke at baseline or during the follow-up (N = 2006, hazard ratio = 1.36, 95% CI = 1.05–1.76, P = 0.0180). Adjustment for potential confounding factors, such as obesity, risky alcohol use and high blood pressure, had little impact on this association. Conclusion: Individuals who worked long hours were more likely to develop atrial fibrillation than those working standard hours.

Item Type: Article
Subjects: H Social Sciences > H Social Sciences (General)
R Medicine > R Medicine (General)
Divisions: Faculty of Social Sciences > Institute for Social and Economic Research
Depositing User: Elements
Date Deposited: 06 Sep 2018 12:45
Last Modified: 06 Sep 2018 12:45
URI: http://repository.essex.ac.uk/id/eprint/22955

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