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Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses

Okbay, A and Baselmans, BML and De Neve, JE and Turley, P and Nivard, MG and Fontana, MA and Meddens, SFW and Linnér, RK and Rietveld, CA and Derringer, J and Gratten, J and Lee, JJ and Liu, JZ and De Vlaming, R and SAhluwalia, T and Buchwald, J and Cavadino, A and Frazier-Wood, AC and Furlotte, NA and Garfield, V and Geisel, MH and Gonzalez, JR and Haitjema, S and Karlsson, R and Der Laan, SW and Ladwig, KH and Lahti, J and Van Der Lee, SJ and Lind, PA and Liu, T and Matteson, L and Mihailov, E and Miller, MB and CMinica, C and MNolte, I and Mook-Kanamori, D and Van Der Most, PJ and Oldmeadow, C and Qian, Y and Raitakari, O and Rawal, R and Realo, A and Rueedi, R and Schmidt, B and Smith, AV and Stergiakouli, E and Tanaka, T and Taylor, K and Wedenoja, J and Wellmann, J and Westra, HJ and MWillems, S and Zhao, W and Study, LLC and Amin, N and Bakshi, A and Boyle, PA and Cherney, S and Cox, SR and Davies, G and Davis, OSP and Ding, J and Direk, N and Eibich, P and Emeny, RT and Fatemifar, G and Faul, JD and Ferrucci, L (2016) 'Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses.' Nature Genetics, 48 (6). 624 - 633. ISSN 1061-4036

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Abstract

© 2016 Nature America, Inc. Very few genetic variants have been associated with depression and neuroticism, likely because of limitations on sample size in previous studies. Subjective well-being, a phenotype that is genetically correlated with both of these traits, has not yet been studied with genome-wide data. We conducted genome-wide association studies of three phenotypes: subjective well-being (n = 298,420), depressive symptoms (n = 161,460), and neuroticism (n = 170,911). We identify 3 variants associated with subjective well-being, 2 variants associated with depressive symptoms, and 11 variants associated with neuroticism, including 2 inversion polymorphisms. The two loci associated with depressive symptoms replicate in an independent depression sample. Joint analyses that exploit the high genetic correlations between the phenotypes (P = 0.8) strengthen the overall credibility of the findings and allow us to identify additional variants. Across our phenotypes, loci regulating expression in central nervous system and adrenal or pancreas tissues are strongly enriched for association.

Item Type: Article
Subjects: Q Science > QH Natural history > QH426 Genetics
Divisions: Faculty of Social Sciences > Institute for Social and Economic Research
Depositing User: Jim Jamieson
Date Deposited: 13 Jul 2016 10:10
Last Modified: 23 Jan 2019 00:18
URI: http://repository.essex.ac.uk/id/eprint/17107

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