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Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses

Okbay, Aysu and Baselmans, Bart ML and De Neve, Jan-Emmanuel and Turley, Patrick and Nivard, Michel G and Fontana, Mark Alan and Meddens, S Fleur W and Linnér, Richard Karlsson and Rietveld, Cornelius A and Derringer, Jaime and Gratten, Jacob and Lee, James J and Liu, Jimmy Z and de Vlaming, Ronald and Ahluwalia, Tarunveer S and Buchwald, Jadwiga and Cavadino, Alana and Frazier-Wood, Alexis C and Furlotte, Nicholas A and Garfield, Victoria and Geisel, Marie Henrike and Gonzalez, Juan R and Haitjema, Saskia and Karlsson, Robert and van der Laan, Sander W and Ladwig, Karl-Heinz and Lahti, Jari and van der Lee, Sven J and Lind, Penelope A and Liu, Tian and Matteson, Lindsay and Mihailov, Evelin and Miller, Michael B and Minica, Camelia C and Nolte, Ilja M and Mook-Kanamori, Dennis and van der Most, Peter J and Oldmeadow, Christopher and Qian, Yong and Raitakari, Olli and Rawal, Rajesh and Realo, Anu and Rueedi, Rico and Schmidt, Börge and Smith, Albert V and Stergiakouli, Evie and Tanaka, Toshiko and Taylor, Kent and Thorleifsson, Gudmar and Wedenoja, Juho and Wellmann, Juergen and Westra, Harm-Jan and Willems, Sara M and Zhao, Wei and Amin, Najaf and Bakshi, Andrew and Bergmann, Sven and Bjornsdottir, Gyda and Boyle, Patricia A and Cherney, Samantha and Cox, Simon R and Davies, Gail and Davis, Oliver SP and Ding, Jun and Direk, Nese and Eibich, Peter and Emeny, Rebecca T and Fatemifar, Ghazaleh and Faul, Jessica D and Ferrucci, Luigi and Forstner, Andreas J and Gieger, Christian and Gupta, Richa and Harris, Tamara B and Harris, Juliette M and Holliday, Elizabeth G and Hottenga, Jouke-Jan and De Jager, Philip L and Kaakinen, Marika A and Kajantie, Eero and Karhunen, Ville and Kolcic, Ivana and Kumari, Meena and Launer, Lenore J and Franke, Lude and Li-Gao, Ruifang and Liewald, David C and Koini, Marisa and Loukola, Anu and Marques-Vidal, Pedro and Montgomery, Grant W and Mosing, Miriam A and Paternoster, Lavinia and Pattie, Alison and Petrovic, Katja E and Pulkki-Råback, Laura and Quaye, Lydia and Räikkönen, Katri and Rudan, Igor and Scott, Rodney J and Smith, Jennifer A and Sutin, Angelina R and Trzaskowski, Maciej and Vinkhuyzen, Anna E and Yu, Lei and Zabaneh, Delilah and Attia, John R and Bennett, David A and Berger, Klaus and Bertram, Lars and Boomsma, Dorret I and Snieder, Harold and Chang, Shun-Chiao and Cucca, Francesco and Deary, Ian J and van Duijn, Cornelia M and Eriksson, Johan G and Bültmann, Ute and de Geus, Eco JC and Groenen, Patrick JF and Gudnason, Vilmundur and Hansen, Torben and Hartman, Catharine A and Haworth, Claire MA and Hayward, Caroline and Heath, Andrew C and Hinds, David A and Hyppönen, Elina and Iacono, William G and Järvelin, Marjo-Riitta and Jöckel, Karl-Heinz and Kaprio, Jaakko and Kardia, Sharon LR and Keltikangas-Järvinen, Liisa and Kraft, Peter and Kubzansky, Laura D and Lehtimäki, Terho and Magnusson, Patrik KE and Martin, Nicholas G and McGue, Matt and Metspalu, Andres and Mills, Melinda and de Mutsert, Renée and Oldehinkel, Albertine J and Pasterkamp, Gerard and Pedersen, Nancy L and Plomin, Robert and Polasek, Ozren and Power, Christine and Rich, Stephen S and Rosendaal, Frits R and den Ruijter, Hester M and Schlessinger, David and Schmidt, Helena and Svento, Rauli and Schmidt, Reinhold and Alizadeh, Behrooz Z and Sørensen, Thorkild IA and Spector, Tim D and Starr, John M and Stefansson, Kari and Steptoe, Andrew and Terracciano, Antonio and Thorsteinsdottir, Unnur and Thurik, A Roy and Timpson, Nicholas J and Tiemeier, Henning and Uitterlinden, André G and Vollenweider, Peter and Wagner, Gert G and Weir, David R and Yang, Jian and Conley, Dalton C and Smith, George Davey and Hofman, Albert and Johannesson, Magnus and Laibson, David I and Medland, Sarah E and Meyer, Michelle N and Pickrell, Joseph K and Esko, Tõnu and Krueger, Robert F and Beauchamp, Jonathan P and Koellinger, Philipp D and Benjamin, Daniel J and Bartels, Meike and Cesarini, David (2016) 'Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses.' Nature Genetics, 48 (6). pp. 624-633. ISSN 1061-4036

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Abstract

Very few genetic variants have been associated with depression and neuroticism, likely because of limitations on sample size in previous studies. Subjective well-being, a phenotype that is genetically correlated with both of these traits, has not yet been studied with genome-wide data. We conducted genome-wide association studies of three phenotypes: subjective well-being (n = 298,420), depressive symptoms (n = 161,460), and neuroticism (n = 170,911). We identify 3 variants associated with subjective well-being, 2 variants associated with depressive symptoms, and 11 variants associated with neuroticism, including 2 inversion polymorphisms. The two loci associated with depressive symptoms replicate in an independent depression sample. Joint analyses that exploit the high genetic correlations between the phenotypes (P = 0.8) strengthen the overall credibility of the findings and allow us to identify additional variants. Across our phenotypes, loci regulating expression in central nervous system and adrenal or pancreas tissues are strongly enriched for association.

Item Type: Article
Uncontrolled Keywords: LifeLines Cohort Study; Humans; Bayes Theorem; Depression; Anxiety Disorders; Phenotype; Polymorphism, Single Nucleotide; Genome-Wide Association Study; Neuroticism
Subjects: Q Science > QH Natural history > QH426 Genetics
Divisions: Faculty of Social Sciences
Faculty of Social Sciences > Institute for Social and Economic Research
SWORD Depositor: Elements
Depositing User: Elements
Date Deposited: 13 Jul 2016 10:10
Last Modified: 18 Aug 2022 11:09
URI: http://repository.essex.ac.uk/id/eprint/17107

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