Ehret, Georg B and Ferreira, Teresa and Chasman, Daniel I and Jackson, Anne U and Schmidt, Ellen M and Johnson, Toby and Thorleifsson, Gudmar and Luan, Jian'an and Donnelly, Louise A and Kanoni, Stavroula and Petersen, Ann-Kristin and Pihur, Vasyl and Strawbridge, Rona J and Shungin, Dmitry and Hughes, Maria F and Meirelles, Osorio and Kaakinen, Marika and Bouatia-Naji, Nabila and Kristiansson, Kati and Shah, Sonia and Kleber, Marcus E and Guo, Xiuqing and Lyytikäinen, Leo-Pekka and Fava, Cristiano and Eriksson, Niclas and Nolte, Ilja M and Magnusson, Patrik K and Salfati, Elias L and Rallidis, Loukianos S and Theusch, Elizabeth and Smith, Andrew JP and Folkersen, Lasse and Witkowska, Kate and Pers, Tune H and Joehanes, Roby and Kim, Stuart K and Lataniotis, Lazaros and Jansen, Rick and Johnson, Andrew D and Warren, Helen and Kim, Young Jin and Zhao, Wei and Wu, Ying and Tayo, Bamidele O and Bochud, Murielle and Absher, Devin and Adair, Linda S and Amin, Najaf and Arking, Dan E and Axelsson, Tomas and Baldassarre, Damiano and Balkau, Beverley and Bandinelli, Stefania and Barnes, Michael R and Barroso, Inês and Bevan, Stephen and Bis, Joshua C and Bjornsdottir, Gyda and Boehnke, Michael and Boerwinkle, Eric and Bonnycastle, Lori L and Boomsma, Dorret I and Bornstein, Stefan R and Brown, Morris J and Burnier, Michel and Cabrera, Claudia P and Chambers, John C and Chang, I-Shou and Cheng, Ching-Yu and Chines, Peter S and Chung, Ren-Hua and Collins, Francis S and Connell, John M and Döring, Angela and Dallongeville, Jean and Danesh, John and de Faire, Ulf and Delgado, Graciela and Dominiczak, Anna F and Doney, Alex SF and Drenos, Fotios and Edkins, Sarah and Eicher, John D and Elosua, Roberto and Enroth, Stefan and Erdmann, Jeanette and Eriksson, Per and Esko, Tonu and Evangelou, Evangelos and Evans, Alun and Fall, Tove and Farrall, Martin and Felix, Janine F and Ferrières, Jean and Ferrucci, Luigi and Fornage, Myriam and Forrester, Terrence and Franceschini, Nora and Franco, Oscar H and Franco-Cereceda, Anders and Fraser, Ross M and Ganesh, Santhi K and Gao, He and Gertow, Karl and Gianfagna, Francesco and Gigante, Bruna and Giulianini, Franco and Goel, Anuj and Goodall, Alison H and Goodarzi, Mark O and Gorski, Mathias and Gräßler, Jürgen and Groves, Christopher J and Gudnason, Vilmundur and Gyllensten, Ulf and Hallmans, Göran and Hartikainen, Anna-Liisa and Hassinen, Maija and Havulinna, Aki S and Hayward, Caroline and Hercberg, Serge and Herzig, Karl-Heinz and Hicks, Andrew A and Hingorani, Aroon D and Hirschhorn, Joel N and Hofman, Albert and Holmen, Jostein and Holmen, Oddgeir Lingaas and Hottenga, Jouke-Jan and Howard, Phil and Hsiung, Chao A and Hunt, Steven C and Ikram, M Arfan and Illig, Thomas and Iribarren, Carlos and Jensen, Richard A and Kähönen, Mika and Kang, Hyun Min and Kathiresan, Sekar and Keating, Brendan J and Khaw, Kay-Tee and Kim, Yun Kyoung and Kim, Eric and Kivimaki, Mika and Klopp, Norman and Kolovou, Genovefa and Komulainen, Pirjo and Kooner, Jaspal S and Kosova, Gulum and Krauss, Ronald M and Kuh, Diana