Justice, Anne E and Winkler, Thomas W and Feitosa, Mary F and Graff, Misa and Fisher, Virginia A and Young, Kristin and Barata, Llilda and Deng, Xuan and Czajkowski, Jacek and Hadley, David and Ngwa, Julius S and Ahluwalia, Tarunveer S and Chu, Audrey Y and Heard-Costa, Nancy L and Lim, Elise and Perez, Jeremiah and Eicher, John D and Kutalik, Zoltán and Xue, Luting and Mahajan, Anubha and Renström, Frida and Wu, Joseph and Qi, Qibin and Ahmad, Shafqat and Alfred, Tamuno and Amin, Najaf and Bielak, Lawrence F and Bonnefond, Amelie and Bragg, Jennifer and Cadby, Gemma and Chittani, Martina and Coggeshall, Scott and Corre, Tanguy and Direk, Nese and Eriksson, Joel and Fischer, Krista and Gorski, Mathias and Neergaard Harder, Marie and Horikoshi, Momoko and Huang, Tao and Huffman, Jennifer E and Jackson, Anne U and Justesen, Johanne Marie and Kanoni, Stavroula and Kinnunen, Leena and Kleber, Marcus E and Komulainen, Pirjo and Kumari, Meena and Lim, Unhee and Luan, Jian'an and Lyytikäinen, Leo-Pekka and Mangino, Massimo and Manichaikul, Ani and Marten, Jonathan and Middelberg, Rita PS and Müller-Nurasyid, Martina and Navarro, Pau and Pérusse, Louis and Pervjakova, Natalia and Sarti, Cinzia and Smith, Albert Vernon and Smith, Jennifer A and Stančáková, Alena and Strawbridge, Rona J and Stringham, Heather M and Sung, Yun Ju and Tanaka, Toshiko and Teumer, Alexander and Trompet, Stella and van der Laan, Sander W and van der Most, Peter J and Van Vliet-Ostaptchouk, Jana V and Vedantam, Sailaja L and Verweij, Niek and Vink, Jacqueline M and Vitart, Veronique and Wu, Ying and Yengo, Loic and Zhang, Weihua and Hua Zhao, Jing and Zimmermann, Martina E and Zubair, Niha and Abecasis, Gonçalo R and Adair, Linda S and Afaq, Saima and Afzal, Uzma and Bakker, Stephan JL and Bartz, Traci M and Beilby, John and Bergman, Richard N and Bergmann, Sven and Biffar, Reiner and Blangero, John and Boerwinkle, Eric and Bonnycastle, Lori L and Bottinger, Erwin and Braga, Daniele and Buckley, Brendan M and Buyske, Steve and Campbell, Harry and Chambers, John C and Collins, Francis S and Curran, Joanne E and de Borst, Gert J and de Craen, Anton JM and de Geus, Eco JC and Dedoussis, George and Delgado, Graciela E and den Ruijter, Hester M and Eiriksdottir, Gudny and Eriksson, Anna L and Esko, Tõnu and Faul, Jessica D and Ford, Ian and Forrester, Terrence and Gertow, Karl and Gigante, Bruna and Glorioso, Nicola and Gong, Jian and Grallert, Harald and Grammer, Tanja B and Grarup, Niels and Haitjema, Saskia and Hallmans, Göran and Hamsten, Anders and Hansen, Torben and Harris, Tamara B and Hartman, Catharina A and Hassinen, Maija and Hastie, Nicholas D and Heath, Andrew C and Hernandez, Dena and Hindorff, Lucia and Hocking, Lynne J and Hollensted, Mette and Holmen, Oddgeir L and Homuth, Georg and Jan Hottenga, Jouke and Huang, Jie and Hung, Joseph and Hutri-Kähönen, Nina and Ingelsson, Erik and James, Alan L and Jansson, John-Olov and Jarvelin, Marjo-Riitta and Jhun, Min A and Jørgensen, Marit E and Juonala, Markus and Kähönen, Mika and Karlsson, Magnus and Koistinen, Heikki A and Kolcic, Ivana and Kolovou, Genovefa and Kooperberg, Charles and