Amiri, Parisa and Jalali-Farahani, Sara and Karimi, Mehrdad and Taherian, Reza and Kazempour-Ardebili, Sara and Hosseini-Esfahani, Firoozeh and Mirmiran, Parvin and Azizi, Fereidoun (2017) Factors associated with pre-diabetes in Tehranian men and women: A structural equations modeling. PLOS ONE, 12 (12). e0188898. DOI https://doi.org/10.1371/journal.pone.0188898
Amiri, Parisa and Jalali-Farahani, Sara and Karimi, Mehrdad and Taherian, Reza and Kazempour-Ardebili, Sara and Hosseini-Esfahani, Firoozeh and Mirmiran, Parvin and Azizi, Fereidoun (2017) Factors associated with pre-diabetes in Tehranian men and women: A structural equations modeling. PLOS ONE, 12 (12). e0188898. DOI https://doi.org/10.1371/journal.pone.0188898
Amiri, Parisa and Jalali-Farahani, Sara and Karimi, Mehrdad and Taherian, Reza and Kazempour-Ardebili, Sara and Hosseini-Esfahani, Firoozeh and Mirmiran, Parvin and Azizi, Fereidoun (2017) Factors associated with pre-diabetes in Tehranian men and women: A structural equations modeling. PLOS ONE, 12 (12). e0188898. DOI https://doi.org/10.1371/journal.pone.0188898
Abstract
Objective: To examine associations of sex-specific related factors with pre-diabetes in Tehranian non-diabetic adults. Methods: This study has been conducted within the framework of the Tehran Lipid and Glucose Study (TLGS) between 2008–2010. A total of 5568 (55.4% female) non-diabetic adults, aged 20 years, selected from among participants of the TLGS, were recruited for the study. Data on socio-behavioral factors, family history of diabetes and cardio-metabolic risk factors were included in the hypothesized model to test their direct and indirect associations with pre-diabetes in men and women separately, using structural equation modeling. Results: Pre-diabetes was diagnosed in 23.6% of participants, with significantly higher prevalence in men compared to women (27.4% and 20.5%, respectively; p<0.001). Body mass index (BMI) and triglycerides (TG) in both sexes and hypertension and high density lipoprotein only in women, were directly associated with pre-diabetes (p<0.05). Poor diet in women was the only behavioral factor directly associated with pre-diabetes (p<0.05). Age in both sexes and education, only in women, were directly associated with pre-diabetes. In both genders, age, marital status, education, employment, poor diet and leisure time physical activity were indirectly associated with pre-diabetes through cardio-metabolic risk factors. Conclusions: The main modifiable factors directly associated with pre-diabetes were TG in women and BMI in men, which need to be prioritized in health policies for diabetes prevention programs in Tehranian adults. Future research should focus on the gender-specific determinants and underlying mechanisms for TG levels and BMI status among this population.
Item Type: | Article |
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Uncontrolled Keywords: | Humans; Prediabetic State; Models, Theoretical; Adult; Middle Aged; Iran; Female; Male |
Divisions: | Faculty of Science and Health > Health and Social Care, School of |
SWORD Depositor: | Unnamed user with email elements@essex.ac.uk |
Depositing User: | Unnamed user with email elements@essex.ac.uk |
Date Deposited: | 02 Jul 2025 13:34 |
Last Modified: | 02 Jul 2025 13:34 |
URI: | http://repository.essex.ac.uk/id/eprint/36266 |
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