and Kutalik, Zoltan and Kuusisto, Johanna and Kvaløy, Kirsti and Lakka, Timo A and Lee, Nanette R and Lee, I-Te and Lee, Wen-Jane and Levy, Daniel and Li, Xiaohui and Liang, Kae-Woei and Lin, Honghuang and Lin, Li and Lindström, Jaana and Lobbens, Stéphane and Männistö, Satu and Müller, Gabriele and Müller-Nurasyid, Martina and Mach, François and Markus, Hugh S and Marouli, Eirini and McCarthy, Mark I and McKenzie, Colin A and Meneton, Pierre and Menni, Cristina and Metspalu, Andres and Mijatovic, Vladan and Moilanen, Leena and Montasser, May E and Morris, Andrew D and Morrison, Alanna C and Mulas, Antonella and Nagaraja, Ramaiah and Narisu, Narisu and Nikus, Kjell and O'Donnell, Christopher J and O'Reilly, Paul F and Ong, Ken K and Paccaud, Fred and Palmer, Cameron D and Parsa, Afshin and Pedersen, Nancy L and Penninx, Brenda W and Perola, Markus and Peters, Annette and Poulter, Neil and Pramstaller, Peter P and Psaty, Bruce M and Quertermous, Thomas and Rao, Dabeeru C and Rasheed, Asif and Rayner, N William and Renström, Frida and Rettig, Rainer and Rice, Kenneth M and Roberts, Robert and Rose, Lynda M and Rossouw, Jacques and Samani, Nilesh J and Sanna, Serena and Saramies, Jouko and Schunkert, Heribert and Sebert, Sylvain and Sheu, Wayne H-H and Shin, Young-Ah and Sim, Xueling and Smit, Johannes H and Smith, Albert V and Sosa, Maria X and Spector, Tim D and Stančáková, Alena and Stanton, Alice V and Stirrups, Kathleen E and Stringham, Heather M and Sundstrom, Johan and Swift, Amy J and Syvänen, Ann-Christine and Tai, E-Shyong and Tanaka, Toshiko and Tarasov, Kirill V and Teumer, Alexander and Thorsteinsdottir, Unnur and Tobin, Martin D and Tremoli, Elena and Uitterlinden, Andre G and Uusitupa, Matti and Vaez, Ahmad and Vaidya, Dhananjay and van Duijn, Cornelia M and van Iperen, Erik PA and Vasan, Ramachandran S and Verwoert, Germaine C and Virtamo, Jarmo and Vitart, Veronique and Voight, Benjamin F and Vollenweider, Peter and Wagner, Aline and Wain, Louise V and Wareham, Nicholas J and Watkins, Hugh and Weder, Alan B and Westra, Harm-Jan and Wilks, Rainford and Wilsgaard, Tom and Wilson, James F and Wong, Tien Y and Yang, Tsun-Po and Yao, Jie and Yengo, Loic and Zhang, Weihua and Zhao, Jing Hua and Zhu, Xiaofeng and Bovet, Pascal and Cooper, Richard S and Mohlke, Karen L and Saleheen, Danish and Lee, Jong-Young and Elliott, Paul and Gierman, Hinco J and Willer, Cristen J and Franke, Lude and Hovingh, G Kees and Taylor, Kent D and Dedoussis, George and Sever, Peter and Wong, Andrew and Lind, Lars and Assimes, Themistocles L and Njølstad, Inger and Schwarz, Peter EH and Langenberg, Claudia and Snieder, Harold and Caulfield, Mark J and Melander, Olle and Laakso, Markku and Saltevo, Juha and Rauramaa, Rainer and Tuomilehto, Jaakko and Ingelsson, Erik and Lehtimäki, Terho and Hveem, Kristian and Palmas, Walter and März, Winfried and Kumari, Meena and Salomaa, Veikko and Chen, Yii-Der I and Rotter, Jerome I and Froguel, Philippe and Jarvelin, Marjo-Riitta and Lakatta, Edward G and Kuulasmaa, Kari and Franks, Paul W and Hamsten, Anders and Wichmann, H-Erich and Palmer, Colin NA and Stefansson, Kari and Ridker, Paul M and Loos, Ruth JF and Chakravarti, Aravinda and Deloukas, Panos and Morris, Andrew P and Newton-Cheh, Christopher and Munroe, Patricia B (2016) The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals. Nature Genetics, 48 (10). pp. 1171-1184. DOI https://doi.org/10.1038/ng.3667