Krämer, Bernhard K and Kuusisto, Johanna and Kvaløy, Kirsti and Lakka, Timo A and Langenberg, Claudia and Launer, Lenore J and Leander, Karin and Lee, Nanette R and Lind, Lars and Lindgren, Cecilia M and Linneberg, Allan and Lobbens, Stephane and Loh, Marie and Lorentzon, Mattias and Luben, Robert and Lubke, Gitta and Ludolph-Donislawski, Anja and Lupoli, Sara and Madden, Pamela AF and Männikkö, Reija and Marques-Vidal, Pedro and Martin, Nicholas G and McKenzie, Colin A and McKnight, Barbara and Mellström, Dan and Menni, Cristina and Montgomery, Grant W and Musk, AW Bill and Narisu, Narisu and Nauck, Matthias and Nolte, Ilja M and Oldehinkel, Albertine J and Olden, Matthias and Ong, Ken K and Padmanabhan, Sandosh and Peyser, Patricia A and Pisinger, Charlotta and Porteous, David J and Raitakari, Olli T and Rankinen, Tuomo and Rao, DC and Rasmussen-Torvik, Laura J and Rawal, Rajesh and Rice, Treva and Ridker, Paul M and Rose, Lynda M and Bien, Stephanie A and Rudan, Igor and Sanna, Serena and Sarzynski, Mark A and Sattar, Naveed and Savonen, Kai and Schlessinger, David and Scholtens, Salome and Schurmann, Claudia and Scott, Robert A and Sennblad, Bengt and Siemelink, Marten A and Silbernagel, Günther and Slagboom, P Eline and Snieder, Harold and Staessen, Jan A and Stott, David J and Swertz, Morris A and Swift, Amy J and Taylor, Kent D and Tayo, Bamidele O and Thorand, Barbara and Thuillier, Dorothee and Tuomilehto, Jaakko and Uitterlinden, Andre G and Vandenput, Liesbeth and Vohl, Marie-Claude and Völzke, Henry and Vonk, Judith M and Waeber, Gérard and Waldenberger, Melanie and Westendorp, RGJ and Wild, Sarah and Willemsen, Gonneke and Wolffenbuttel, Bruce HR and Wong, Andrew and Wright, Alan F and Zhao, Wei and Zillikens, M Carola and Baldassarre, Damiano and Balkau, Beverley and Bandinelli, Stefania and Böger, Carsten A and Boomsma, Dorret I and Bouchard, Claude and Bruinenberg, Marcel and Chasman, Daniel I and Chen, Yii-DerIda and Chines, Peter S and Cooper, Richard S and Cucca, Francesco and Cusi, Daniele and Faire, Ulf de and Ferrucci, Luigi and Franks, Paul W and Froguel, Philippe and Gordon-Larsen, Penny and Grabe, Hans-Jörgen and Gudnason, Vilmundur and Haiman, Christopher A and Hayward, Caroline and Hveem, Kristian and Johnson, Andrew D and Wouter Jukema, J and Kardia, Sharon LR and Kivimaki, Mika and Kooner, Jaspal S and Kuh, Diana and Laakso, Markku and Lehtimäki, Terho and Marchand, Loic Le and März, Winfried and McCarthy, Mark I and Metspalu, Andres and Morris, Andrew P and Ohlsson, Claes and Palmer, Lyle J and Pasterkamp, Gerard and Pedersen, Oluf and Peters, Annette and Peters, Ulrike and Polasek, Ozren and Psaty, Bruce M and Qi, Lu and Rauramaa, Rainer and Smith, Blair H and Sørensen, Thorkild IA and Strauch, Konstantin and Tiemeier, Henning and Tremoli, Elena and van der Harst, Pim and Vestergaard, Henrik and Vollenweider, Peter and Wareham, Nicholas J and Weir, David R and Whitfield, John B and Wilson, James F and Tyrrell, Jessica and Frayling, Timothy M and Barroso, Inês and Boehnke, Michael and Deloukas, Panagiotis and Fox, Caroline S and Hirschhorn, Joel N and Hunter, David J and Spector, Tim D and Strachan, David P and van Duijn, Cornelia M and Heid, Iris M and Mohlke, Karen L and Marchini, Jonathan and Loos, Ruth JF and Kilpeläinen, Tuomas O and Liu, Ching-Ti and Borecki, Ingrid B and North, Kari E and Cupples, L Adrienne (2017) Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits. Nature Communications, 8 (1). 14977-. DOI https://doi.org/10.1038/ncomms14977
