Tabassum, Faiza and Kumari, Meena and Rumley, Ann and Power, Chris and Strachan, David P and Lowe, Gordon (2014) Lifecourse Social Position and D-Dimer; Findings from the 1958 British Birth Cohort. PLoS ONE, 9 (5). e93277-e93277. DOI https://doi.org/10.1371/journal.pone.0093277
Tabassum, Faiza and Kumari, Meena and Rumley, Ann and Power, Chris and Strachan, David P and Lowe, Gordon (2014) Lifecourse Social Position and D-Dimer; Findings from the 1958 British Birth Cohort. PLoS ONE, 9 (5). e93277-e93277. DOI https://doi.org/10.1371/journal.pone.0093277
Tabassum, Faiza and Kumari, Meena and Rumley, Ann and Power, Chris and Strachan, David P and Lowe, Gordon (2014) Lifecourse Social Position and D-Dimer; Findings from the 1958 British Birth Cohort. PLoS ONE, 9 (5). e93277-e93277. DOI https://doi.org/10.1371/journal.pone.0093277
Abstract
The aim is to examine the association of lifecourse socioeconomic position (SEP) on circulating levels of D-dimer. Data from the 1958 British birth cohort were used, social class was determined at three stages of respondents' life: at birth, at 23 and at 42 years. A cumulative indicator score of SEP (CIS) was calculated ranging from 0 (always in the highest social class) to 9 (always in the lowest social class). In men and women, associations were observed between CIS and D-dimer (P<0.05). Thus, the respondents in more disadvantaged social classes had elevated levels of D-dimer compared to respondents in less disadvantaged social class. In multivariate analyses, the association of disadvantaged social position with D-dimer was largely explained by fibrinogen, C-reactive protein and von Willebrand Factor in women, and additionally by smoking, alcohol consumption and physical activity in men. Socioeconomic circumstances across the lifecourse at various stages also contribute independently to raised levels of D-dimer in middle age in women only. Risk exposure related to SEP accumulates across life and contributes to raised levels of D-dimer. The association of haemostatic markers and social differences in health may be mediated by inflammatory and other markers. © 2014 Tabassum et al.
Item Type: | Article |
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Uncontrolled Keywords: | Humans; C-Reactive Protein; Fibrinogen; von Willebrand Factor; Fibrin Fibrinogen Degradation Products; Exercise; Risk Factors; Alcohol Drinking; Smoking; Sex Factors; Social Class; Middle Aged; Female; Male; Biomarkers |
Subjects: | H Social Sciences > H Social Sciences (General) R Medicine > R Medicine (General) |
Divisions: | Faculty of Social Sciences Faculty of Social Sciences > Institute for Social and Economic Research |
SWORD Depositor: | Unnamed user with email elements@essex.ac.uk |
Depositing User: | Unnamed user with email elements@essex.ac.uk |
Date Deposited: | 09 Jul 2015 14:23 |
Last Modified: | 30 Oct 2024 20:00 |
URI: | http://repository.essex.ac.uk/id/eprint/14276 |
Available files
Filename: journal.pone.0093277.pdf
Licence: Creative Commons: Attribution 3.0