Fiori, Francesca and Chiappini, Emilio and Soriano, Marco and Paracampo, Riccardo and Romei, Vincenzo and Borgomaneri, Sara and Avenanti, Alessio (2016) Long-latency modulation of motor cortex excitability by ipsilateral posterior inferior frontal gyrus and pre-supplementary motor area. Scientific Reports, 6 (1). 38396-. DOI https://doi.org/10.1038/srep38396
Fiori, Francesca and Chiappini, Emilio and Soriano, Marco and Paracampo, Riccardo and Romei, Vincenzo and Borgomaneri, Sara and Avenanti, Alessio (2016) Long-latency modulation of motor cortex excitability by ipsilateral posterior inferior frontal gyrus and pre-supplementary motor area. Scientific Reports, 6 (1). 38396-. DOI https://doi.org/10.1038/srep38396
Fiori, Francesca and Chiappini, Emilio and Soriano, Marco and Paracampo, Riccardo and Romei, Vincenzo and Borgomaneri, Sara and Avenanti, Alessio (2016) Long-latency modulation of motor cortex excitability by ipsilateral posterior inferior frontal gyrus and pre-supplementary motor area. Scientific Reports, 6 (1). 38396-. DOI https://doi.org/10.1038/srep38396
Abstract
<jats:title>Abstract</jats:title><jats:p>The primary motor cortex (M1) is strongly influenced by several frontal regions. Dual-site transcranial magnetic stimulation (dsTMS) has highlighted the timing of early (<40 ms) prefrontal/premotor influences over M1. Here we used dsTMS to investigate, for the first time, longer-latency causal interactions of the posterior inferior frontal gyrus (pIFG) and pre-supplementary motor area (pre-SMA) with M1 at rest. A suprathreshold test stimulus (TS) was applied over M1 producing a motor-evoked potential (MEP) in the relaxed hand. Either a subthreshold or a suprathreshold conditioning stimulus (CS) was administered over ipsilateral pIFG/pre-SMA sites before the TS at different CS-TS inter-stimulus intervals (ISIs: 40–150 ms). Independently of intensity, CS over pIFG and pre-SMA (but not over a control site) inhibited MEPs at an ISI of 40 ms. The CS over pIFG produced a second peak of inhibition at an ISI of 150 ms. Additionally, facilitatory modulations were found at an ISI of 60 ms, with supra- but not subthreshold CS intensities. These findings suggest differential modulatory roles of pIFG and pre-SMA in M1 excitability. In particular, the pIFG –but not the pre-SMA– exerts intensity-dependent modulatory influences over M1 within the explored time window of 40-150 ms, evidencing fine-tuned control of M1 output.</jats:p>
Item Type: | Article |
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Uncontrolled Keywords: | Hand; Motor Cortex; Prefrontal Cortex; Humans; Brain Mapping; Evoked Potentials, Motor; Rest; Adult; Female; Male; Transcranial Magnetic Stimulation; Functional Laterality |
Subjects: | R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry |
Divisions: | Faculty of Science and Health Faculty of Science and Health > Psychology, Department of |
SWORD Depositor: | Unnamed user with email elements@essex.ac.uk |
Depositing User: | Unnamed user with email elements@essex.ac.uk |
Date Deposited: | 06 Feb 2017 18:02 |
Last Modified: | 30 Oct 2024 20:22 |
URI: | http://repository.essex.ac.uk/id/eprint/19014 |
Available files
Filename: srep38396.pdf
Licence: Creative Commons: Attribution 3.0