Justice, Anne E and Winkler, Thomas W and Feitosa, Mary F and Graff, Misa and Fisher, Virginia A and Young, Kristin and Barata, Llilda and Deng, Xuan and Czajkowski, Jacek and Hadley, David and Ngwa, Julius S and Ahluwalia, Tarunveer S and Chu, Audrey Y and Heard-Costa, Nancy L and Lim, Elise and Perez, Jeremiah and Eicher, John D and Kutalik, Zoltán and Xue, Luting and Mahajan, Anubha and Renström, Frida and Wu, Joseph and Qi, Qibin and Ahmad, Shafqat and Alfred, Tamuno and Amin, Najaf and Bielak, Lawrence F and Bonnefond, Amelie and Bragg, Jennifer and Cadby, Gemma and Chittani, Martina and Coggeshall, Scott and Corre, Tanguy and Direk, Nese and Eriksson, Joel and Fischer, Krista and Gorski, Mathias and Neergaard Harder, Marie and Horikoshi, Momoko and Huang, Tao and Huffman, Jennifer E and Jackson, Anne U and Justesen, Johanne Marie and Kanoni, Stavroula and Kinnunen, Leena and Kleber, Marcus E and Komulainen, Pirjo and Kumari, Meena and Lim, Unhee and Luan, Jian'an and Lyytikäinen, Leo-Pekka and Mangino, Massimo and Manichaikul, Ani and Marten, Jonathan and Middelberg, Rita PS and Müller-Nurasyid, Martina and Navarro, Pau and Pérusse, Louis and Pervjakova, Natalia and Sarti, Cinzia and Smith, Albert Vernon and Smith, Jennifer A and Stančáková, Alena and Strawbridge, Rona J and Stringham, Heather M and Sung, Yun Ju and Tanaka, Toshiko and Teumer, Alexander and Trompet, Stella and van der Laan, Sander W and van der Most, Peter J and Van Vliet-Ostaptchouk, Jana V and Vedantam, Sailaja L and Verweij, Niek and Vink, Jacqueline M and Vitart, Veronique and Wu, Ying and Yengo, Loic and Zhang, Weihua and Hua Zhao, Jing and Zimmermann, Martina E and Zubair, Niha and Abecasis, Gonçalo R and Adair, Linda S and Afaq, Saima and Afzal, Uzma and Bakker, Stephan JL and Bartz, Traci M and Beilby, John and Bergman, Richard N and Bergmann, Sven and Biffar, Reiner and Blangero, John and Boerwinkle, Eric and Bonnycastle, Lori L and Bottinger, Erwin and Braga, Daniele and Buckley, Brendan M and Buyske, Steve and Campbell, Harry and Chambers, John C and Collins, Francis S and Curran, Joanne E and de Borst, Gert J and de Craen, Anton JM and de Geus, Eco JC and Dedoussis, George and Delgado, Graciela E and den Ruijter, Hester M and Eiriksdottir, Gudny and Eriksson, Anna L and Esko, Tõnu and Faul, Jessica D and Ford, Ian and Forrester, Terrence and Gertow, Karl and Gigante, Bruna and Glorioso, Nicola and Gong, Jian and Grallert, Harald and Grammer, Tanja B and Grarup, Niels and Haitjema, Saskia and Hallmans, Göran and Hamsten, Anders and Hansen, Torben and Harris, Tamara B and Hartman, Catharina A and Hassinen, Maija and Hastie, Nicholas D and Heath, Andrew C and Hernandez, Dena and Hindorff, Lucia and Hocking, Lynne J and Hollensted, Mette and Holmen, Oddgeir