Metodiev, Metodi and Alldridge, Louise (2008) Phosphoproteomics: A possible route to novel biomarkers of breast cancer. PROTEOMICS – Clinical Applications, 2 (2). pp. 181-194. DOI https://doi.org/10.1002/prca.200780011
Metodiev, Metodi and Alldridge, Louise (2008) Phosphoproteomics: A possible route to novel biomarkers of breast cancer. PROTEOMICS – Clinical Applications, 2 (2). pp. 181-194. DOI https://doi.org/10.1002/prca.200780011
Metodiev, Metodi and Alldridge, Louise (2008) Phosphoproteomics: A possible route to novel biomarkers of breast cancer. PROTEOMICS – Clinical Applications, 2 (2). pp. 181-194. DOI https://doi.org/10.1002/prca.200780011
Abstract
<jats:title>Abstract</jats:title><jats:p>Proteomics is rapidly transforming the way that cancer and other pathologies are investigated. The ability to identify hundreds of proteins and to compare their abundance in different clinical samples presents a unique opportunity for direct identification of novel disease markers. Furthermore, recent advances allow us to analyse and compare PTMs. This gives an additional dimension for defining a new class of protein biomarker based not only on abundance and expression but also on the occurrence of covalent modifications specific to a disease state or therapy response. Such modifications are often a consequence of the activation/inactivation of a particular disease related pathway. In this review we evaluate the available information on breast cancer related protein‐phosphorylation events, illustrating the rationale for investigating this PTM as a target for breast cancer research with eventual clinical relevance. We present a critical survey of the published experimental strategies to study protein phosphorylation on a system wide scale and highlight recent specific advances in breast cancer phosphoproteomics. Finally we discuss the feasibility of establishing novel biomarkers for breast cancer based on the detection of patterns of specific protein phosphorylation events.</jats:p>
Item Type: | Article |
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Uncontrolled Keywords: | biomarkers; breast cancer; phosphoproteomics |
Subjects: | R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) |
Divisions: | Faculty of Science and Health Faculty of Science and Health > Life Sciences, School of |
SWORD Depositor: | Unnamed user with email elements@essex.ac.uk |
Depositing User: | Unnamed user with email elements@essex.ac.uk |
Date Deposited: | 06 Oct 2011 13:25 |
Last Modified: | 30 Oct 2024 19:48 |
URI: | http://repository.essex.ac.uk/id/eprint/872 |