Carrillo-Larco, Rodrigo M and Stern, Dalia and Hambleton, Ian R and Hennis, Anselm and Cesare, Mariachiara Di and Lotufo, Paulo and Ferreccio, Catterina and Irazola, Vilma and Perel, Pablo and Gregg, Edward W and Miranda, J Jaime and Ezzati, Majid and Danaei, Goodarz and Aguilar-Salinas, Carlos A and Alvarez-Váz, Ramón and Amadio, Marselle B and Baccino, Cecilia and Bambs, Claudia and Bastos, João Luiz and Beckles, Gloria and Bernabe-Ortiz, Antonio and Bernardo, Carla DO and Bloch, Katia V and Blümel, Juan E and Boggia, Jose G and Borges, Pollyanna K and Bravo, Miguel and Brenes-Camacho, Gilbert and Carbajal, Horacio A and Rascon, Maria S Castillo and Ceballos, Blanca H and Colpani, Veronica and Cooper, Jackie A and Cortes, Sandra and Cortes-Valencia, Adrian and Cunha, Roberto S and d'Orsi, Eleonora and Dow, William H and Espeche, Walter G and Fuchs, Flavio D and Fuchs, Sandra C and Gimeno, Suely GA and Gomez-Velasco, Donaji and Gonzalez-Chica, David A and Gonzalez-Villalpando, Clicerio and Gonzalez-Villalpando, María-Elena and Grazioli, Gonzalo and Guerra, Ricardo O and Gutierrez, Laura and Herkenhoff, Fernando L and Horimoto, Andrea RVR and Huidobro, Andrea and Koch, Elard and Lajous, Martin and Lima-Costa, Maria Fernanda and Lopez-Ridaura, Ruy and Maciel, Alvaro CC and Manrique-Espinoza, Betty S and Marques, Larissa P and Mill, Jose G and Moreira, Leila B and Muñoz, Oscar M and Ono, Lariane M and Oppermann, Karen and Paiva, Karina M and Peixoto, Sergio V and Pereira, Alexandre C and Peres, Karen G and Peres, Marco A and Ramírez-Palacios, Paula and Rech, Cassiano R and Rivera-Paredez, Berenice and Rodriguez, Nohora I and Rojas-Martinez, Rosalba and Rosero-Bixby, Luis and Rubinstein, Adolfo and Ruiz-Morales, Alvaro and Salazar, Martin R and Salinas-Rodriguez, Aaron and Salmerón, Jorge and Sanchez, Ramon A and Silva, Nelson AS and Silva, Thiago LN and Smeeth, Liam and Spritzer, Poli M and Tartaglione, Fiorella and Tartaglione, Jorge and Velázquez-Cruz, Rafael (2021) Impact of common cardio-metabolic risk factors on fatal and non-fatal cardiovascular disease in Latin America and the Caribbean: an individual-level pooled analysis of 31 cohort studies. The Lancet Regional Health - Americas, 4. DOI https://doi.org/10.1016/j.lana.2021.100068
Carrillo-Larco, Rodrigo M and Stern, Dalia and Hambleton, Ian R and Hennis, Anselm and Cesare, Mariachiara Di and Lotufo, Paulo and Ferreccio, Catterina and Irazola, Vilma and Perel, Pablo and Gregg, Edward W and Miranda, J Jaime and Ezzati, Majid and Danaei, Goodarz and Aguilar-Salinas, Carlos A and Alvarez-Váz, Ramón and Amadio, Marselle B and Baccino, Cecilia and Bambs, Claudia and Bastos, João Luiz and Beckles, Gloria and Bernabe-Ortiz, Antonio and Bernardo, Carla DO and Bloch, Katia V and Blümel, Juan E and Boggia, Jose G and Borges, Pollyanna K and Bravo, Miguel and Brenes-Camacho, Gilbert and Carbajal, Horacio A and Rascon, Maria S Castillo and Ceballos, Blanca H and Colpani, Veronica and Cooper, Jackie A and Cortes, Sandra and Cortes-Valencia, Adrian and Cunha, Roberto S and d'Orsi, Eleonora and Dow, William H and Espeche, Walter G and Fuchs, Flavio D and Fuchs, Sandra C and Gimeno, Suely GA and Gomez-Velasco, Donaji and Gonzalez-Chica, David A and Gonzalez-Villalpando, Clicerio and Gonzalez-Villalpando, María-Elena and Grazioli, Gonzalo and Guerra, Ricardo O and Gutierrez, Laura and Herkenhoff, Fernando L and Horimoto, Andrea RVR and Huidobro, Andrea and Koch, Elard and Lajous, Martin and Lima-Costa, Maria Fernanda and Lopez-Ridaura, Ruy and Maciel, Alvaro CC and Manrique-Espinoza, Betty S and Marques, Larissa P and Mill, Jose G and Moreira, Leila B and Muñoz, Oscar M and Ono, Lariane M and Oppermann, Karen and Paiva, Karina M and Peixoto, Sergio V and Pereira, Alexandre C and Peres, Karen G and Peres, Marco A and Ramírez-Palacios, Paula and Rech, Cassiano R and Rivera-Paredez, Berenice and Rodriguez, Nohora I and Rojas-Martinez, Rosalba and Rosero-Bixby, Luis and Rubinstein, Adolfo and Ruiz-Morales, Alvaro and Salazar, Martin R and Salinas-Rodriguez, Aaron and Salmerón, Jorge and Sanchez, Ramon A and Silva, Nelson AS and Silva, Thiago LN and Smeeth, Liam and Spritzer, Poli M and Tartaglione, Fiorella and Tartaglione, Jorge and Velázquez-Cruz, Rafael (2021) Impact of common cardio-metabolic risk factors on fatal and non-fatal cardiovascular disease in Latin America and the Caribbean: an individual-level pooled analysis of 31 cohort studies. The Lancet Regional Health - Americas, 4. DOI https://doi.org/10.1016/j.lana.2021.100068
