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Work-family life courses and markers of stress and inflammation in mid-life: evidence from the National Child Development Study.

Lacey, Rebecca E and Sacker, Amanda and Kumari, Meena and Worts, Diana and McDonough, Peggy and Booker, Cara and McMunn, Anne (2016) 'Work-family life courses and markers of stress and inflammation in mid-life: evidence from the National Child Development Study.' Int J Epidemiol, 45 (4). 1247 - 1259. ISSN 1464-3685

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BACKGROUND: This study investigated associations between work-family life courses and biomarkers of inflammation and stress in mid-life among British men and women. Gender differences in these associations were also explored. METHODS: A novel statistical method-multi-channel sequence analysis-defined work-family life courses between the ages of 16 and 42 years, combining annual information on work, partnership and parenthood. Associations between work-family life courses and inflammation [C-reactive protein (CRP), fibrinogen and von Willebrand factor] and cortisol at age 44/45 years were tested using multivariate linear regression using multiply-imputed data on almost 6500 participants from the National Child Development Study 1958 British birth cohort. RESULTS: Compared with those who combined strong ties to paid work with later transitions to stable family lives ('Work, later family' group), 'Teen parents' had higher CRP [40.6% higher, 95% confidence interval (CI): 5.6, 87.0] and fibrinogen (7.8% higher, 95% CI: 2.3, 13.5) levels, and homemakers ('No paid work, early family') had raised fibrinogen levels (4.7% higher, 95% CI: 0.7, 9.0), independent of childhood health and socioeconomic position, adult socioeconomic position, health behaviours and body mass index (BMI). Those who combined later transitions to stable family ties with a career break for childrearing had higher post-waking cortisol than the 'Work, later family' group; however, no associations were seen for other work-family types, therefore suggesting a null finding with cortisol. No statistically significant gender interactions in associations between work-family types and inflammatory or cortisol outcomes were found. CONCLUSIONS: Work-family life courses characterised by early parenthood or weak work ties were associated with a raised risk profile in relation to chronic inflammation.

Item Type: Article
Uncontrolled Keywords: National Child Development Study, cortisol, inflammation, life course, parenthood, partnerships, sequence analysis, work
Subjects: H Social Sciences > H Social Sciences (General)
R Medicine > R Medicine (General)
Divisions: Faculty of Social Sciences > Institute for Social and Economic Research
Depositing User: Jim Jamieson
Date Deposited: 08 Dec 2016 11:11
Last Modified: 17 Aug 2017 17:21

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