Ehret, Georg B and Ferreira, Teresa and Chasman, Daniel I and Jackson, Anne U and Schmidt, Ellen M and Johnson, Toby and Thorleifsson, Gudmar and Luan, Jian'an and Donnelly, Louise A and Kanoni, Stavroula and Petersen, Ann-Kristin and Pihur, Vasyl and Strawbridge, Rona J and Shungin, Dmitry and Hughes, Maria F and Meirelles, Osorio and Kaakinen, Marika and Bouatia-Naji, Nabila and Kristiansson, Kati and Shah, Sonia and Kleber, Marcus E and Guo, Xiuqing and Lyytikäinen, Leo-Pekka and Fava, Cristiano and Eriksson, Niclas and Nolte, Ilja M and Magnusson, Patrik K and Salfati, Elias L and Rallidis, Loukianos S and Theusch, Elizabeth and Smith, Andrew JP and Folkersen, Lasse and Witkowska, Kate and Pers, Tune H and Joehanes, Roby and Kim, Stuart K and Lataniotis, Lazaros and Jansen, Rick and Johnson, Andrew D and Warren, Helen and Kim, Young Jin and Zhao, Wei and Wu, Ying and Tayo, Bamidele O and Bochud, Murielle and Absher, Devin and Adair, Linda S and Amin, Najaf and Arking, Dan E and Axelsson, Tomas and Baldassarre, Damiano and Balkau, Beverley and Bandinelli, Stefania and Barnes, Michael R and Barroso, Inês and Bevan, Stephen and Bis, Joshua C and Bjornsdottir, Gyda and Boehnke, Michael and Boerwinkle, Eric and Bonnycastle, Lori L and Boomsma, Dorret I and Bornstein, Stefan R and Brown, Morris J and Burnier, Michel and Cabrera, Claudia P and Chambers, John C and Chang, I-Shou and Cheng, Ching-Yu and Chines, Peter S and Chung, Ren-Hua and Collins, Francis S and Connell, John M and Döring, Angela and Dallongeville, Jean and Danesh, John and de Faire, Ulf and Delgado, Graciela and Dominiczak, Anna F and Doney, Alex SF and Drenos, Fotios and Edkins, Sarah and Eicher, John D and Elosua, Roberto and Enroth, Stefan and Erdmann, Jeanette and Eriksson, Per and Esko, Tonu and Evangelou, Evangelos and Evans, Alun and Fall, Tove and Farrall, Martin and Felix, Janine F and Ferrières, Jean and Ferrucci, Luigi and Fornage, Myriam and Forrester, Terrence and Franceschini, Nora and Franco, Oscar H and Franco-Cereceda, Anders and Fraser, Ross M and Ganesh, Santhi K and Gao, He and Gertow, Karl and Gianfagna, Francesco and Gigante, Bruna and Giulianini, Franco and Goel, Anuj and Goodall, Alison H and Goodarzi, Mark O and Gorski, Mathias and Gräßler, Jürgen and Groves, Christopher J and Gudnason, Vilmundur and Gyllensten, Ulf and Hallmans, Göran and Hartikainen, Anna-Liisa and Hassinen, Maija and Havulinna, Aki S and Hayward, Caroline and Hercberg, Serge and Herzig, Karl-Heinz and Hicks, Andrew A and Hingorani, Aroon D and Hirschhorn, Joel N and Hofman, Albert and Holmen, Jostein and Holmen, Oddgeir Lingaas and Hottenga, Jouke-Jan and Howard, Phil and Hsiung, Chao A and Hunt, Steven