Zabet, Nicolae Radu and Adryan, Boris (2012) A comprehensive computational model of facilitated diffusion in prokaryotes. Bioinformatics, 28 (11). pp. 1517-1524. DOI https://doi.org/10.1093/bioinformatics/bts178
Zabet, Nicolae Radu and Adryan, Boris (2012) A comprehensive computational model of facilitated diffusion in prokaryotes. Bioinformatics, 28 (11). pp. 1517-1524. DOI https://doi.org/10.1093/bioinformatics/bts178
Zabet, Nicolae Radu and Adryan, Boris (2012) A comprehensive computational model of facilitated diffusion in prokaryotes. Bioinformatics, 28 (11). pp. 1517-1524. DOI https://doi.org/10.1093/bioinformatics/bts178
Abstract
<jats:title>Abstract</jats:title> <jats:p>Motivation: Gene activity is mediated by site-specific transcription factors (TFs). Their binding to defined regions in the genome determines the rate at which their target genes are transcribed.</jats:p> <jats:p>Results: We present a comprehensive computational model of the search process of TF for their genomic target site(s). The computational model considers: the DNA sequence, various TF species and the interaction of the individual molecules with the DNA or between themselves. We also demonstrate a systematic approach how to parametrize the system using available experimental data.</jats:p> <jats:p>Contact: n.r.zabet@gen.cam.ac.uk</jats:p> <jats:p>Supplementary information: Supplementary data are available at Bioinformatics online.</jats:p>
Item Type: | Article |
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Uncontrolled Keywords: | Escherichia coli; DNA; Thermodynamics; Models, Chemical; Computer Simulation; Transcriptional Activation; Facilitated Diffusion; Lac Repressors |
Subjects: | Q Science > QC Physics Q Science > QH Natural history > QH426 Genetics |
Divisions: | Faculty of Science and Health Faculty of Science and Health > Life Sciences, School of |
SWORD Depositor: | Unnamed user with email elements@essex.ac.uk |
Depositing User: | Unnamed user with email elements@essex.ac.uk |
Date Deposited: | 03 Nov 2015 14:44 |
Last Modified: | 30 Oct 2024 16:10 |
URI: | http://repository.essex.ac.uk/id/eprint/15111 |
Available files
Filename: Bioinformatics-2012-Zabet-1517-24.pdf
Licence: Creative Commons: Attribution 3.0