Graff, M and Scott, RA and Justice, AE and Young, KL and Feitosa, MF and Winkler, TW and Barata, L and Chu, AY and Mahajan, A and Hadley, D and Xue, L and Workalemahu, T and Heard-Costa, NL and den Hoed, M and Ahluwalia, TS and Qi, Q and Ngwa, JS and Renstr�m, F and Quaye, L and Eicher, JD and Hayes, JE and Cornelis, M and Kutalik, Z and Lim, E and Luan, J and Huffman, JE and Zhang, W and Zhao, W and Griffin, PJ and Haller, T and Ahmad, S and Marques-Vidal, PM and Bien, S and Yengo, L and Teumer, A and Smith, AV and Kumari, M and Harder, MN and Justesen, JM and Kleber, ME and Hollensted, M and Lohman, K and Rivera, NV and Whitfield, JB and Zhao, JH and Stringham, HM and Lyytik�inen, L and Huppertz, C and Willemsen, G and Peyrot, WJ and Wu, Y and Kristiansson, K and Demirkan, A and Fornage, M and Hassinen, M and Bielak, LF and Cadby, G and Tanaka, T and M�gi, R and van der Most, PJ and Jackson, AU and Bragg-Gresham, JL and Vitart, V and Marten, J and Navarro, P and Bellis, C and Pasko, D and Johansson and Snitker, S and Cheng, Y and Eriksson, J and Lim, U and Aadahl, M and Adair, LS and Amin, N and Balkau, B and Auvinen, J and Beilby, J and Bergman, RN and Bergmann, S and Bertoni, AG and Blangero, J and Bonnefond, A and Bonnycastle, LL and Borja, JB and Brage, S and Busonero, F and Buyske, S and Campbell, H and Chines, PS and Collins, FS and Corre, T and Smith, GD and Delgado, GE and Dueker, N and D�rr, M and Ebeling, T and Eiriksdottir, G and Esko, T and Faul, JD and Fu, M and F�rch, K and Gieger, C and Gl�ser, S and Gong, J and Gordon-Larsen, P and Grallert, H and Grammer, TB and Grarup, N and van Grootheest, G and Harald, K and Hastie, ND and Havulinna, AS and Hernandez, D and Hindorff, L and Hocking, LJ and Holmens, OL and Holzapfel, C and Hottenga, JJ and Huang, J and Huang, T and Hui, J and Huth, C and Hutri-K�h�nen, N and James, AL and Jansson, J and Jhun, MA and Juonala, M and Kinnunen, L and Koistinen, HA and Kolcic, I and Komulainen, P and Kuusisto, J and Kval�y, K and K�h�nen, M and Lakka, TA and Launer, LJ and Lehne, B and Lindgren, CM and Lorentzon, M and Luben, R and Marre, M and Milaneschi, Y and Monda, KL and Montgomery, GW and De Moor, MHM and Mulas, A and M�ller-Nurasyid, M and Musk, AW and M�nnikk�, R and M�nnist�, S and Narisu, N and Nauck, M and Nettleton, JA and Nolte, IM and Oldehinkel, AJ and Olden, M and Ong, KK and Padmanabhan, S and Paternoster, L and Perez, J and Perola, M and Peters, A and Peters, U and Peyser, PA and Prokopenko, I and Puolijoki, H and Raitakari, OT and Rankinen, T and Rasmussen-Torvik, LJ and Rawal, R and Ridker, PM and Rose, LM and Rudan, I and Sarti, C and Sarzynski, MA and Savonen, K and Scott, WR and Sanna, S and Shuldiner, AR and Sidney, S and Silbernagel, G and Smith, BH and Smith, JA and Snieder, H and Stan?�kov�, A and Sternfeld, B and Swift, AJ and Tammelin, T and Tan, S and Thorand, B and Thuillier, D and Vandenput, L and Vestergaard, H and van Vliet-Ostaptchouk, JV and Vohl, M and V�lker, U and Waeber, G and Walker, M and Wild, S and Wong, A and Wright, AF and Zillikens, MC and Zubair, N and Haiman, CA and Lemarchand, L and Gyllensten, U and Ohlsson, C and Hofman, A and Rivadeneira, F and Uitterlinden, AG and P�russe, L and Wilson, JF and Hayward, C and Polasek, O and Cucca, F and Hveem, K and Hartman, CA and T�njes, A and Bandinelli, S and Palmer, LJ and Kardia, SLR and Rauramaa, R and S�rensen, TIA and Tuomilehto, J and Salomaa, V and Penninx, BWJH and de Geus, EJC and Boomsma, DI and Lehtim�ki, T and Mangino, M and Laakso, M and Bouchard, C and Martin, NG and Kuh, D and Liu, Y and Linneberg, A and M�rz, W and Strauch, K and Kivim�ki, M and Harris, TB and Gudnason, V and V�lzke, H and Qi, L and J�rvelin, M and Chambers, JC and Kooner, JS and Froguel, P and Kooperberg, C and Vollenweider, P and Hallmans, G and Hansen, T and Pedersen, O and Metspalu, A and Wareham, NJ and Langenberg, C and Weir, DR and Porteous, DJ and Boerwinkle, E and Chasman, DI and Abecasis, GR and Barroso, I and McCarthy, MI and Frayling, TM and O?Connell, JR and van Duijn, CM and Boehnke, M and Heid, IM and Mohlke, KL and Strachan, DP and Fox, CS and Liu, C and Hirschhorn, JN and Klein, RJ and Johnson, AD and Borecki, IB and Franks, PW and North, KE and Cupples, LA and Loos, RJF and Kilpel�inen, TO (2017) Genome-wide physical activity interactions in adiposity ? A meta-analysis of 200,452 adults. PLoS Genetics, 13 (4). creators-Kumari=3AMeena=3A=3A. DOI https://doi.org/10.1371/journal.pgen.1006528