L and Homuth, Georg and Jan Hottenga, Jouke and Huang, Jie and Hung, Joseph and Hutri-Kähönen, Nina and Ingelsson, Erik and James, Alan L and Jansson, John-Olov and Jarvelin, Marjo-Riitta and Jhun, Min A and Jørgensen, Marit E and Juonala, Markus and Kähönen, Mika and Karlsson, Magnus and Koistinen, Heikki A and Kolcic, Ivana and Kolovou, Genovefa and Kooperberg, Charles and Krämer, Bernhard K and Kuusisto, Johanna and Kvaløy, Kirsti and Lakka, Timo A and Langenberg, Claudia and Launer, Lenore J and Leander, Karin and Lee, Nanette R and Lind, Lars and Lindgren, Cecilia M and Linneberg, Allan and Lobbens, Stephane and Loh, Marie and Lorentzon, Mattias and Luben, Robert and Lubke, Gitta and Ludolph-Donislawski, Anja and Lupoli, Sara and Madden, Pamela AF and Männikkö, Reija and Marques-Vidal, Pedro and Martin, Nicholas G and McKenzie, Colin A and McKnight, Barbara and Mellström, Dan and Menni, Cristina and Montgomery, Grant W and Musk, AW Bill and Narisu, Narisu and Nauck, Matthias and Nolte, Ilja M and Oldehinkel, Albertine J and Olden, Matthias and Ong, Ken K and Padmanabhan, Sandosh and Peyser, Patricia A and Pisinger, Charlotta and Porteous, David J and Raitakari, Olli T and Rankinen, Tuomo and Rao, DC and Rasmussen-Torvik, Laura J and Rawal, Rajesh and Rice, Treva and Ridker, Paul M and Rose, Lynda M and Bien, Stephanie A and Rudan, Igor and Sanna, Serena and Sarzynski, Mark A and Sattar, Naveed and Savonen, Kai and Schlessinger, David and Scholtens, Salome and Schurmann, Claudia and Scott, Robert A and Sennblad, Bengt and Siemelink, Marten A and Silbernagel, Günther and Slagboom, P Eline and Snieder, Harold and Staessen, Jan A and Stott, David J and Swertz, Morris A and Swift, Amy J and Taylor, Kent D and Tayo, Bamidele O and Thorand, Barbara and Thuillier, Dorothee and Tuomilehto, Jaakko and Uitterlinden, Andre G and Vandenput, Liesbeth and Vohl, Marie-Claude and Völzke, Henry and Vonk, Judith M and Waeber, Gérard and Waldenberger, Melanie and Westendorp, RGJ and Wild, Sarah and Willemsen, Gonneke and Wolffenbuttel, Bruce HR and Wong, Andrew and Wright, Alan F and Zhao, Wei and Zillikens, M Carola and Baldassarre, Damiano and Balkau, Beverley and Bandinelli, Stefania and Böger, Carsten A and Boomsma, Dorret I and Bouchard, Claude and Bruinenberg, Marcel and Chasman, Daniel I and Chen, Yii-DerIda and Chines, Peter S and Cooper, Richard S and Cucca, Francesco and Cusi, Daniele and Faire, Ulf de and Ferrucci, Luigi and Franks, Paul W and Froguel, Philippe and Gordon-Larsen, Penny and Grabe, Hans-Jörgen and Gudnason, Vilmundur and Haiman, Christopher A and Hayward, Caroline and Hveem, Kristian and Johnson, Andrew D and Wouter Jukema, J and Kardia, Sharon LR and Kivimaki, Mika and Kooner, Jaspal S and Kuh, Diana and Laakso, Markku and Lehtimäki, Terho and Marchand, Loic Le and März, Winfried and McCarthy, Mark I and Metspalu, Andres and Morris, Andrew P and Ohlsson, Claes and Palmer, Lyle J and Pasterkamp, Gerard and Pedersen, Oluf and Peters, Annette and Peters, Ulrike and Polasek, Ozren and Psaty, Bruce M and Qi, Lu and Rauramaa, Rainer and Smith, Blair H and Sørensen, Thorkild IA and Strauch, Konstantin