Punapart, M and Eltermaa, M and Oflijan, J and Sütt, S and Must, A and Kõks, S and Schalkwyk, LC and Fernandes, C and Vasar, E and Soomets, U and Terasmaa, A (2014) Effect of chronic valproic Acid treatment on hepatic gene expression profile in wfs1 knockout mouse. PPAR Research, 2014. pp. 1-11. DOI https://doi.org/10.1155/2014/349525
Punapart, M and Eltermaa, M and Oflijan, J and Sütt, S and Must, A and Kõks, S and Schalkwyk, LC and Fernandes, C and Vasar, E and Soomets, U and Terasmaa, A (2014) Effect of chronic valproic Acid treatment on hepatic gene expression profile in wfs1 knockout mouse. PPAR Research, 2014. pp. 1-11. DOI https://doi.org/10.1155/2014/349525
Punapart, M and Eltermaa, M and Oflijan, J and Sütt, S and Must, A and Kõks, S and Schalkwyk, LC and Fernandes, C and Vasar, E and Soomets, U and Terasmaa, A (2014) Effect of chronic valproic Acid treatment on hepatic gene expression profile in wfs1 knockout mouse. PPAR Research, 2014. pp. 1-11. DOI https://doi.org/10.1155/2014/349525
Abstract
Valproic acid (VPA) is a widely used anticonvulsant and mood-stabilizing drug whose use is often associated with drug-induced weight gain. Treatment with VPA has been shown to upregulate Wfs1 expression in vitro. Aim of the present study was to compare the effect of chronic VPA treatment in wild type (WT) and Wfs1 knockout (KO) mice on hepatic gene expression profile. Wild type, Wfs1 heterozygous, and homozygous mice were treated with VPA for three months (300?mg/kg i.p. daily) and gene expression profiles in liver were evaluated using Affymetrix Mouse GeneChip 1.0?ST array. We identified 42 genes affected by Wfs1 genotype, 10 genes regulated by VPA treatment, and 9 genes whose regulation by VPA was dependent on genotype. Among the genes that were regulated differentially by VPA depending on genotype was peroxisome proliferator-activated receptor delta (Ppard), whose expression was upregulated in response to VPA treatment in WT, but not in Wfs1 KO mice. Thus, regulation of Ppard by VPA is dependent on Wfs1 genotype.
Item Type: | Article |
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Subjects: | Q Science > QH Natural history > QH426 Genetics |
Divisions: | Faculty of Science and Health Faculty of Science and Health > Life Sciences, School of |
SWORD Depositor: | Unnamed user with email elements@essex.ac.uk |
Depositing User: | Unnamed user with email elements@essex.ac.uk |
Date Deposited: | 23 Oct 2014 12:33 |
Last Modified: | 07 Aug 2024 20:36 |
URI: | http://repository.essex.ac.uk/id/eprint/11097 |
Available files
Filename: 349525.pdf
Licence: Creative Commons: Attribution 3.0