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Interaction between HLA-G and monocyte/macrophages in human pregnancy

Shakhawat, Ayesha and Shaikly, Valerie and Elzatma, Essam and Mavrakos, Emmanouil and Jabeen, Asma and Fernández, Nelson (2010) 'Interaction between HLA-G and monocyte/macrophages in human pregnancy.' Journal of Reproductive Immunology, 85 (1). pp. 40-46. ISSN 0165-0378

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Several lines of evidence suggest that the human leukocyte antigen (HLA)-G play a key role in the regulation of human pregnancy. A sub-population of cells highly represented at the decidua belong to the myeloid-derived monocyte/macrophage lineage, which potentially interact with HLA-G expressing cells. It is proposed that HLA-G protects decidual trophoblasts from lysis by blocking the effector function of decidual monocyte/macrophages. The interaction between HLA-G and monocyte/macrophages may therefore contribute to a successful pregnancy. Here we examine existing knowledge on the convergent role of HLA-G and monocyte/macrophages in pregnancy and define the synergy that exists between these two elements in the decidua. Key features of the HLA-G gene product are discussed followed by the main characteristics of decidual monocyte/macrophages. A hypothetical model for the interaction between HLA-G and monocyte/macrophage cells at the fetal-maternal interface is proposed. © 2010 Elsevier Ireland Ltd.

Item Type: Article
Uncontrolled Keywords: Pregnancy; HLA-G; Decidua; Monocyte/macrophages; ILT inhibitors; Natural killer cells
Subjects: Q Science > QH Natural history > QH301 Biology
Divisions: Faculty of Science and Health
Faculty of Science and Health > Life Sciences, School of
SWORD Depositor: Elements
Depositing User: Elements
Date Deposited: 15 Sep 2011 12:33
Last Modified: 18 Aug 2022 10:59

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