and Tiemeier, Henning and Tremoli, Elena and van der Harst, Pim and Vestergaard, Henrik and Vollenweider, Peter and Wareham, Nicholas J and Weir, David R and Whitfield, John B and Wilson, James F and Tyrrell, Jessica and Frayling, Timothy M and Barroso, Inês and Boehnke, Michael and Deloukas, Panagiotis and Fox, Caroline S and Hirschhorn, Joel N and Hunter, David J and Spector, Tim D and Strachan, David P and van Duijn, Cornelia M and Heid, Iris M and Mohlke, Karen L and Marchini, Jonathan and Loos, Ruth JF and Kilpeläinen, Tuomas O and Liu, Ching-Ti and Borecki, Ingrid B and North, Kari E and Cupples, L Adrienne (2017) Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits. Nature Communications, 8 (1). 14977-. DOI https://doi.org/10.1038/ncomms14977
Justice, Anne E and Winkler, Thomas W and Feitosa, Mary F and Graff, Misa and Fisher, Virginia A and Young, Kristin and Barata, Llilda and Deng, Xuan and Czajkowski, Jacek and Hadley, David and Ngwa, Julius S and Ahluwalia, Tarunveer S and Chu, Audrey Y and Heard-Costa, Nancy L and Lim, Elise and Perez, Jeremiah and Eicher, John D and Kutalik, Zoltán and Xue, Luting and Mahajan, Anubha and Renström, Frida and Wu, Joseph and Qi, Qibin and Ahmad, Shafqat and Alfred, Tamuno and Amin, Najaf and Bielak, Lawrence F and Bonnefond, Amelie and Bragg, Jennifer and Cadby, Gemma and Chittani, Martina and Coggeshall, Scott and Corre, Tanguy and Direk, Nese and Eriksson, Joel and Fischer, Krista and Gorski, Mathias and Neergaard Harder, Marie and Horikoshi, Momoko and Huang, Tao and Huffman, Jennifer E and Jackson, Anne U and Justesen, Johanne Marie and Kanoni, Stavroula and Kinnunen, Leena and Kleber, Marcus E and Komulainen, Pirjo and Kumari, Meena and Lim, Unhee and Luan, Jian'an and Lyytikäinen, Leo-Pekka and Mangino, Massimo and Manichaikul, Ani and Marten, Jonathan and Middelberg, Rita PS and Müller-Nurasyid, Martina and Navarro, Pau and Pérusse, Louis and Pervjakova, Natalia and Sarti, Cinzia and Smith, Albert Vernon and Smith, Jennifer A and Stančáková, Alena and Strawbridge, Rona J and Stringham, Heather M and Sung, Yun Ju and Tanaka, Toshiko and Teumer, Alexander and Trompet, Stella and van der Laan, Sander W and van der Most, Peter J and Van Vliet-Ostaptchouk, Jana V and Vedantam, Sailaja L and Verweij, Niek and Vink, Jacqueline M and Vitart, Veronique and Wu, Ying and Yengo, Loic and Zhang, Weihua and Hua Zhao, Jing and Zimmermann, Martina E and Zubair, Niha and Abecasis, Gonçalo R and Adair, Linda S and Afaq, Saima and Afzal, Uzma and Bakker, Stephan JL and Bartz, Traci M and Beilby, John and Bergman, Richard N and Bergmann, Sven and Biffar, Reiner and Blangero, John and Boerwinkle, Eric and Bonnycastle, Lori L and Bottinger, Erwin and Braga, Daniele and Buckley, Brendan M and Buyske, Steve and Campbell, Harry and Chambers, John C and Collins, Francis S and Curran, Joanne E and de Borst, Gert J and de Craen, Anton JM and de Geus, Eco JC and Dedoussis, George and Delgado, Graciela E and den Ruijter, Hester M and Eiriksdottir, Gudny and Eriksson, Anna L and Esko, Tõnu and Faul, Jessica D and Ford, Ian and Forrester, Terrence and Gertow, Karl and Gigante, Bruna and