C and Ikram, M Arfan and Illig, Thomas and Iribarren, Carlos and Jensen, Richard A and Kähönen, Mika and Kang, Hyun Min and Kathiresan, Sekar and Keating, Brendan J and Khaw, Kay-Tee and Kim, Yun Kyoung and Kim, Eric and Kivimaki, Mika and Klopp, Norman and Kolovou, Genovefa and Komulainen, Pirjo and Kooner, Jaspal S and Kosova, Gulum and Krauss, Ronald M and Kuh, Diana and Kutalik, Zoltan and Kuusisto, Johanna and Kvaløy, Kirsti and Lakka, Timo A and Lee, Nanette R and Lee, I-Te and Lee, Wen-Jane and Levy, Daniel and Li, Xiaohui and Liang, Kae-Woei and Lin, Honghuang and Lin, Li and Lindström, Jaana and Lobbens, Stéphane and Männistö, Satu and Müller, Gabriele and Müller-Nurasyid, Martina and Mach, François and Markus, Hugh S and Marouli, Eirini and McCarthy, Mark I and McKenzie, Colin A and Meneton, Pierre and Menni, Cristina and Metspalu, Andres and Mijatovic, Vladan and Moilanen, Leena and Montasser, May E and Morris, Andrew D and Morrison, Alanna C and Mulas, Antonella and Nagaraja, Ramaiah and Narisu, Narisu and Nikus, Kjell and O'Donnell, Christopher J and O'Reilly, Paul F and Ong, Ken K and Paccaud, Fred and Palmer, Cameron D and Parsa, Afshin and Pedersen, Nancy L and Penninx, Brenda W and Perola, Markus and Peters, Annette and Poulter, Neil and Pramstaller, Peter P and Psaty, Bruce M and Quertermous, Thomas and Rao, Dabeeru C and Rasheed, Asif and Rayner, N William and Renström, Frida and Rettig, Rainer and Rice, Kenneth M and Roberts, Robert and Rose, Lynda M and Rossouw, Jacques and Samani, Nilesh J and Sanna, Serena and Saramies, Jouko and Schunkert, Heribert and Sebert, Sylvain and Sheu, Wayne H-H and Shin, Young-Ah and Sim, Xueling and Smit, Johannes H and Smith, Albert V and Sosa, Maria X and Spector, Tim D and Stančáková, Alena and Stanton, Alice V and Stirrups, Kathleen E and Stringham, Heather M and Sundstrom, Johan and Swift, Amy J and Syvänen, Ann-Christine and Tai, E-Shyong and Tanaka, Toshiko and Tarasov, Kirill V and Teumer, Alexander and Thorsteinsdottir, Unnur and Tobin, Martin D and Tremoli, Elena and Uitterlinden, Andre G and Uusitupa, Matti and Vaez, Ahmad and Vaidya, Dhananjay and van Duijn, Cornelia M and van Iperen, Erik PA and Vasan, Ramachandran S and Verwoert, Germaine C and Virtamo, Jarmo and Vitart, Veronique and Voight, Benjamin F and Vollenweider, Peter and Wagner, Aline and Wain, Louise V and Wareham, Nicholas J and Watkins, Hugh and Weder, Alan B and Westra, Harm-Jan and Wilks, Rainford and Wilsgaard, Tom and Wilson, James F and Wong, Tien Y and Yang, Tsun-Po and Yao, Jie and Yengo, Loic and Zhang, Weihua and Zhao, Jing Hua and Zhu, Xiaofeng and Bovet, Pascal and Cooper, Richard S and Mohlke, Karen L and Saleheen, Danish and Lee, Jong-Young and Elliott, Paul and Gierman, Hinco J and Willer, Cristen J and Franke, Lude and Hovingh, G Kees and Taylor, Kent D and Dedoussis, George and Sever, Peter and Wong, Andrew and Lind, Lars and Assimes, Themistocles L and Njølstad, Inger and Schwarz, Peter EH and Langenberg, Claudia and Snieder, Harold and Caulfield, Mark J and Melander, Olle and