Fitzgerald, Paul B and Daskalakis, Zafiris J and Hoy, Kate and Farzan, Faranak and Upton, Daniel J and Cooper, Nicholas R and Maller, Jerome J (2008) Cortical Inhibition in Motor and Non-Motor Regions: A Combined TMS-EEG Study. Clinical EEG and Neuroscience, 39 (3). pp. 112-117. DOI https://doi.org/10.1177/155005940803900304
Fitzgerald, Paul B and Daskalakis, Zafiris J and Hoy, Kate and Farzan, Faranak and Upton, Daniel J and Cooper, Nicholas R and Maller, Jerome J (2008) Cortical Inhibition in Motor and Non-Motor Regions: A Combined TMS-EEG Study. Clinical EEG and Neuroscience, 39 (3). pp. 112-117. DOI https://doi.org/10.1177/155005940803900304
Fitzgerald, Paul B and Daskalakis, Zafiris J and Hoy, Kate and Farzan, Faranak and Upton, Daniel J and Cooper, Nicholas R and Maller, Jerome J (2008) Cortical Inhibition in Motor and Non-Motor Regions: A Combined TMS-EEG Study. Clinical EEG and Neuroscience, 39 (3). pp. 112-117. DOI https://doi.org/10.1177/155005940803900304
Abstract
<jats:p> A number of studies using paired pulse transcranial magnetic stimulation (TMS) have demonstrated that cortical inhibition (CI) of the motor cortex can be recorded and also gauged through surface electromyography. However, recording CI from other brain regions that are more directly related with the pathophysiology of some neurologic and psychiatric disorders (e.g., dorsolateral prefrontal cortex (DLPFC) in schizophrenia) was previously fraught with technical difficulties. This study was therefore designed to examine, through a combination of TMS with EEG, whether CI could be measured directly from the motor cortex, DLPFC, and another non-motor region. </jats:p><jats:p> To index CI, long interval cortical inhibition (LICI; a TMS paradigm) was used in the motor cortex and DLPFC in 14 healthy subjects, and in the parietal lobe in 5 of those subjects. In the motor cortex, LICI resulted in a significant suppression in mean cortical evoked activity on EEG (37.31 ± 47.51 %). In the DLPFC, LICI resulted in a significant suppression (32.45 ± 47.86 %) in mean cortical evoked activity and did not correlate with LICI in the motor cortex although they did not significantly differ. In the parietal lobe, LICI resulted in significant suppression (47.76 ± 44.70 %) in mean cortical evoked activity. </jats:p><jats:p> In conclusion, CI in the dorsolateral prefrontal cortex, motor cortex and parietal cortex were similar at 120% of motor threshold. These data suggest that CI can be recorded by combining TMS with EEG and may facilitate future research attempting to ascertain the role of CI in the pathophysiology of several neurologic and psychiatric disorders. </jats:p>
Item Type: | Article |
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Uncontrolled Keywords: | cortical inhibition; dorsolateral prefrontal cortex; electroencephalography; GABA(B) receptor; motor cortex; parietal cortex; transcranial magnetic stimulation |
Subjects: | B Philosophy. Psychology. Religion > BF Psychology R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry |
Divisions: | Faculty of Science and Health Faculty of Science and Health > Psychology, Department of |
SWORD Depositor: | Unnamed user with email elements@essex.ac.uk |
Depositing User: | Unnamed user with email elements@essex.ac.uk |
Date Deposited: | 06 Jul 2012 12:44 |
Last Modified: | 30 Oct 2024 19:39 |
URI: | http://repository.essex.ac.uk/id/eprint/2816 |