Dong, Yue and Lin, Hungyen and Abolghasemi, Vahid and Gan, Lu and Zeitler, J Axel and Shen, Yao-Chun (2017) Investigating Intra-Tablet Coating Uniformity With Spectral-Domain Optical Coherence Tomography. Journal of Pharmaceutical Sciences, 106 (2). pp. 546-553. DOI https://doi.org/10.1016/j.xphs.2016.09.021
Dong, Yue and Lin, Hungyen and Abolghasemi, Vahid and Gan, Lu and Zeitler, J Axel and Shen, Yao-Chun (2017) Investigating Intra-Tablet Coating Uniformity With Spectral-Domain Optical Coherence Tomography. Journal of Pharmaceutical Sciences, 106 (2). pp. 546-553. DOI https://doi.org/10.1016/j.xphs.2016.09.021
Dong, Yue and Lin, Hungyen and Abolghasemi, Vahid and Gan, Lu and Zeitler, J Axel and Shen, Yao-Chun (2017) Investigating Intra-Tablet Coating Uniformity With Spectral-Domain Optical Coherence Tomography. Journal of Pharmaceutical Sciences, 106 (2). pp. 546-553. DOI https://doi.org/10.1016/j.xphs.2016.09.021
Abstract
Spectral domain optical coherence tomography (SD-OCT) has recently attracted a lot of interest in the pharmaceutical industry as a fast and non-destructive modality for direct quantification of thin film coatings that cannot easily be resolved with other techniques. While previous studies with SD-OCT have estimated the intra-tablet coating uniformity, the estimates were based on limited number of B-scans. In order to obtain a more accurate estimate, a greater number of B-scans are required that can quickly lead to an overwhelming amount of data. To better manage the data so as to generate a more accurate representation of the intra-tablet coating uniformity without compromising on the achievable axial resolution and imaging depth, we comprehensively examine an algebraic reconstruction technique with OCT to significantly reduce the data required. Specifically, a set of coated pharmaceutical tablets with film coating thickness in the range of 60-100 μm is investigated. Results obtained from performing the reconstruction reveal that only 30% of the acquired data are actually required leading to a faster convergence time and a generally good agreement with benchmark data against the intra-tablet coating uniformity measured with terahertz pulsed imaging technology.
Item Type: | Article |
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Uncontrolled Keywords: | coating; optical coherence tomography; imaging method; process analytical technology; tablet |
Divisions: | Faculty of Science and Health Faculty of Science and Health > Computer Science and Electronic Engineering, School of |
SWORD Depositor: | Unnamed user with email elements@essex.ac.uk |
Depositing User: | Unnamed user with email elements@essex.ac.uk |
Date Deposited: | 23 Apr 2020 13:36 |
Last Modified: | 30 Oct 2024 17:10 |
URI: | http://repository.essex.ac.uk/id/eprint/27071 |
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