Shakhawat, Ayesha and Shaikly, Valerie and Elzatma, Essam and Mavrakos, Emmanouil and Jabeen, Asma and Fernández, Nelson (2010) Interaction between HLA-G and monocyte/macrophages in human pregnancy. Journal of Reproductive Immunology, 85 (1). pp. 40-46. DOI https://doi.org/10.1016/j.jri.2010.02.004
Shakhawat, Ayesha and Shaikly, Valerie and Elzatma, Essam and Mavrakos, Emmanouil and Jabeen, Asma and Fernández, Nelson (2010) Interaction between HLA-G and monocyte/macrophages in human pregnancy. Journal of Reproductive Immunology, 85 (1). pp. 40-46. DOI https://doi.org/10.1016/j.jri.2010.02.004
Shakhawat, Ayesha and Shaikly, Valerie and Elzatma, Essam and Mavrakos, Emmanouil and Jabeen, Asma and Fernández, Nelson (2010) Interaction between HLA-G and monocyte/macrophages in human pregnancy. Journal of Reproductive Immunology, 85 (1). pp. 40-46. DOI https://doi.org/10.1016/j.jri.2010.02.004
Abstract
Several lines of evidence suggest that the human leukocyte antigen (HLA)-G play a key role in the regulation of human pregnancy. A sub-population of cells highly represented at the decidua belong to the myeloid-derived monocyte/macrophage lineage, which potentially interact with HLA-G expressing cells. It is proposed that HLA-G protects decidual trophoblasts from lysis by blocking the effector function of decidual monocyte/macrophages. The interaction between HLA-G and monocyte/macrophages may therefore contribute to a successful pregnancy. Here we examine existing knowledge on the convergent role of HLA-G and monocyte/macrophages in pregnancy and define the synergy that exists between these two elements in the decidua. Key features of the HLA-G gene product are discussed followed by the main characteristics of decidual monocyte/macrophages. A hypothetical model for the interaction between HLA-G and monocyte/macrophage cells at the fetal-maternal interface is proposed. © 2010 Elsevier Ireland Ltd.
Item Type: | Article |
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Uncontrolled Keywords: | Pregnancy; HLA-G; Decidua; Monocyte/macrophages; ILT inhibitors; Natural killer cells |
Subjects: | Q Science > QH Natural history > QH301 Biology |
Divisions: | Faculty of Science and Health Faculty of Science and Health > Life Sciences, School of |
SWORD Depositor: | Unnamed user with email elements@essex.ac.uk |
Depositing User: | Unnamed user with email elements@essex.ac.uk |
Date Deposited: | 15 Sep 2011 12:33 |
Last Modified: | 30 Oct 2024 19:42 |
URI: | http://repository.essex.ac.uk/id/eprint/711 |