Glorioso, Nicola and Gong, Jian and Grallert, Harald and Grammer, Tanja B and Grarup, Niels and Haitjema, Saskia and Hallmans, Göran and Hamsten, Anders and Hansen, Torben and Harris, Tamara B and Hartman, Catharina A and Hassinen, Maija and Hastie, Nicholas D and Heath, Andrew C and Hernandez, Dena and Hindorff, Lucia and Hocking, Lynne J and Hollensted, Mette and Holmen, Oddgeir L and Homuth, Georg and Jan Hottenga, Jouke and Huang, Jie and Hung, Joseph and Hutri-Kähönen, Nina and Ingelsson, Erik and James, Alan L and Jansson, John-Olov and Jarvelin, Marjo-Riitta and Jhun, Min A and Jørgensen, Marit E and Juonala, Markus and Kähönen, Mika and Karlsson, Magnus and Koistinen, Heikki A and Kolcic, Ivana and Kolovou, Genovefa and Kooperberg, Charles and Krämer, Bernhard K and Kuusisto, Johanna and Kvaløy, Kirsti and Lakka, Timo A and Langenberg, Claudia and Launer, Lenore J and Leander, Karin and Lee, Nanette R and Lind, Lars and Lindgren, Cecilia M and Linneberg, Allan and Lobbens, Stephane and Loh, Marie and Lorentzon, Mattias and Luben, Robert and Lubke, Gitta and Ludolph-Donislawski, Anja and Lupoli, Sara and Madden, Pamela AF and Männikkö, Reija and Marques-Vidal, Pedro and Martin, Nicholas G and McKenzie, Colin A and McKnight, Barbara and Mellström, Dan and Menni, Cristina and Montgomery, Grant W and Musk, AW Bill and Narisu, Narisu and Nauck, Matthias and Nolte, Ilja M and Oldehinkel, Albertine J and Olden, Matthias and Ong, Ken K and Padmanabhan, Sandosh and Peyser, Patricia A and Pisinger, Charlotta and Porteous, David J and Raitakari, Olli T and Rankinen, Tuomo and Rao, DC and Rasmussen-Torvik, Laura J and Rawal, Rajesh and Rice, Treva and Ridker, Paul M and Rose, Lynda M and Bien, Stephanie A and Rudan, Igor and Sanna, Serena and Sarzynski, Mark A and Sattar, Naveed and Savonen, Kai and Schlessinger, David and Scholtens, Salome and Schurmann, Claudia and Scott, Robert A and Sennblad, Bengt and Siemelink, Marten A and Silbernagel, Günther and Slagboom, P Eline and Snieder, Harold and Staessen, Jan A and Stott, David J and Swertz, Morris A and Swift, Amy J and Taylor, Kent D and Tayo, Bamidele O and Thorand, Barbara and Thuillier, Dorothee and Tuomilehto, Jaakko and Uitterlinden, Andre G and Vandenput, Liesbeth and Vohl, Marie-Claude and Völzke, Henry and Vonk, Judith M and Waeber, Gérard and Waldenberger, Melanie and Westendorp, RGJ and Wild, Sarah and Willemsen, Gonneke and Wolffenbuttel, Bruce HR and Wong, Andrew and Wright, Alan F and Zhao, Wei and Zillikens, M Carola and Baldassarre, Damiano and Balkau, Beverley and Bandinelli, Stefania and Böger, Carsten A and Boomsma, Dorret I and Bouchard, Claude and Bruinenberg, Marcel and Chasman, Daniel I and Chen, Yii-DerIda and Chines, Peter S and Cooper, Richard S and Cucca, Francesco and Cusi, Daniele and Faire, Ulf de and Ferrucci, Luigi and Franks, Paul W and Froguel, Philippe and Gordon-Larsen, Penny and Grabe, Hans-Jörgen and Gudnason, Vilmundur and Haiman, Christopher A and Hayward, Caroline and Hveem, Kristian and Johnson, Andrew D and Wouter Jukema, J and Kardia, Sharon LR and Kivimaki, Mika and Kooner, Jaspal S and Kuh, Diana and Laakso, Markku and