Zabet, Nicolae Radu (2011) Negative feedback and physical limits of genes. Journal of Theoretical Biology, 284 (1). pp. 82-91. DOI https://doi.org/10.1016/j.jtbi.2011.06.021
Zabet, Nicolae Radu (2011) Negative feedback and physical limits of genes. Journal of Theoretical Biology, 284 (1). pp. 82-91. DOI https://doi.org/10.1016/j.jtbi.2011.06.021
Zabet, Nicolae Radu (2011) Negative feedback and physical limits of genes. Journal of Theoretical Biology, 284 (1). pp. 82-91. DOI https://doi.org/10.1016/j.jtbi.2011.06.021
Abstract
This paper compares the auto-repressed gene to a simple one (a gene without auto-regulation) in terms of response time and output noise under the assumption of fixed metabolic cost. The analysis shows that, in the case of non-vanishing leak expression rate, the negative feedback reduces both the switching on and switching off times of a gene. The noise of the auto-repressed gene will be lower than the one of the simple gene only for low leak expression rates. Summing up, for low, but non-vanishing leak expression rates, the auto-repressed gene is both faster and less noisier compared to the simple one. © 2011 Elsevier Ltd.
Item Type: | Article |
---|---|
Uncontrolled Keywords: | Auto-repression; Output noise; Response time; Metabolic cost; Trade-off |
Subjects: | Q Science > QC Physics Q Science > QH Natural history > QH426 Genetics |
Divisions: | Faculty of Science and Health Faculty of Science and Health > Life Sciences, School of |
SWORD Depositor: | Unnamed user with email elements@essex.ac.uk |
Depositing User: | Unnamed user with email elements@essex.ac.uk |
Date Deposited: | 04 Dec 2015 17:52 |
Last Modified: | 30 Oct 2024 16:10 |
URI: | http://repository.essex.ac.uk/id/eprint/15122 |