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A comprehensive computational model of facilitated diffusion in prokaryotes

Zabet, Nicolae Radu and Adryan, Boris (2012) 'A comprehensive computational model of facilitated diffusion in prokaryotes.' Bioinformatics, 28 (11). pp. 1517-1524. ISSN 1367-4803

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Abstract

Motivation: Gene activity is mediated by site-specific transcription factors (TFs). Their binding to defined regions in the genome determines the rate at which their target genes are transcribed.Results: We present a comprehensive computational model of the search process of TF for their genomic target site(s). The computational model considers: the DNA sequence, various TF species and the interaction of the individual molecules with the DNA or between themselves. We also demonstrate a systematic approach how to parametrize the system using available experimental data. © The Author(s) 2012. Published by Oxford University Press.

Item Type: Article
Uncontrolled Keywords: Escherichia coli; DNA; Thermodynamics; Models, Chemical; Computer Simulation; Transcriptional Activation; Facilitated Diffusion; Lac Repressors
Subjects: Q Science > QC Physics
Q Science > QH Natural history > QH426 Genetics
Divisions: Faculty of Science and Health
Faculty of Science and Health > Life Sciences, School of
SWORD Depositor: Elements
Depositing User: Elements
Date Deposited: 03 Nov 2015 14:44
Last Modified: 18 Aug 2022 12:10
URI: http://repository.essex.ac.uk/id/eprint/15111

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