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Facilitated diffusion buffers noise in gene expression

Schoech, Armin P and Zabet, Nicolae Radu (2014) 'Facilitated diffusion buffers noise in gene expression.' Physical Review E, 90 (3). 032701-. ISSN 1539-3755


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Transcription factors perform facilitated diffusion [three-dimensional (3D) diffusion in the cytosol and 1D diffusion on the DNA] when binding to their target sites to regulate gene expression. Here, we investigated the influence of this binding mechanism on the noise in gene expression. Our results showed that, for biologically relevant parameters, the binding process can be represented by a two-state Markov model and that the accelerated target finding due to facilitated diffusion leads to a reduction in both the mRNA and the protein noise.

Item Type: Article
Uncontrolled Keywords: Transcription Factors; Buffers; Gene Expression Regulation; Models, Genetic; Facilitated Diffusion; Lac Repressors
Subjects: Q Science > QC Physics
Q Science > QH Natural history > QH426 Genetics
Divisions: Faculty of Science and Health
Faculty of Science and Health > Life Sciences, School of
SWORD Depositor: Elements
Depositing User: Elements
Date Deposited: 22 Oct 2015 12:03
Last Modified: 18 Aug 2022 12:10

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