Linneberg, Allan and Jacobsen, Rikke K and Skaaby, Tea and Taylor, Amy E and Fluharty, Meg E and Jeppesen, Jørgen L and Bjorngaard, Johan H and Åsvold, Bjørn O and Gabrielsen, Maiken E and Campbell, Archie and Marioni, Riccardo E and Kumari, Meena and Marques-Vidal, Pedro and Kaakinen, Marika and Cavadino, Alana and Postmus, Iris and Ahluwalia, Tarunveer S and Wannamethee, S Goya and Lahti, Jari and Räikkönen, Katri and Palotie, Aarno and Wong, Andrew and Dalgård, Christine and Ford, Ian and Ben-Shlomo, Yoav and Christiansen, Lene and Kyvik, Kirsten O and Kuh, Diana and Eriksson, Johan G and Whincup, Peter H and Mbarek, Hamdi and de Geus, Eco JC and Vink, Jacqueline M and Boomsma, Dorret I and Smith, George Davey and Lawlor, Debbie A and Kisialiou, Aliaksei and McConnachie, Alex and Padmanabhan, Sandosh and Jukema, J Wouter and Power, Chris and Hyppönen, Elina and Preisig, Martin and Waeber, Gerard and Vollenweider, Peter and Korhonen, Tellervo and Laatikainen, Tiina and Salomaa, Veikko and Kaprio, Jaakko and Kivimaki, Mika and Smith, Blair H and Hayward, Caroline and Sørensen, Thorkild IA and Thuesen, Betina H and Sattar, Naveed and Morris, Richard W and Romundstad, Pål R and Munafò, Marcus R and Jarvelin, Marjo-Riitta and Husemoen, Lise Lotte N (2015) Effect of Smoking on Blood Pressure and Resting Heart Rate. Circulation: Cardiovascular Genetics, 8 (6). pp. 832-841. DOI https://doi.org/10.1161/circgenetics.115.001225
Linneberg, Allan and Jacobsen, Rikke K and Skaaby, Tea and Taylor, Amy E and Fluharty, Meg E and Jeppesen, Jørgen L and Bjorngaard, Johan H and Åsvold, Bjørn O and Gabrielsen, Maiken E and Campbell, Archie and Marioni, Riccardo E and Kumari, Meena and Marques-Vidal, Pedro and Kaakinen, Marika and Cavadino, Alana and Postmus, Iris and Ahluwalia, Tarunveer S and Wannamethee, S Goya and Lahti, Jari and Räikkönen, Katri and Palotie, Aarno and Wong, Andrew and Dalgård, Christine and Ford, Ian and Ben-Shlomo, Yoav and Christiansen, Lene and Kyvik, Kirsten O and Kuh, Diana and Eriksson, Johan G and Whincup, Peter H and Mbarek, Hamdi and de Geus, Eco JC and Vink, Jacqueline M and Boomsma, Dorret I and Smith, George Davey and Lawlor, Debbie A and Kisialiou, Aliaksei and McConnachie, Alex and Padmanabhan, Sandosh and Jukema, J Wouter and Power, Chris and Hyppönen, Elina and Preisig, Martin and Waeber, Gerard and Vollenweider, Peter and Korhonen, Tellervo and Laatikainen, Tiina and Salomaa, Veikko and Kaprio, Jaakko and Kivimaki, Mika and Smith, Blair H and Hayward, Caroline and Sørensen, Thorkild IA and Thuesen, Betina H and Sattar, Naveed and Morris, Richard W and Romundstad, Pål R and Munafò, Marcus R and Jarvelin, Marjo-Riitta and Husemoen, Lise Lotte N (2015) Effect of Smoking on Blood Pressure and Resting Heart Rate. Circulation: Cardiovascular Genetics, 8 (6). pp. 832-841. DOI https://doi.org/10.1161/circgenetics.115.001225
Linneberg, Allan and Jacobsen, Rikke K and Skaaby, Tea and Taylor, Amy E and Fluharty, Meg E and Jeppesen, Jørgen L and Bjorngaard, Johan H and Åsvold, Bjørn O and Gabrielsen, Maiken E and Campbell, Archie and Marioni, Riccardo E and Kumari, Meena and Marques-Vidal, Pedro and Kaakinen, Marika and Cavadino, Alana and Postmus, Iris and Ahluwalia, Tarunveer S and Wannamethee, S Goya and Lahti, Jari and Räikkönen, Katri and Palotie, Aarno and Wong, Andrew and Dalgård, Christine and Ford, Ian and Ben-Shlomo, Yoav and Christiansen, Lene and Kyvik, Kirsten O and Kuh, Diana and Eriksson, Johan G and Whincup, Peter H and Mbarek, Hamdi and de Geus, Eco JC and Vink, Jacqueline