Lammi, Vilma and Nakanishi, Tomoko and Jones, Samuel E and Andrews, Shea J and Karjalainen, Juha and Cortés, Beatriz and O’Brien, Heath E and Fulton-Howard, Brian E and Haapaniemi, Hele H and Schmidt, Axel and Mitchell, Ruth E and Mousas, Abdou and Mangino, Massimo and Huerta-Chagoya, Alicia and Sinnott-Armstrong, Nasa and Cirulli, Elizabeth T and Vaudel, Marc and Kwong, Alex SF and Maiti, Amit K and Marttila, Minttu and Batini, Chiara and Minnai, Francesca and Dearman, Anna R and Warmerdam, CA Robert and Sequeros, Celia B and Winkler, Thomas W and Jordan, Daniel M and Guare, Lindsay and Vergasova, Ekaterina and Marouli, Eirini and Striano, Pasquale and Zainulabid, Ummu Afeera and Kumar, Ashutosh and Ahmad, Hajar Fauzan and Edahiro, Ryuya and Azekawa, Shuhei and Grzymski, Joseph J and Ishii, Makoto and Okada, Yukinori and Beckmann, Noam D and Kumari, Meena and Wagner, Ralf and Heid, Iris M and John, Catherine and Short, Patrick J and Magnus, Per and Banasik, Karina and Geller, Frank and Franke, Lude H and Rakitko, Alexander and Duncan, Emma L and Renieri, Alessandra and Tsilidis, Konstantinos K and de Cid, Rafael and Niavarani, Ahmadreza and Tusié-Luna, Teresa and Verma, Shefali S and Smith, George Davey and Timpson, Nicholas J and Daly, Mark J and Ganna, Andrea and Schulte, Eva C and Richards, J Brent and Ludwig, Kerstin U and Hultström, Michael and Zeberg, Hugo and Ollila, Hanna M (2023) Genome-wide Association Study of Long COVID. Working Paper. medRxiv.
Lammi, Vilma and Nakanishi, Tomoko and Jones, Samuel E and Andrews, Shea J and Karjalainen, Juha and Cortés, Beatriz and O’Brien, Heath E and Fulton-Howard, Brian E and Haapaniemi, Hele H and Schmidt, Axel and Mitchell, Ruth E and Mousas, Abdou and Mangino, Massimo and Huerta-Chagoya, Alicia and Sinnott-Armstrong, Nasa and Cirulli, Elizabeth T and Vaudel, Marc and Kwong, Alex SF and Maiti, Amit K and Marttila, Minttu and Batini, Chiara and Minnai, Francesca and Dearman, Anna R and Warmerdam, CA Robert and Sequeros, Celia B and Winkler, Thomas W and Jordan, Daniel M and Guare, Lindsay and Vergasova, Ekaterina and Marouli, Eirini and Striano, Pasquale and Zainulabid, Ummu Afeera and Kumar, Ashutosh and Ahmad, Hajar Fauzan and Edahiro, Ryuya and Azekawa, Shuhei and Grzymski, Joseph J and Ishii, Makoto and Okada, Yukinori and Beckmann, Noam D and Kumari, Meena and Wagner, Ralf and Heid, Iris M and John, Catherine and Short, Patrick J and Magnus, Per and Banasik, Karina and Geller, Frank and Franke, Lude H and Rakitko, Alexander and Duncan, Emma L and Renieri, Alessandra and Tsilidis, Konstantinos K and de Cid, Rafael and Niavarani, Ahmadreza and Tusié-Luna, Teresa and Verma, Shefali S and Smith, George Davey and Timpson, Nicholas J and Daly, Mark J and Ganna, Andrea and Schulte, Eva C and Richards, J Brent and Ludwig, Kerstin U and Hultström, Michael and Zeberg, Hugo and Ollila, Hanna M (2023) Genome-wide Association Study of Long COVID. Working Paper. medRxiv.
