Zabet, Nicolae Radu and Chu, Dominique F (2010) Computational limits to binary genes. Journal of The Royal Society Interface, 7 (47). pp. 945-954. DOI https://doi.org/10.1098/rsif.2009.0474
Zabet, Nicolae Radu and Chu, Dominique F (2010) Computational limits to binary genes. Journal of The Royal Society Interface, 7 (47). pp. 945-954. DOI https://doi.org/10.1098/rsif.2009.0474
Zabet, Nicolae Radu and Chu, Dominique F (2010) Computational limits to binary genes. Journal of The Royal Society Interface, 7 (47). pp. 945-954. DOI https://doi.org/10.1098/rsif.2009.0474
Abstract
<jats:p>We analyse the trade-off between the speed with which a gene can propagate information, the noise of its output and its metabolic cost. Our main finding is that for any given level of metabolic cost there is an optimal trade-off between noise and processing speed. Any system with a non-vanishing leak expression rate is suboptimal, i.e. it will exhibit higher noise and/or slower speed than leak-free systems with the same metabolic cost. We also show that there is an optimal Hill coefficient<jats:italic>h</jats:italic>which minimizes noise and metabolic cost at fixed speeds, and an optimal threshold<jats:italic>K</jats:italic>which minimizes noise.</jats:p>
Item Type: | Article |
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Uncontrolled Keywords: | noise; speed; metabolic cost; trade-off |
Subjects: | Q Science > QC Physics Q Science > QH Natural history > QH426 Genetics |
Divisions: | Faculty of Science and Health Faculty of Science and Health > Life Sciences, School of |
SWORD Depositor: | Unnamed user with email elements@essex.ac.uk |
Depositing User: | Unnamed user with email elements@essex.ac.uk |
Date Deposited: | 17 Dec 2015 12:42 |
Last Modified: | 07 Aug 2024 20:37 |
URI: | http://repository.essex.ac.uk/id/eprint/15118 |