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Negative feedback and physical limits of genes

Zabet, Nicolae Radu (2011) 'Negative feedback and physical limits of genes.' Journal of Theoretical Biology, 284 (1). pp. 82-91. ISSN 0022-5193

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This paper compares the auto-repressed gene to a simple one (a gene without auto-regulation) in terms of response time and output noise under the assumption of fixed metabolic cost. The analysis shows that, in the case of non-vanishing leak expression rate, the negative feedback reduces both the switching on and switching off times of a gene. The noise of the auto-repressed gene will be lower than the one of the simple gene only for low leak expression rates. Summing up, for low, but non-vanishing leak expression rates, the auto-repressed gene is both faster and less noisier compared to the simple one. © 2011 Elsevier Ltd.

Item Type: Article
Uncontrolled Keywords: Auto-repression; Output noise; Response time; Metabolic cost; Trade-off
Subjects: Q Science > QC Physics
Q Science > QH Natural history > QH426 Genetics
Divisions: Faculty of Science and Health
Faculty of Science and Health > Life Sciences, School of
SWORD Depositor: Elements
Depositing User: Elements
Date Deposited: 04 Dec 2015 17:52
Last Modified: 18 Aug 2022 12:10

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