Carrillo-Larco, Rodrigo M and Stern, Dalia and Hambleton, Ian R and Hennis, Anselm and Cesare, Mariachiara Di and Lotufo, Paulo and Ferreccio, Catterina and Irazola, Vilma and Perel, Pablo and Gregg, Edward W and Miranda, J Jaime and Ezzati, Majid and Danaei, Goodarz and Aguilar-Salinas, Carlos A and Alvarez-Váz, Ramón and Amadio, Marselle B and Baccino, Cecilia and Bambs, Claudia and Bastos, João Luiz and Beckles, Gloria and Bernabe-Ortiz, Antonio and Bernardo, Carla DO and Bloch, Katia V and Blümel, Juan E and Boggia, Jose G and Borges, Pollyanna K and Bravo, Miguel and Brenes-Camacho, Gilbert and Carbajal, Horacio A and Rascon, Maria S Castillo and Ceballos, Blanca H and Colpani, Veronica and Cooper, Jackie A and Cortes, Sandra and Cortes-Valencia, Adrian and Cunha, Roberto S and d'Orsi, Eleonora and Dow, William H and Espeche, Walter G and Fuchs, Flavio D and Fuchs, Sandra C and Gimeno, Suely GA and Gomez-Velasco, Donaji and Gonzalez-Chica, David A and Gonzalez-Villalpando, Clicerio and Gonzalez-Villalpando, María-Elena and Grazioli, Gonzalo and Guerra, Ricardo O and Gutierrez, Laura and Herkenhoff, Fernando L and Horimoto, Andrea RVR and Huidobro, Andrea and Koch, Elard and Lajous, Martin and Lima-Costa, Maria Fernanda and Lopez-Ridaura, Ruy and Maciel, Alvaro CC and Manrique-Espinoza, Betty S and Marques, Larissa P and Mill, Jose G and Moreira, Leila B and Muñoz, Oscar M and Ono, Lariane M and Oppermann, Karen and Paiva, Karina M and Peixoto, Sergio V and Pereira, Alexandre C and Peres, Karen G and Peres, Marco A and Ramírez-Palacios, Paula and Rech, Cassiano R and Rivera-Paredez, Berenice and Rodriguez, Nohora I and Rojas-Martinez, Rosalba and Rosero-Bixby, Luis and Rubinstein, Adolfo and Ruiz-Morales, Alvaro and Salazar, Martin R and Salinas-Rodriguez, Aaron and Salmerón, Jorge and Sanchez, Ramon A and Silva, Nelson AS and Silva, Thiago LN and Smeeth, Liam and Spritzer, Poli M and Tartaglione, Fiorella and Tartaglione, Jorge and Velázquez-Cruz, Rafael (2021) Impact of common cardio-metabolic risk factors on fatal and non-fatal cardiovascular disease in Latin America and the Caribbean: an individual-level pooled analysis of 31 cohort studies. The Lancet Regional Health - Americas, 4. DOI https://doi.org/10.1016/j.lana.2021.100068
Abstract
Background: Estimates of the burden of cardio-metabolic risk factors in Latin America and the Caribbean (LAC) rely on relative risks (RRs) from non-LAC countries. Whether these RRs apply to LAC remains unknown. Methods: We pooled LAC cohorts. We estimated RRs per unit of exposure to body mass index (BMI), systolic blood pressure (SBP), fasting plasma glucose (FPG), total cholesterol (TC) and non-HDL cholesterol on fatal (31 cohorts, n=168,287) and non-fatal (13 cohorts, n=27,554) cardiovascular diseases, adjusting for regression dilution bias. We used these RRs and national data on mean risk factor levels to estimate the number of cardiovascular deaths attributable to non-optimal levels of each risk factor. Results: Our RRs for SBP, FPG and TC were like those observed in cohorts conducted in high-income countries; however, for BMI, our RRs were consistently smaller in people below 75 years of age. Across risk factors, we observed smaller RRs among older ages. Non-optimal SBP was responsible for the largest number of attributable cardiovascular deaths ranging from 38 per 100,000 women and 54 men in Peru, to 261 (Dominica, women) and 282 (Guyana, men). For non-HDL cholesterol, the lowest attributable rate was for women in Peru (21) and men in Guatemala (25), and the largest in men (158) and women (142) from Guyana. Interpretation: RRs for BMI from studies conducted in high-income countries may overestimate disease burden metrics in LAC; conversely, RRs for SBP, FPG and TC from LAC cohorts are similar to those estimated from cohorts in high-income countries. Funding: Wellcome Trust (214185/Z/18/Z).
| Item Type: | Article |
|---|---|
| Divisions: | Faculty of Science and Health > Health and Social Care, School of |
| SWORD Depositor: | Unnamed user with email elements@essex.ac.uk |
| Depositing User: | Unnamed user with email elements@essex.ac.uk |
| Date Deposited: | 16 Jan 2025 14:00 |
| Last Modified: | 16 Jan 2025 14:27 |
| URI: | http://repository.essex.ac.uk/id/eprint/36164 |
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