Laakso, Markku and Saltevo, Juha and Rauramaa, Rainer and Tuomilehto, Jaakko and Ingelsson, Erik and Lehtimäki, Terho and Hveem, Kristian and Palmas, Walter and März, Winfried and Kumari, Meena and Salomaa, Veikko and Chen, Yii-Der I and Rotter, Jerome I and Froguel, Philippe and Jarvelin, Marjo-Riitta and Lakatta, Edward G and Kuulasmaa, Kari and Franks, Paul W and Hamsten, Anders and Wichmann, H-Erich and Palmer, Colin NA and Stefansson, Kari and Ridker, Paul M and Loos, Ruth JF and Chakravarti, Aravinda and Deloukas, Panos and Morris, Andrew P and Newton-Cheh, Christopher and Munroe, Patricia B (2016) The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals. Nature Genetics, 48 (10). pp. 1171-1184. DOI https://doi.org/10.1038/ng.3667
Ehret, Georg B and Ferreira, Teresa and Chasman, Daniel I and Jackson, Anne U and Schmidt, Ellen M and Johnson, Toby and Thorleifsson, Gudmar and Luan, Jian'an and Donnelly, Louise A and Kanoni, Stavroula and Petersen, Ann-Kristin and Pihur, Vasyl and Strawbridge, Rona J and Shungin, Dmitry and Hughes, Maria F and Meirelles, Osorio and Kaakinen, Marika and Bouatia-Naji, Nabila and Kristiansson, Kati and Shah, Sonia and Kleber, Marcus E and Guo, Xiuqing and Lyytikäinen, Leo-Pekka and Fava, Cristiano and Eriksson, Niclas and Nolte, Ilja M and Magnusson, Patrik K and Salfati, Elias L and Rallidis, Loukianos S and Theusch, Elizabeth and Smith, Andrew JP and Folkersen, Lasse and Witkowska, Kate and Pers, Tune H and Joehanes, Roby and Kim, Stuart K and Lataniotis, Lazaros and Jansen, Rick and Johnson, Andrew D and Warren, Helen and Kim, Young Jin and Zhao, Wei and Wu, Ying and Tayo, Bamidele O and Bochud, Murielle and Absher, Devin and Adair, Linda S and Amin, Najaf and Arking, Dan E and Axelsson, Tomas and Baldassarre, Damiano and Balkau, Beverley and Bandinelli, Stefania and Barnes, Michael R and Barroso, Inês and Bevan, Stephen and Bis, Joshua C and Bjornsdottir, Gyda and Boehnke, Michael and Boerwinkle, Eric and Bonnycastle, Lori L and Boomsma, Dorret I and Bornstein, Stefan R and Brown, Morris J and Burnier, Michel and Cabrera, Claudia P and Chambers, John C and Chang, I-Shou and Cheng, Ching-Yu and Chines, Peter S and Chung, Ren-Hua and Collins, Francis S and Connell, John M and Döring, Angela and Dallongeville, Jean and Danesh, John and de Faire, Ulf and Delgado, Graciela and Dominiczak, Anna F and Doney, Alex SF and Drenos, Fotios and Edkins, Sarah and Eicher, John D and Elosua, Roberto and Enroth, Stefan and Erdmann, Jeanette and Eriksson, Per and Esko, Tonu and Evangelou, Evangelos and Evans, Alun and Fall, Tove and Farrall, Martin and Felix, Janine F and Ferrières, Jean and Ferrucci, Luigi and Fornage, Myriam and Forrester, Terrence and Franceschini, Nora and Franco, Oscar H and Franco-Cereceda, Anders and Fraser, Ross M and Ganesh, Santhi K and Gao, He and Gertow, Karl and Gianfagna, Francesco and Gigante, Bruna and Giulianini, Franco and Goel, Anuj and Goodall, Alison H and Goodarzi, Mark O and Gorski, Mathias and Gräßler, Jürgen and Groves, Christopher J and Gudnason, Vilmundur and