Lehtimäki, Terho and Marchand, Loic Le and März, Winfried and McCarthy, Mark I and Metspalu, Andres and Morris, Andrew P and Ohlsson, Claes and Palmer, Lyle J and Pasterkamp, Gerard and Pedersen, Oluf and Peters, Annette and Peters, Ulrike and Polasek, Ozren and Psaty, Bruce M and Qi, Lu and Rauramaa, Rainer and Smith, Blair H and Sørensen, Thorkild IA and Strauch, Konstantin and Tiemeier, Henning and Tremoli, Elena and van der Harst, Pim and Vestergaard, Henrik and Vollenweider, Peter and Wareham, Nicholas J and Weir, David R and Whitfield, John B and Wilson, James F and Tyrrell, Jessica and Frayling, Timothy M and Barroso, Inês and Boehnke, Michael and Deloukas, Panagiotis and Fox, Caroline S and Hirschhorn, Joel N and Hunter, David J and Spector, Tim D and Strachan, David P and van Duijn, Cornelia M and Heid, Iris M and Mohlke, Karen L and Marchini, Jonathan and Loos, Ruth JF and Kilpeläinen, Tuomas O and Liu, Ching-Ti and Borecki, Ingrid B and North, Kari E and Cupples, L Adrienne (2017) Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits. Nature Communications, 8 (1). 14977-. DOI https://doi.org/10.1038/ncomms14977
Abstract
Few genome-wide association studies (GWAS) account for environmental exposures, like smoking, potentially impacting the overall trait variance when investigating the genetic contribution to obesity-related traits. Here, we use GWAS data from 51,080 current smokers and 190,178 nonsmokers (87% European descent) to identify loci influencing BMI and central adiposity, measured as waist circumference and waist-to-hip ratio both adjusted for BMI. We identify 23 novel genetic loci, and 9 loci with convincing evidence of gene-smoking interaction (GxSMK) on obesity-related traits. We show consistent direction of effect for all identified loci and significance for 18 novel and for 5 interaction loci in an independent study sample. These loci highlight novel biological functions, including response to oxidative stress, addictive behaviour, and regulatory functions emphasizing the importance of accounting for environment in genetic analyses. Our results suggest that tobacco smoking may alter the genetic susceptibility to overall adiposity and body fat distribution.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Humans; Obesity; Genetic Predisposition to Disease; Body Mass Index; Waist-Hip Ratio; Smoking; Epistasis, Genetic; Phenotype; Polymorphism, Single Nucleotide; Quantitative Trait Loci; Adult; Adiposity; Body Fat Distribution; Waist Circumference; Genome-Wide Association Study |
| Subjects: | H Social Sciences > H Social Sciences (General) R Medicine > R Medicine (General) |
| Divisions: | Faculty of Social Sciences Faculty of Social Sciences > Institute for Social and Economic Research |
| SWORD Depositor: | Unnamed user with email elements@essex.ac.uk |
| Depositing User: | Unnamed user with email elements@essex.ac.uk |
| Date Deposited: | 04 Sep 2018 12:22 |
| Last Modified: | 30 Oct 2024 20:27 |
| URI: | http://repository.essex.ac.uk/id/eprint/22929 |
Available files
Filename: Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits.pdf
Licence: Creative Commons: Attribution 3.0