Research Repository

Heavier smoking may lead to a relative increase in waist circumference: Evidence for a causal relationship from a Mendelian randomisation meta-analysis. The CARTA consortium

Morris, RW and Taylor, AE and Fluharty, ME and Bjørngaard, JH and Åsvold, BO and Gabrielsen, ME and Campbell, A and Marioni, R and Kumari, M and Korhonen, T and Männistö, S and Marques-Vidal, P and Kaakinen, M and Cavadino, A and Postmus, I and Husemoen, LLN and Skaaby, T and Ahluwalia, TVS and Treur, JL and Willemsen, G and Dale, C and Wannamethee, SG and Lahti, J and Palotie, A and Räikkönen, K and McConnachie, A and Padmanabhan, S and Wong, A and Dalgård, C and Paternoster, L and Ben-Shlomo, Y and Tyrrell, J and Horwood, J and Fergusson, DM and Kennedy, MA and Nohr, EA and Christiansen, L and Kyvik, KO and Kuh, D and Watt, G and Eriksson, JG and Whincup, PH and Vink, JM and Boomsma, DI and Smith, GD and Lawlor, D and Linneberg, A and Ford, I and Jukema, JW and Power, C and Hyppönen, E and Jarvelin, MR and Preisig, M and Borodulin, K and Kaprio, J and Kivimaki, M and Smith, BH and Hayward, C and Romundstad, PR and Sørensen, TIA and Munafò, MR and Sattar, N (2015) 'Heavier smoking may lead to a relative increase in waist circumference: Evidence for a causal relationship from a Mendelian randomisation meta-analysis. The CARTA consortium.' BMJ Open, 5 (8). ISSN 2044-6055

[img]
Preview
Text
BMJ Open-2015-Morris-.pdf - Published Version
Available under License Creative Commons Attribution.

Download (927kB) | Preview

Abstract

Objectives: To investigate, using a Mendelian randomisation approach, whether heavier smoking is associated with a range of regional adiposity phenotypes, in particular those related to abdominal adiposity. Design: Mendelian randomisation meta-analyses using a genetic variant (rs16969968/rs1051730 in the CHRNA5-CHRNA3-CHRNB4 gene region) as a proxy for smoking heaviness, of the associations of smoking heaviness with a range of adiposity phenotypes. Participants:148 731 current, former and neversmokers of European ancestry aged.16 years from 29 studies in the consortium for Causal Analysis Research in Tobacco and Alcohol (CARTA). Primary outcome measures: Waist and hip circumferences, and waist-hip ratio. Results: The data included up to 66 809 never-smokers, 43 009 former smokers and 38 913 current daily cigarette smokers. Among current smokers, for each extra minor allele, the geometric mean was lower for waist circumference by -0.40% (95% CI -0.57% to -0.22%), with effects on hip circumference, waist-hip ratio and body mass index (BMI) being -0.31% (95% CI -0.42% to -0.19), -0.08% (-0.19% to 0.03%) and -0.74% (-0.96% to -0.51%), respectively. In contrast, among never-smokers, these effects were higher by 0.23% (0.09% to 0.36%), 0.17% (0.08% to 0.26%), 0.07% (-0.01% to 0.15%) and 0.35% (0.18% to 0.52%), respectively. When adjusting the three central adiposity measures for BMI, the effects among current smokers changed direction and were higher by 0.14% (0.05% to 0.22%) for waist circumference, 0.02% (-0.05% to 0.08%) for hip circumference and 0.10% (0.02% to 0.19%) for waist-hip ratio, for each extra minor allele. Conclusions: For a given BMI, a gene variant associated with increased cigarette consumption was associated with increased waist circumference. Smoking in an effort to control weight may lead to accumulation of central adiposity.

Item Type: Article
Subjects: H Social Sciences > H Social Sciences (General)
R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
Divisions: Faculty of Social Sciences > Institute for Social and Economic Research
Depositing User: Jim Jamieson
Date Deposited: 25 Sep 2015 09:07
Last Modified: 01 May 2019 00:15
URI: http://repository.essex.ac.uk/id/eprint/15061

Actions (login required)

View Item View Item