Gyllensten, Ulf and Hallmans, Göran and Hartikainen, Anna-Liisa and Hassinen, Maija and Havulinna, Aki S and Hayward, Caroline and Hercberg, Serge and Herzig, Karl-Heinz and Hicks, Andrew A and Hingorani, Aroon D and Hirschhorn, Joel N and Hofman, Albert and Holmen, Jostein and Holmen, Oddgeir Lingaas and Hottenga, Jouke-Jan and Howard, Phil and Hsiung, Chao A and Hunt, Steven C and Ikram, M Arfan and Illig, Thomas and Iribarren, Carlos and Jensen, Richard A and Kähönen, Mika and Kang, Hyun Min and Kathiresan, Sekar and Keating, Brendan J and Khaw, Kay-Tee and Kim, Yun Kyoung and Kim, Eric and Kivimaki, Mika and Klopp, Norman and Kolovou, Genovefa and Komulainen, Pirjo and Kooner, Jaspal S and Kosova, Gulum and Krauss, Ronald M and Kuh, Diana and Kutalik, Zoltan and Kuusisto, Johanna and Kvaløy, Kirsti and Lakka, Timo A and Lee, Nanette R and Lee, I-Te and Lee, Wen-Jane and Levy, Daniel and Li, Xiaohui and Liang, Kae-Woei and Lin, Honghuang and Lin, Li and Lindström, Jaana and Lobbens, Stéphane and Männistö, Satu and Müller, Gabriele and Müller-Nurasyid, Martina and Mach, François and Markus, Hugh S and Marouli, Eirini and McCarthy, Mark I and McKenzie, Colin A and Meneton, Pierre and Menni, Cristina and Metspalu, Andres and Mijatovic, Vladan and Moilanen, Leena and Montasser, May E and Morris, Andrew D and Morrison, Alanna C and Mulas, Antonella and Nagaraja, Ramaiah and Narisu, Narisu and Nikus, Kjell and O'Donnell, Christopher J and O'Reilly, Paul F and Ong, Ken K and Paccaud, Fred and Palmer, Cameron D and Parsa, Afshin and Pedersen, Nancy L and Penninx, Brenda W and Perola, Markus and Peters, Annette and Poulter, Neil and Pramstaller, Peter P and Psaty, Bruce M and Quertermous, Thomas and Rao, Dabeeru C and Rasheed, Asif and Rayner, N William and Renström, Frida and Rettig, Rainer and Rice, Kenneth M and Roberts, Robert and Rose, Lynda M and Rossouw, Jacques and Samani, Nilesh J and Sanna, Serena and Saramies, Jouko and Schunkert, Heribert and Sebert, Sylvain and Sheu, Wayne H-H and Shin, Young-Ah and Sim, Xueling and Smit, Johannes H and Smith, Albert V and Sosa, Maria X and Spector, Tim D and Stančáková, Alena and Stanton, Alice V and Stirrups, Kathleen E and Stringham, Heather M and Sundstrom, Johan and Swift, Amy J and Syvänen, Ann-Christine and Tai, E-Shyong and Tanaka, Toshiko and Tarasov, Kirill V and Teumer, Alexander and Thorsteinsdottir, Unnur and Tobin, Martin D and Tremoli, Elena and Uitterlinden, Andre G and Uusitupa, Matti and Vaez, Ahmad and Vaidya, Dhananjay and van Duijn, Cornelia M and van Iperen, Erik PA and Vasan, Ramachandran S and Verwoert, Germaine C and Virtamo, Jarmo and Vitart, Veronique and Voight, Benjamin F and Vollenweider, Peter and Wagner, Aline and Wain, Louise V and Wareham, Nicholas J and Watkins, Hugh and Weder, Alan B and Westra, Harm-Jan and Wilks, Rainford and Wilsgaard, Tom and Wilson, James F and Wong, Tien Y and Yang, Tsun-Po and Yao, Jie and Yengo, Loic and Zhang, Weihua and Zhao, Jing Hua and Zhu, Xiaofeng and Bovet, Pascal and Cooper, Richard S and Mohlke, Karen L and Saleheen, Danish