M and Boomsma, Dorret I and Smith, George Davey and Lawlor, Debbie A and Kisialiou, Aliaksei and McConnachie, Alex and Padmanabhan, Sandosh and Jukema, J Wouter and Power, Chris and Hyppönen, Elina and Preisig, Martin and Waeber, Gerard and Vollenweider, Peter and Korhonen, Tellervo and Laatikainen, Tiina and Salomaa, Veikko and Kaprio, Jaakko and Kivimaki, Mika and Smith, Blair H and Hayward, Caroline and Sørensen, Thorkild IA and Thuesen, Betina H and Sattar, Naveed and Morris, Richard W and Romundstad, Pål R and Munafò, Marcus R and Jarvelin, Marjo-Riitta and Husemoen, Lise Lotte N (2015) Effect of Smoking on Blood Pressure and Resting Heart Rate. Circulation: Cardiovascular Genetics, 8 (6). pp. 832-841. DOI https://doi.org/10.1161/circgenetics.115.001225
Abstract
<jats:sec> <jats:title>Background—</jats:title> <jats:p>Smoking is an important cardiovascular disease risk factor, but the mechanisms linking smoking to blood pressure are poorly understood.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods and Results—</jats:title> <jats:p>Data on 141 317 participants (62 666 never, 40 669 former, 37 982 current smokers) from 23 population-based studies were included in observational and Mendelian randomization meta-analyses of the associations of smoking status and smoking heaviness with systolic and diastolic blood pressure, hypertension, and resting heart rate. For the Mendelian randomization analyses, a genetic variant rs16969968/rs1051730 was used as a proxy for smoking heaviness in current smokers. In observational analyses, current as compared with never smoking was associated with lower systolic blood pressure and diastolic blood pressure and lower hypertension risk, but with higher resting heart rate. In observational analyses among current smokers, 1 cigarette/day higher level of smoking heaviness was associated with higher (0.21 bpm; 95% confidence interval 0.19; 0.24) resting heart rate and slightly higher diastolic blood pressure (0.05 mm Hg; 95% confidence interval 0.02; 0.08) and systolic blood pressure (0.08 mm Hg; 95% confidence interval 0.03; 0.13). However, in Mendelian randomization analyses among current smokers, although each smoking increasing allele of rs16969968/rs1051730 was associated with higher resting heart rate (0.36 bpm/allele; 95% confidence interval 0.18; 0.54), there was no strong association with diastolic blood pressure, systolic blood pressure, or hypertension. This would suggest a 7 bpm higher heart rate in those who smoke 20 cigarettes/day.</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions—</jats:title> <jats:p>This Mendelian randomization meta-analysis supports a causal association of smoking heaviness with higher level of resting heart rate, but not with blood pressure. These findings suggest that part of the cardiovascular risk of smoking may operate through increasing resting heart rate.</jats:p> </jats:sec>
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | blood pressure; heart rate; hypertension; Mendelian randomization; smoking |
| Subjects: | H Social Sciences > H Social Sciences (General) R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine |
| Divisions: | Faculty of Social Sciences Faculty of Social Sciences > Institute for Social and Economic Research |
| SWORD Depositor: | Unnamed user with email elements@essex.ac.uk |
| Depositing User: | Unnamed user with email elements@essex.ac.uk |
| Date Deposited: | 12 Feb 2016 12:09 |
| Last Modified: | 30 Oct 2024 20:02 |
| URI: | http://repository.essex.ac.uk/id/eprint/15795 |