Cole, JH and Filippetti, ML and Allin, MPG and Walshe, M and Nam, KW and Gutman, BA and Murray, RM and Rifkin, L and Thompson, PM and Nosarti, C (2015) Subregional hippocampal morphology and psychiatric outcome in adolescents who were born very preterm and at term. PLoS ONE, 10 (6). e0130094-e0130094. DOI https://doi.org/10.1371/journal.pone.0130094
Cole, JH and Filippetti, ML and Allin, MPG and Walshe, M and Nam, KW and Gutman, BA and Murray, RM and Rifkin, L and Thompson, PM and Nosarti, C (2015) Subregional hippocampal morphology and psychiatric outcome in adolescents who were born very preterm and at term. PLoS ONE, 10 (6). e0130094-e0130094. DOI https://doi.org/10.1371/journal.pone.0130094
Cole, JH and Filippetti, ML and Allin, MPG and Walshe, M and Nam, KW and Gutman, BA and Murray, RM and Rifkin, L and Thompson, PM and Nosarti, C (2015) Subregional hippocampal morphology and psychiatric outcome in adolescents who were born very preterm and at term. PLoS ONE, 10 (6). e0130094-e0130094. DOI https://doi.org/10.1371/journal.pone.0130094
Abstract
Background: The hippocampus has been reported to be structurally and functionally altered as a sequel of very preterm birth ( < 33 weeks gestation), possibly due its vulnerability to hypoxic-ischemic damage in the neonatal period. We examined hippocampal volumes and subregional morphology in very preterm born individuals in mid- and late adolescence and their association with psychiatric outcome. Methods: Structural brain magnetic resonance images were acquired at two time points (baseline and follow-up) from 65 ex-preterm adolescents (mean age = 15.5 and 19.6 years) and 36 termborn controls (mean age=15.0 and 19.0 years). Hippocampal volumes and subregional morphometric differences were measured from manual tracings and with three-dimensional shape analysis. Psychiatric outcome was assessed with the Rutter Parents' Scale at baseline, the General Health Questionnaire at follow-up and the Peters Delusional Inventory at both time points. Results: In contrast to previous studies we did not find significant difference in the cross-sectional or longitudinal hippocampal volumes between individuals born preterm and controls, despite preterm individual having significantly smaller whole brain volumes. Shape analysis at baseline revealed subregional deformations in 28% of total bilateral hippocampal surface, reflecting atrophy, in ex-preterm individuals compared to controls, and in 22% at follow-up. In ex-preterm individuals, longitudinal changes in hippocampal shape accounted for 11% of the total surface, while in controls they reached 20%. In the whole sample (both groups) larger right hippocampal volume and bilateral anterior surface deformations at baseline were associated with delusional ideation scores at follow-up. Conclusions: This study suggests a dynamic association between cross-sectional hippocampal volumes, longitudinal changes and surface deformations and psychosis proneness. Copyright:
Item Type: | Article |
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Uncontrolled Keywords: | Hippocampus; Humans; Premature Birth; Organ Size; Case-Control Studies; Follow-Up Studies; Adolescent Behavior; Delusions; Psychotic Disorders; Gestational Age; Adolescent; Infant, Newborn; Infant, Premature; Young Adult |
Subjects: | R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry |
Divisions: | Faculty of Science and Health Faculty of Science and Health > Psychology, Department of |
SWORD Depositor: | Unnamed user with email elements@essex.ac.uk |
Depositing User: | Unnamed user with email elements@essex.ac.uk |
Date Deposited: | 06 Oct 2017 13:00 |
Last Modified: | 30 Oct 2024 16:34 |
URI: | http://repository.essex.ac.uk/id/eprint/20435 |
Available files
Filename: journal.pone.0130094.PDF
Licence: Creative Commons: Attribution 3.0