Smith, RG and Fernandes, C and Kember, R and Schalkwyk, LC and Buxbaum, J and Reichenberg, A and Mill, J (2014) Transcriptomic changes in the frontal cortex associated with paternal age. Molecular Autism, 5 (1). creators-Schalkwyk=3ALeonard_C=3A=3A. DOI https://doi.org/10.1186/2040-2392-5-24
Smith, RG and Fernandes, C and Kember, R and Schalkwyk, LC and Buxbaum, J and Reichenberg, A and Mill, J (2014) Transcriptomic changes in the frontal cortex associated with paternal age. Molecular Autism, 5 (1). creators-Schalkwyk=3ALeonard_C=3A=3A. DOI https://doi.org/10.1186/2040-2392-5-24
Smith, RG and Fernandes, C and Kember, R and Schalkwyk, LC and Buxbaum, J and Reichenberg, A and Mill, J (2014) Transcriptomic changes in the frontal cortex associated with paternal age. Molecular Autism, 5 (1). creators-Schalkwyk=3ALeonard_C=3A=3A. DOI https://doi.org/10.1186/2040-2392-5-24
Abstract
Advanced paternal age is robustly associated with several human neuropsychiatric disorders, particularly autism. The precise mechanism(s) mediating the paternal age effect are not known, but they are thought to involve the accumulation of de novo (epi)genomic alterations. In this study we investigate differences in the frontal cortex transcriptome in a mouse model of advanced paternal age.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Autism; Advanced paternal age; Gene expression; Transcriptome; Inflammation; Immune response; Brain |
| Subjects: | Q Science > QH Natural history > QH426 Genetics |
| Divisions: | Faculty of Science and Health Faculty of Science and Health > Life Sciences, School of |
| SWORD Depositor: | Unnamed user with email elements@essex.ac.uk |
| Depositing User: | Unnamed user with email elements@essex.ac.uk |
| Date Deposited: | 29 Oct 2014 10:27 |
| Last Modified: | 15 Jan 2022 00:42 |
| URI: | http://repository.essex.ac.uk/id/eprint/11114 |
Available files
Filename: 2040-2392-5-24.pdf
Licence: Creative Commons: Attribution 3.0