Schoech, Armin P and Zabet, Nicolae Radu (2014) Facilitated diffusion buffers noise in gene expression. Physical Review E, 90 (3). 032701-. DOI https://doi.org/10.1103/physreve.90.032701
Schoech, Armin P and Zabet, Nicolae Radu (2014) Facilitated diffusion buffers noise in gene expression. Physical Review E, 90 (3). 032701-. DOI https://doi.org/10.1103/physreve.90.032701
Schoech, Armin P and Zabet, Nicolae Radu (2014) Facilitated diffusion buffers noise in gene expression. Physical Review E, 90 (3). 032701-. DOI https://doi.org/10.1103/physreve.90.032701
Abstract
Transcription factors perform facilitated diffusion [three-dimensional (3D) diffusion in the cytosol and 1D diffusion on the DNA] when binding to their target sites to regulate gene expression. Here, we investigated the influence of this binding mechanism on the noise in gene expression. Our results showed that, for biologically relevant parameters, the binding process can be represented by a two-state Markov model and that the accelerated target finding due to facilitated diffusion leads to a reduction in both the mRNA and the protein noise.
Item Type: | Article |
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Uncontrolled Keywords: | Transcription Factors; Buffers; Gene Expression Regulation; Models, Genetic; Facilitated Diffusion; Lac Repressors |
Subjects: | Q Science > QC Physics Q Science > QH Natural history > QH426 Genetics |
Divisions: | Faculty of Science and Health Faculty of Science and Health > Life Sciences, School of |
SWORD Depositor: | Unnamed user with email elements@essex.ac.uk |
Depositing User: | Unnamed user with email elements@essex.ac.uk |
Date Deposited: | 22 Oct 2015 12:03 |
Last Modified: | 30 Oct 2024 16:10 |
URI: | http://repository.essex.ac.uk/id/eprint/15126 |
Available files
Filename: OA1462_final_PhysRevE.90.pdf