Malki, K and Keers, R and Tosto, MG and Lourdusamy, A and Carboni, L and Domenici, E and Uher, R and McGuffin, P and Schalkwyk, LC (2014) The endogenous and reactive depression subtypes revisited: integrative animal and human studies implicate multiple distinct molecular mechanisms underlying major depressive disorder. BMC Medicine, 12 (1). 73-. DOI https://doi.org/10.1186/1741-7015-12-73
Malki, K and Keers, R and Tosto, MG and Lourdusamy, A and Carboni, L and Domenici, E and Uher, R and McGuffin, P and Schalkwyk, LC (2014) The endogenous and reactive depression subtypes revisited: integrative animal and human studies implicate multiple distinct molecular mechanisms underlying major depressive disorder. BMC Medicine, 12 (1). 73-. DOI https://doi.org/10.1186/1741-7015-12-73
Malki, K and Keers, R and Tosto, MG and Lourdusamy, A and Carboni, L and Domenici, E and Uher, R and McGuffin, P and Schalkwyk, LC (2014) The endogenous and reactive depression subtypes revisited: integrative animal and human studies implicate multiple distinct molecular mechanisms underlying major depressive disorder. BMC Medicine, 12 (1). 73-. DOI https://doi.org/10.1186/1741-7015-12-73
Abstract
Traditional diagnoses of major depressive disorder (MDD) suggested that the presence or absence of stress prior to onset results in either 'reactive' or 'endogenous' subtypes of the disorder, respectively. Several lines of research suggest that the biological underpinnings of 'reactive' or 'endogenous' subtypes may also differ, resulting in differential response to treatment. We investigated this hypothesis by comparing the gene-expression profiles of three animal models of 'reactive' and 'endogenous' depression. We then translated these findings to clinical samples using a human post-mortem mRNA study.
Item Type: | Article |
---|---|
Uncontrolled Keywords: | Endogenous Depression; Reactive Depression; GENDEP; VAMP-2; DSM-IV; Stanley Brain Consortium; mRNA; Stress |
Subjects: | Q Science > QH Natural history > QH426 Genetics |
Divisions: | Faculty of Science and Health Faculty of Science and Health > Life Sciences, School of |
SWORD Depositor: | Unnamed user with email elements@essex.ac.uk |
Depositing User: | Unnamed user with email elements@essex.ac.uk |
Date Deposited: | 29 Oct 2014 10:16 |
Last Modified: | 07 Aug 2024 20:36 |
URI: | http://repository.essex.ac.uk/id/eprint/11064 |
Available files
Filename: 1741-7015-12-73.pdf
Licence: Creative Commons: Attribution 3.0