Malki, Karim and Du Rietz, Ebba and Crusio, Wim E and Pain, Oliver and Paya‐Cano, Jose and Karadaghi, Rezhaw L and Sluyter, Frans and de Boer, Sietse F and Sandnabba, Kenneth and Schalkwyk, Leonard C and Asherson, Philip and Tosto, Maria Grazia (2016) Transcriptome analysis of genes and gene networks involved in aggressive behavior in mouse and zebrafish. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 171 (6). pp. 827-838. DOI https://doi.org/10.1002/ajmg.b.32451
Malki, Karim and Du Rietz, Ebba and Crusio, Wim E and Pain, Oliver and Paya‐Cano, Jose and Karadaghi, Rezhaw L and Sluyter, Frans and de Boer, Sietse F and Sandnabba, Kenneth and Schalkwyk, Leonard C and Asherson, Philip and Tosto, Maria Grazia (2016) Transcriptome analysis of genes and gene networks involved in aggressive behavior in mouse and zebrafish. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 171 (6). pp. 827-838. DOI https://doi.org/10.1002/ajmg.b.32451
Malki, Karim and Du Rietz, Ebba and Crusio, Wim E and Pain, Oliver and Paya‐Cano, Jose and Karadaghi, Rezhaw L and Sluyter, Frans and de Boer, Sietse F and Sandnabba, Kenneth and Schalkwyk, Leonard C and Asherson, Philip and Tosto, Maria Grazia (2016) Transcriptome analysis of genes and gene networks involved in aggressive behavior in mouse and zebrafish. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 171 (6). pp. 827-838. DOI https://doi.org/10.1002/ajmg.b.32451
Abstract
<jats:sec><jats:label /><jats:p>Despite moderate heritability estimates, the molecular architecture of aggressive behavior remains poorly characterized. This study compared gene expression profiles from a genetic mouse model of aggression with zebrafish, an animal model traditionally used to study aggression. A meta‐analytic, cross‐species approach was used to identify genomic variants associated with aggressive behavior. The Rankprod algorithm was used to evaluated mRNA differences from prefrontal cortex tissues of three sets of mouse lines (N = 18) selectively bred for low and high aggressive behavior (SAL/LAL, TA/TNA, and NC900/NC100). The same approach was used to evaluate mRNA differences in zebrafish (N = 12) exposed to aggressive or non‐aggressive social encounters. Results were compared to uncover genes consistently implicated in aggression across both studies. Seventy‐six genes were differentially expressed (PFP < 0.05) in aggressive compared to non‐aggressive mice. Seventy genes were differentially expressed in zebrafish exposed to a fight encounter compared to isolated zebrafish. Seven genes (<jats:italic>Fos</jats:italic>, <jats:italic>Dusp1</jats:italic>, <jats:italic>Hdac4</jats:italic>, <jats:italic>Ier2</jats:italic>, <jats:italic>Bdnf</jats:italic>, <jats:italic>Btg2</jats:italic>, and <jats:italic>Nr4a1</jats:italic>) were differentially expressed across both species 5 of which belonging to a gene‐network centred on the <jats:italic>c‐Fos</jats:italic> gene hub. Network analysis revealed an association with the MAPK signaling cascade. In human studies <jats:italic>HDAC4</jats:italic> haploinsufficiency is a key genetic mechanism associated with brachydactyly mental retardation syndrome (BDMR), which is associated with aggressive behaviors. Moreover, the HDAC4 receptor is a drug target for valproic acid, which is being employed as an effective pharmacological treatment for aggressive behavior in geriatric, psychiatric, and brain‐injury patients. © 2016 Wiley Periodicals, Inc.</jats:p></jats:sec>
Item Type: | Article |
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Uncontrolled Keywords: | SAL; LAL; TA; TNA; NC900; NC100; aggression; RankProd |
Subjects: | Q Science > QH Natural history > QH426 Genetics |
Divisions: | Faculty of Science and Health Faculty of Science and Health > Life Sciences, School of |
SWORD Depositor: | Unnamed user with email elements@essex.ac.uk |
Depositing User: | Unnamed user with email elements@essex.ac.uk |
Date Deposited: | 09 May 2016 11:47 |
Last Modified: | 07 Aug 2024 20:34 |
URI: | http://repository.essex.ac.uk/id/eprint/16479 |
Available files
Filename: Zebrafish2.pdf