Items where Author is "Hay, Debbie L"

Pham, Vi and Zhu, Yue and Dal Maso, Emma and Reynolds, Christopher A and Deganutti, Giuseppe and Atanasio, Silvia and Hick, Caroline A and Yang, Dehua and Christopoulos, Arthur and Hay, Debbie L and Furness, Sebastian GB and Wang, Ming-Wei and Wootten, Denise and Sexton, Patrick M (2019) Deconvoluting the Molecular Control of Binding and Signaling at the Amylin 3 Receptor: RAMP3 Alters Signal Propagation through Extracellular Loops of the Calcitonin Receptor. ACS Pharmacology and Translational Science, 2 (3). pp. 183-197. DOI https://doi.org/10.1021/acsptsci.9b00010

dal Maso, Emma and Glukhova, Alisa and Zhu, Yue and Garcia-Nafria, Javier and Tate, Christopher G and Atanasio, Silvia and Reynolds, Christopher A and Ramírez-Aportela, Erney and Carazo, Jose-Maria and Hick, Caroline A and Furness, Sebastian GB and Hay, Debbie L and Liang, Yi-Lynn and Miller, Laurence J and Christopoulos, Arthur and Wang, Ming-Wei and Wootten, Denise and Sexton, Patrick M (2019) The Molecular Control of Calcitonin Receptor Signaling. ACS Pharmacology & Translational Science, 2 (1). pp. 31-51. DOI https://doi.org/10.1021/acsptsci.8b00056

Simms, John and Uddin, Romez and Sakmar, Thomas P and Gingell, Joseph J and Garelja, Michael L and Hay, Debbie L and Brimble, Margaret A and Harris, Paul WR and Reynolds, Christopher A and Poyner, David R (2018) Photoaffinity cross-linking and unnatural amino acid mutagenesis reveal insights into calcitonin gene-related peptide binding to the calcitonin receptor-like receptor/receptor activity-modifying protein 1 (CLR/RAMP1) complex. Biochemistry, 57 (32). pp. 4915-4922. DOI https://doi.org/10.1021/acs.biochem.8b00502

Dal Maso, Emma and Zhu, Yue and Pham, Vi and Reynolds, Christopher A and Deganutti, Giuseppe and Hick, Caroline A and Yang, Dehua and Christopoulos, Arthur and Hay, Debbie L and Wang, Ming-Wei and Sexton, Patrick M and Furness, Sebastian GB and Wootten, Denise (2018) Extracellular loops 2 and 3 of the calcitonin receptor selectively modify agonist binding and efficacy. Biochemical Pharmacology, 150. pp. 214-244. DOI https://doi.org/10.1016/j.bcp.2018.02.005

Woolley, Michael J and Reynolds, Christopher A and Simms, John and Walker, Christopher S and Mobarec, Juan Carlos and Garelja, Michael L and Conner, Alex C and Poyner, David R and Hay, Debbie L (2017) Receptor activity-modifying protein dependent and independent activation mechanisms in the coupling of calcitonin gene-related peptide and adrenomedullin receptors to Gs. Biochemical Pharmacology, 142. pp. 96-110. DOI https://doi.org/10.1016/j.bcp.2017.07.005

Watkins, Harriet A and Chakravarthy, Madhuri and Abhayawardana, Rekhati S and Gingell, Joseph J and Garelja, Michael and Pardamwar, Meenakshi and McElhinney, James MWR and Lathbridge, Alex and Constantine, Arran and Harris, Paul WR and Yuen, Tsz-Ying and Brimble, Margaret A and Barwell, James and Poyner, David R and Woolley, Michael J and Conner, Alex C and Pioszak, Augen A and Reynolds, Christopher A and Hay, Debbie L (2016) Receptor Activity-modifying Proteins 2 and 3 Generate Adrenomedullin Receptor Subtypes with Distinct Molecular Properties. Journal of Biological Chemistry, 291 (22). pp. 11657-11675. DOI https://doi.org/10.1074/jbc.m115.688218

Hay, Debbie L and Walker, Christopher S and Gingell, Joseph J and Ladds, Graham and Reynolds, Christopher A and Poyner, David R (2016) Receptor activity-modifying proteins; multifunctional G protein-coupled receptor accessory proteins. Biochemical Society Transactions, 44 (2). pp. 568-573. DOI https://doi.org/10.1042/BST20150237

Woolley, Michael J and Watkins, Harriet A and Taddese, Bruck and Karakullukcu, Z Gamze and Barwell, James and Smith, Kevin J and Hay, Debbie L and Poyner, David R and Reynolds, Christopher A and Conner, Alex C (2013) The role of ECL2 in CGRP receptor activation: a combined modelling and experimental approach. Journal of The Royal Society Interface, 10 (88). p. 20130589. DOI https://doi.org/10.1098/rsif.2013.0589

Vohra, Shabana and Taddese, Bruck and Conner, Alex C and Poyner, David R and Hay, Debbie L and Barwell, James and Reeves, Philip J and Upton, Graham JG and Reynolds, Christopher A (2013) Similarity between class A and class B G-protein-coupled receptors exemplified through calcitonin gene-related peptide receptor modelling and mutagenesis studies. Journal of The Royal Society Interface, 10 (79). p. 20120846. DOI https://doi.org/10.1098/rsif.2012.0846