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Heavier smoking may lead to a relative increase in waist circumference: evidence for a causal relationship from a Mendelian randomisation meta-analysis. The CARTA consortium: Table 1

Morris, Richard W and Taylor, Amy E and Fluharty, Meg E and Bjørngaard, Johan H and Åsvold, Bjørn Olav and Elvestad Gabrielsen, Maiken and Campbell, Archie and Marioni, Riccardo and Kumari, Meena and Korhonen, Tellervo and Männistö, Satu and Marques-Vidal, Pedro and Kaakinen, Marika and Cavadino, Alana and Postmus, Iris and Husemoen, Lise Lotte N and Skaaby, Tea and Ahluwalia, Tarun Veer Singh and Treur, Jorien L and Willemsen, Gonneke and Dale, Caroline and Wannamethee, S Goya and Lahti, Jari and Palotie, Aarno and Räikkönen, Katri and McConnachie, Alex and Padmanabhan, Sandosh and Wong, Andrew and Dalgård, Christine and Paternoster, Lavinia and Ben-Shlomo, Yoav and Tyrrell, Jessica and Horwood, John and Fergusson, David M and Kennedy, Martin A and Nohr, Ellen A and Christiansen, Lene and Kyvik, Kirsten Ohm and Kuh, Diana and Watt, Graham and Eriksson, Johan G and Whincup, Peter H and Vink, Jacqueline M and Boomsma, Dorret I and Davey Smith, George and Lawlor, Debbie and Linneberg, Allan and Ford, Ian and Jukema, J Wouter and Power, Chris and Hyppönen, Elina and Jarvelin, Marjo-Riitta and Preisig, Martin and Borodulin, Katja and Kaprio, Jaakko and Kivimaki, Mika and Smith, Blair H and Hayward, Caroline and Romundstad, Pål R and Sørensen, Thorkild IA and Munafò, Marcus R and Sattar, Naveed (2015) 'Heavier smoking may lead to a relative increase in waist circumference: evidence for a causal relationship from a Mendelian randomisation meta-analysis. The CARTA consortium: Table 1.' BMJ Open, 5 (8). e008808-e008808. ISSN 2044-6055

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Abstract

Objectives: To investigate, using a Mendelian randomisation approach, whether heavier smoking is associated with a range of regional adiposity phenotypes, in particular those related to abdominal adiposity. Design: Mendelian randomisation meta-analyses using a genetic variant (rs16969968/rs1051730 in the CHRNA5-CHRNA3-CHRNB4 gene region) as a proxy for smoking heaviness, of the associations of smoking heaviness with a range of adiposity phenotypes. Participants:148 731 current, former and neversmokers of European ancestry aged.16 years from 29 studies in the consortium for Causal Analysis Research in Tobacco and Alcohol (CARTA). Primary outcome measures: Waist and hip circumferences, and waist-hip ratio. Results: The data included up to 66 809 never-smokers, 43 009 former smokers and 38 913 current daily cigarette smokers. Among current smokers, for each extra minor allele, the geometric mean was lower for waist circumference by -0.40% (95% CI -0.57% to -0.22%), with effects on hip circumference, waist-hip ratio and body mass index (BMI) being -0.31% (95% CI -0.42% to -0.19), -0.08% (-0.19% to 0.03%) and -0.74% (-0.96% to -0.51%), respectively. In contrast, among never-smokers, these effects were higher by 0.23% (0.09% to 0.36%), 0.17% (0.08% to 0.26%), 0.07% (-0.01% to 0.15%) and 0.35% (0.18% to 0.52%), respectively. When adjusting the three central adiposity measures for BMI, the effects among current smokers changed direction and were higher by 0.14% (0.05% to 0.22%) for waist circumference, 0.02% (-0.05% to 0.08%) for hip circumference and 0.10% (0.02% to 0.19%) for waist-hip ratio, for each extra minor allele. Conclusions: For a given BMI, a gene variant associated with increased cigarette consumption was associated with increased waist circumference. Smoking in an effort to control weight may lead to accumulation of central adiposity.

Item Type: Article
Uncontrolled Keywords: Humans; Body Mass Index; Waist-Hip Ratio; Smoking; Sex Factors; Adolescent; Adult; Aged; Middle Aged; Female; Male; Waist Circumference; Young Adult; Obesity, Abdominal; Mendelian Randomization Analysis
Subjects: H Social Sciences > H Social Sciences (General)
R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
Divisions: Faculty of Social Sciences
Faculty of Social Sciences > Institute for Social and Economic Research
SWORD Depositor: Elements
Depositing User: Elements
Date Deposited: 25 Sep 2015 09:07
Last Modified: 18 Aug 2022 11:09
URI: http://repository.essex.ac.uk/id/eprint/15061

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