and Lee, Jong-Young and Elliott, Paul and Gierman, Hinco J and Willer, Cristen J and Franke, Lude and Hovingh, G Kees and Taylor, Kent D and Dedoussis, George and Sever, Peter and Wong, Andrew and Lind, Lars and Assimes, Themistocles L and Njølstad, Inger and Schwarz, Peter EH and Langenberg, Claudia and Snieder, Harold and Caulfield, Mark J and Melander, Olle and Laakso, Markku and Saltevo, Juha and Rauramaa, Rainer and Tuomilehto, Jaakko and Ingelsson, Erik and Lehtimäki, Terho and Hveem, Kristian and Palmas, Walter and März, Winfried and Kumari, Meena and Salomaa, Veikko and Chen, Yii-Der I and Rotter, Jerome I and Froguel, Philippe and Jarvelin, Marjo-Riitta and Lakatta, Edward G and Kuulasmaa, Kari and Franks, Paul W and Hamsten, Anders and Wichmann, H-Erich and Palmer, Colin NA and Stefansson, Kari and Ridker, Paul M and Loos, Ruth JF and Chakravarti, Aravinda and Deloukas, Panos and Morris, Andrew P and Newton-Cheh, Christopher and Munroe, Patricia B (2016) The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals. Nature Genetics, 48 (10). pp. 1171-1184. DOI https://doi.org/10.1038/ng.3667
Abstract
To dissect the genetic architecture of blood pressure and assess effects on target organ damage, we analyzed 128,272 SNPs from targeted and genome-wide arrays in 201,529 individuals of European ancestry, and genotypes from an additional 140,886 individuals were used for validation. We identified 66 blood pressure–associated loci, of which 17 were new; 15 harbored multiple distinct association signals. The 66 index SNPs were enriched for cis-regulatory elements, particularly in vascular endothelial cells, consistent with a primary role in blood pressure control through modulation of vascular tone across multiple tissues. The 66 index SNPs combined in a risk score showed comparable effects in 64,421 individuals of non-European descent. The 66-SNP blood pressure risk score was significantly associated with target organ damage in multiple tissues but with minor effects in the kidney. Our findings expand current knowledge of blood pressure–related pathways and highlight tissues beyond the classical renal system in blood pressure regulation.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CHARGE-EchoGen consortium; CHARGE-HF consortium; Wellcome Trust Case Control Consortium; Cells, Cultured; Humans; Hypertension; Microarray Analysis; Blood Pressure; Polymorphism, Single Nucleotide; Genome-Wide Association Study; Asian People; Black People |
| Subjects: | H Social Sciences > H Social Sciences (General) R Medicine > R Medicine (General) |
| Divisions: | Faculty of Social Sciences Faculty of Social Sciences > Institute for Social and Economic Research |
| SWORD Depositor: | Unnamed user with email elements@essex.ac.uk |
| Depositing User: | Unnamed user with email elements@essex.ac.uk |
| Date Deposited: | 23 Feb 2018 13:30 |
| Last Modified: | 30 Oct 2024 21:04 |
| URI: | http://repository.essex.ac.uk/id/eprint/21503 |
Available files
Filename: Ehret The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals 2016 Accepted.pdf