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Genome-wide physical activity interactions in adiposity ― A meta-analysis of 200,452 adults

Graff, M and Scott, RA and Justice, AE and Young, KL and Feitosa, MF and Barata, L and Winkler, TW and Chu, AY and Mahajan, A and Hadley, D and Xue, L and Workalemahu, T and Heard-Costa, NL and den Hoed, M and Ahluwalia, TS and Qi, Q and Ngwa, JS and Renström, F and Quaye, L and Eicher, JD and Hayes, JE and Cornelis, M and Kutalik, Z and Lim, E and Luan, J and Huffman, JE and Zhang, W and Zhao, W and Griffin, PJ and Haller, T and Ahmad, S and Marques-Vidal, PM and Bien, S and Yengo, L and Teumer, A and Smith, AV and Kumari, M and Harder, MN and Justesen, JM and Kleber, ME and Hollensted, M and Lohman, K and Rivera, NV and Whitfield, JB and Zhao, JH and Stringham, HM and Lyytikäinen, LP and Huppertz, C and Willemsen, G and Peyrot, WJ and Wu, Y and Kristiansson, K and Demirkan, A and Fornage, M and Hassinen, M and Bielak, LF and Cadby, G and Tanaka, T and Mägi, R and van der Most, PJ and Jackson, AU and Bragg-Gresham, JL and Vitart, V and Marten, J and Navarro, P and Bellis, C and Pasko, D and Johansson, Å and Snitker, S and Cheng, YC and Eriksson, J and Lim, U and Aadahl, M and Adair, LS (2017) 'Genome-wide physical activity interactions in adiposity ― A meta-analysis of 200,452 adults.' PLoS Genetics, 13 (4). ISSN 1553-7390

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Abstract

© 2017 Public Library of Science.All rights reserved. Physical activity (PA) may modify the genetic effects that give rise to increased risk of obesity. To identify adiposity loci whose effects are modified by PA, we performed genome-wide interaction meta-analyses of BMI and BMI-adjusted waist circumference and waist-hip ratio from up to 200,452 adults of European (n = 180,423) or other ancestry (n = 20,029). We standardized PA by categorizing it into a dichotomous variable where, on average, 23% of participants were categorized as inactive and 77% as physically active. While we replicate the interaction with PA for the strongest known obesity-risk locus in the FTO gene, of which the effect is attenuated by ~30% in physically active individuals compared to inactive individuals, we do not identify additional loci that are sensitive to PA. In additional genome-wide meta-analyses adjusting for PA and interaction with PA, we identify 11 novel adiposity loci, suggesting that accounting for PA or other environmental factors that contribute to variation in adiposity may facilitate gene discovery.

Item Type: Article
Subjects: H Social Sciences > H Social Sciences (General)
R Medicine > R Medicine (General)
Divisions: Faculty of Social Sciences > Institute for Social and Economic Research
Depositing User: Jim Jamieson
Date Deposited: 22 Jun 2017 15:49
Last Modified: 17 Aug 2017 17:16
URI: http://repository.essex.ac.uk/id/eprint/19918

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