Dabrowska, Aleksandra and Kumar, Juhi and Rallis, Charalampos (2022) Nutrient-Response Pathways in Healthspan and Lifespan Regulation. Cells, 11 (9). p. 1568. DOI https://doi.org/10.3390/cells11091568
Dabrowska, Aleksandra and Kumar, Juhi and Rallis, Charalampos (2022) Nutrient-Response Pathways in Healthspan and Lifespan Regulation. Cells, 11 (9). p. 1568. DOI https://doi.org/10.3390/cells11091568
Dabrowska, Aleksandra and Kumar, Juhi and Rallis, Charalampos (2022) Nutrient-Response Pathways in Healthspan and Lifespan Regulation. Cells, 11 (9). p. 1568. DOI https://doi.org/10.3390/cells11091568
Abstract
Cellular, small invertebrate and vertebrate models are a driving force in biogerontology studies. Using various models, such as yeasts, appropriate tissue culture cells, Drosophila, the nematode Caenorhabditis elegans and the mouse, has tremendously increased our knowledge around the relationship between diet, nutrient-response signaling pathways and lifespan regulation. In recent years, combinatorial drug treatments combined with mutagenesis, high-throughput screens, as well as multi-omics approaches, have provided unprecedented insights in cellular metabolism, development, differentiation, and aging. Scientists are, therefore, moving towards characterizing the fine architecture and cross-talks of growth and stress pathways towards identifying possible interventions that could lead to healthy aging and the amelioration of age-related diseases in humans. In this short review, we briefly examine recently uncovered knowledge around nutrient-response pathways, such as the Insulin Growth Factor (IGF) and the mechanistic Target of Rapamycin signaling pathways, as well as specific GWAS and some EWAS studies on lifespan and age-related disease that have enhanced our current understanding within the aging and biogerontology fields. We discuss what is learned from the rich and diverse generated data, as well as challenges and next frontiers in these scientific disciplines.
Item Type: | Article |
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Uncontrolled Keywords: | Drosophila melanogaster; Caenorhabditis elegans; mouse; yeast; translation; transcriptome; proteome; metabolome; TORC1; IGF-1; GWAS; EWAS |
Divisions: | Faculty of Science and Health Faculty of Science and Health > Life Sciences, School of |
SWORD Depositor: | Unnamed user with email elements@essex.ac.uk |
Depositing User: | Unnamed user with email elements@essex.ac.uk |
Date Deposited: | 20 Jun 2022 15:21 |
Last Modified: | 30 Oct 2024 19:32 |
URI: | http://repository.essex.ac.uk/id/eprint/32829 |
Available files
Filename: cells-11-01568-v2.pdf
Licence: Creative Commons: Attribution 3.0