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On the causes of outliers in Affymetrix GeneChip data

Upton, GJG and Sanchez-Graillet, O and Rowsell, J and Arteaga-Salas, JM and Graham, NS and Stalteri, MA and Memon, FN and May, ST and Harrison, AP (2009) 'On the causes of outliers in Affymetrix GeneChip data.' Briefings in Functional Genomics and Proteomics, 8 (3). pp. 199-212. ISSN 1473-9550

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We describe various types of outliers seen in Affymetrix GeneChip data. We have been able to utilise the data in the Gene Expression Omnibus to screen GeneChips across a range of scales, from single probes, to spatially adjacent fractions of arrays, to whole arrays, to whole experiments. In this review we describe a number of causes for why some reported intensities might be misleading on GeneChips. © The Author 2009. Published by Oxford University Press.

Item Type: Article
Uncontrolled Keywords: Humans; DNA Probes; Artifacts; Oligonucleotide Array Sequence Analysis; Base Sequence; Molecular Sequence Data; Statistics as Topic
Subjects: Q Science > QA Mathematics
Q Science > QH Natural history > QH426 Genetics
Divisions: Faculty of Science and Health
Faculty of Science and Health > Mathematical Sciences, Department of
SWORD Depositor: Elements
Depositing User: Elements
Date Deposited: 06 Sep 2011 14:01
Last Modified: 15 Jan 2022 00:45

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