Lammi, Vilma and Nakanishi, Tomoko and Jones, Samuel E and Andrews, Shea J and Karjalainen, Juha and Cortés, Beatriz and O’Brien, Heath E and Fulton-Howard, Brian E and Haapaniemi, Hele H and Schmidt, Axel and Mitchell, Ruth E and Mousas, Abdou and Mangino, Massimo and Huerta-Chagoya, Alicia and Sinnott-Armstrong, Nasa and Cirulli, Elizabeth T and Vaudel, Marc and Kwong, Alex SF and Maiti, Amit K and Marttila, Minttu and Batini, Chiara and Minnai, Francesca and Dearman, Anna R and Warmerdam, CA Robert and Sequeros, Celia B and Winkler, Thomas W and Jordan, Daniel M and Guare, Lindsay and Vergasova, Ekaterina and Marouli, Eirini and Striano, Pasquale and Zainulabid, Ummu Afeera and Kumar, Ashutosh and Ahmad, Hajar Fauzan and Edahiro, Ryuya and Azekawa, Shuhei and Grzymski, Joseph J and Ishii, Makoto and Okada, Yukinori and Beckmann, Noam D and Kumari, Meena and Wagner, Ralf and Heid, Iris M and John, Catherine and Short, Patrick J and Magnus, Per and Banasik, Karina and Geller, Frank and Franke, Lude H and Rakitko, Alexander and Duncan, Emma L and Renieri, Alessandra and Tsilidis, Konstantinos K and de Cid, Rafael and Niavarani, Ahmadreza and Tusié-Luna, Teresa and Verma, Shefali S and Smith, George Davey and Timpson, Nicholas J and Daly, Mark J and Ganna, Andrea and Schulte, Eva C and Richards, J Brent and Ludwig, Kerstin U and Hultström, Michael and Zeberg, Hugo and Ollila, Hanna M (2023) Genome-wide Association Study of Long COVID. Working Paper. medRxiv.
Abstract
<jats:title>Summary</jats:title><jats:p>Infections can lead to persistent or long-term symptoms and diseases such as shingles after varicella zoster, cancers after human papillomavirus, or rheumatic fever after streptococcal infections<jats:sup>1, 2</jats:sup>. Similarly, infection by SARS-CoV-2 can result in Long COVID, a condition characterized by symptoms of fatigue and pulmonary and cognitive dysfunction<jats:sup>3–5</jats:sup>. The biological mechanisms that contribute to the development of Long COVID remain to be clarified. We leveraged the COVID-19 Host Genetics Initiative<jats:sup>6, 7</jats:sup>to perform a genome-wide association study for Long COVID including up to 6,450 Long COVID cases and 1,093,995 population controls from 24 studies across 16 countries. We identified the first genome-wide significant association for Long COVID at the<jats:italic>FOXP4</jats:italic>locus.<jats:italic>FOXP4</jats:italic>has been previously associated with COVID-19 severity<jats:sup>6</jats:sup>, lung function<jats:sup>8</jats:sup>, and cancers<jats:sup>9</jats:sup>, suggesting a broader role for lung function in the pathophysiology of Long COVID. While we identify COVID-19 severity as a causal risk factor for Long COVID, the impact of the genetic risk factor located in the<jats:italic>FOXP4</jats:italic>locus could not be solely explained by its association to severe COVID-19. Our findings further support the role of pulmonary dysfunction and COVID-19 severity in the development of Long COVID.</jats:p>
| Item Type: | Monograph (Working Paper) |
|---|---|
| Divisions: | Faculty of Social Sciences Faculty of Social Sciences > Institute for Social and Economic Research |
| SWORD Depositor: | Unnamed user with email elements@essex.ac.uk |
| Depositing User: | Unnamed user with email elements@essex.ac.uk |
| Date Deposited: | 24 Jul 2023 09:07 |
| Last Modified: | 28 Oct 2024 10:24 |
| URI: | http://repository.essex.ac.uk/id/eprint/36047 |
Available files
Filename: 2023.06.29.23292056v1.full.pdf
Licence: Creative Commons: Attribution-Noncommercial 4.0