CES-486 A Map of Human Gene Expression

We have calculated the correlation between most human genes, using thousands of public Affymetrix HG-U133 +2 high-density oligonucleotide array (HDONAs). The correspondences show highly structured interactions between EBI Ensembl exons across a wide range of tissues and disease states taken from NCBI GEO. Eigen values are used to find and display the principle components of the gene expression mRNA data. The PCA analysis suggests almost all genes interact in a connected graph. There are thousands of strongly interacting genes but the whole network is sparse, with many genes not correlating strongly. So far, few power laws typical of “small world” networks and anticipated in gene regulatory networks have been found. The �300 million correlations are organised by gene/exon and are available via a web interface.