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A comprehensive computational model of facilitated diffusion in prokaryotes

Zabet, NR and Adryan, B (2012) 'A comprehensive computational model of facilitated diffusion in prokaryotes.' Bioinformatics, 28 (11). 1517 - 1524. ISSN 1367-4803

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Motivation: Gene activity is mediated by site-specific transcription factors (TFs). Their binding to defined regions in the genome determines the rate at which their target genes are transcribed.Results: We present a comprehensive computational model of the search process of TF for their genomic target site(s). The computational model considers: the DNA sequence, various TF species and the interaction of the individual molecules with the DNA or between themselves. We also demonstrate a systematic approach how to parametrize the system using available experimental data. © The Author(s) 2012. Published by Oxford University Press.

Item Type: Article
Subjects: Q Science > QC Physics
Q Science > QH Natural history > QH426 Genetics
Divisions: Faculty of Science and Health > Life Sciences, School of
Depositing User: Nicolae Zabet
Date Deposited: 03 Nov 2015 14:44
Last Modified: 17 Sep 2019 17:15

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