Leusink, Maarten and Maitland-van der Zee, Anke H and Ding, Bo and Drenos, Fotios and van Iperen, Erik PA and Warren, Helen R and Caulfield, Mark J and Cupples, L Adrienne and Cushman, Mary and Hingorani, Aroon D and Hoogeveen, Ron C and Hovingh, G Kees and Kumari, Meena and Lange, Leslie A and Munroe, Patricia B and Nyberg, Fredrik and Schreiner, Pamela J and Sivapalaratnam, Suthesh and de Bakker, Paul IW and de Boer, Anthonius and Keating, Brendan J and Asselbergs, Folkert W and Onland-Moret, N Charlotte (2016) A genetic risk score is associated with statin-induced low-density lipoprotein cholesterol lowering. Pharmacogenomics, 17 (6). pp. 583-591. DOI https://doi.org/10.2217/pgs.16.8
Leusink, Maarten and Maitland-van der Zee, Anke H and Ding, Bo and Drenos, Fotios and van Iperen, Erik PA and Warren, Helen R and Caulfield, Mark J and Cupples, L Adrienne and Cushman, Mary and Hingorani, Aroon D and Hoogeveen, Ron C and Hovingh, G Kees and Kumari, Meena and Lange, Leslie A and Munroe, Patricia B and Nyberg, Fredrik and Schreiner, Pamela J and Sivapalaratnam, Suthesh and de Bakker, Paul IW and de Boer, Anthonius and Keating, Brendan J and Asselbergs, Folkert W and Onland-Moret, N Charlotte (2016) A genetic risk score is associated with statin-induced low-density lipoprotein cholesterol lowering. Pharmacogenomics, 17 (6). pp. 583-591. DOI https://doi.org/10.2217/pgs.16.8
Leusink, Maarten and Maitland-van der Zee, Anke H and Ding, Bo and Drenos, Fotios and van Iperen, Erik PA and Warren, Helen R and Caulfield, Mark J and Cupples, L Adrienne and Cushman, Mary and Hingorani, Aroon D and Hoogeveen, Ron C and Hovingh, G Kees and Kumari, Meena and Lange, Leslie A and Munroe, Patricia B and Nyberg, Fredrik and Schreiner, Pamela J and Sivapalaratnam, Suthesh and de Bakker, Paul IW and de Boer, Anthonius and Keating, Brendan J and Asselbergs, Folkert W and Onland-Moret, N Charlotte (2016) A genetic risk score is associated with statin-induced low-density lipoprotein cholesterol lowering. Pharmacogenomics, 17 (6). pp. 583-591. DOI https://doi.org/10.2217/pgs.16.8
Abstract
Aim: To find new genetic loci associated with statin response, and to investigate the association of a genetic risk score (GRS) with this outcome. Patients & Methods: In a discovery meta-analysis (five studies, 1991 individuals), we investigated the effects of approximately 50000 single nucleotide polymorphisms on statin response, following up associations with p < 1 × 10(-4) (three independent studies, 5314 individuals). We further assessed the effect of a GRS based on SNPs in ABCG2, LPA and APOE. Results: No new SNPs were found associated with statin response. The GRS was associated with reduced statin response: 0.0394 mmol/l per allele (95% CI: 0.0171-0.0617, p = 5.37 × 10(-4)). Conclusion: The GRS was associated with statin response, but the small effect size (˜2% of the average low-density lipoprotein cholesterol reduction) limits applicability.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | pharmacogenetics cholesterol; risk score; statin therapy |
| Subjects: | H Social Sciences > H Social Sciences (General) R Medicine > R Medicine (General) |
| Divisions: | Faculty of Social Sciences Faculty of Social Sciences > Institute for Social and Economic Research |
| SWORD Depositor: | Unnamed user with email elements@essex.ac.uk |
| Depositing User: | Unnamed user with email elements@essex.ac.uk |
| Date Deposited: | 23 Feb 2018 12:59 |
| Last Modified: | 30 Oct 2024 16:09 |
| URI: | http://repository.essex.ac.uk/id/eprint/21495 |