Graff, M and Scott, RA and Justice, AE and Young, KL and Feitosa, MF and Winkler, TW and Barata, L and Chu, AY and Mahajan, A and Hadley, D and Xue, L and Workalemahu, T and Heard-Costa, NL and den Hoed, M and Ahluwalia, TS and Qi, Q and Ngwa, JS and Renstr�m, F and Quaye, L and Eicher, JD and Hayes, JE and Cornelis, M and Kutalik, Z and Lim, E and Luan, J and Huffman, JE and Zhang, W and Zhao, W and Griffin, PJ and Haller, T and Ahmad, S and Marques-Vidal, PM and Bien, S and Yengo, L and Teumer, A and Smith, AV and Kumari, M and Harder, MN and Justesen, JM and Kleber, ME and Hollensted, M and Lohman, K and Rivera, NV and Whitfield, JB and Zhao, JH and Stringham, HM and Lyytik�inen, L and Huppertz, C and Willemsen, G and Peyrot, WJ and Wu, Y and Kristiansson, K and Demirkan, A and Fornage, M and Hassinen, M and Bielak, LF and Cadby, G and Tanaka, T and M�gi, R and van der Most, PJ and Jackson, AU and Bragg-Gresham, JL and Vitart, V and Marten, J and Navarro, P and Bellis, C and Pasko, D and Johansson and Snitker, S and Cheng, Y and Eriksson, J and Lim, U and Aadahl, M and Adair, LS and Amin, N and Balkau, B and Auvinen, J and Beilby, J and Bergman, RN and Bergmann, S and Bertoni, AG and Blangero, J and Bonnefond, A and Bonnycastle, LL and Borja, JB and Brage, S and Busonero, F and Buyske, S and Campbell, H and Chines, PS and Collins, FS and Corre, T and Smith, GD and Delgado, GE and Dueker, N and D�rr, M and Ebeling, T and Eiriksdottir, G and Esko, T and Faul, JD and Fu, M and F�rch, K and Gieger, C and Gl�ser, S and Gong, J and Gordon-Larsen, P and Grallert, H and Grammer, TB and Grarup, N and van Grootheest, G and Harald, K and Hastie, ND and Havulinna, AS and Hernandez, D and Hindorff, L and Hocking, LJ and Holmens, OL and Holzapfel, C and Hottenga, JJ and Huang, J and Huang, T and Hui, J and Huth, C and Hutri-K�h�nen, N and James, AL and Jansson, J and Jhun, MA and Juonala, M and Kinnunen, L and Koistinen, HA and Kolcic, I and Komulainen, P and Kuusisto, J and Kval�y, K and K�h�nen, M and Lakka, TA and Launer, LJ and Lehne, B and Lindgren, CM and Lorentzon, M and Luben, R and Marre, M and Milaneschi, Y and Monda, KL and Montgomery, GW and De Moor, MHM and Mulas, A and M�ller-Nurasyid, M and Musk, AW and M�nnikk�, R and M�nnist�, S and Narisu, N and Nauck, M and Nettleton, JA and Nolte, IM and Oldehinkel, AJ and Olden, M and Ong, KK and Padmanabhan, S and Paternoster, L and Perez, J and Perola, M and Peters, A and Peters, U and Peyser, PA and Prokopenko, I and Puolijoki, H and Raitakari, OT and Rankinen, T and Rasmussen-Torvik, LJ and Rawal, R and Ridker, PM and Rose, LM and Rudan, I and Sarti, C and Sarzynski, MA and Savonen, K and Scott, WR and Sanna, S and Shuldiner, AR and Sidney, S and Silbernagel, G and Smith, BH and Smith, JA and Snieder, H and Stan?�kov�, A and Sternfeld, B and Swift, AJ and Tammelin, T and Tan, S and Thorand, B and Thuillier, D and Vandenput, L and Vestergaard, H and van Vliet-Ostaptchouk, JV and Vohl, M and V�lker, U and Waeber, G and Walker, M and Wild, S and Wong, A and Wright, AF and Zillikens, MC and Zubair, N and Haiman, CA and Lemarchand, L and Gyllensten, U and Ohlsson, C and Hofman, A and Rivadeneira, F and Uitterlinden, AG and P�russe, L and Wilson, JF and Hayward, C and Polasek, O and Cucca, F and Hveem, K and Hartman, CA and T�njes, A and Bandinelli, S and Palmer, LJ and Kardia, SLR and Rauramaa, R and S�rensen, TIA and Tuomilehto, J and Salomaa, V and Penninx, BWJH and de Geus, EJC and Boomsma, DI and Lehtim�ki, T and Mangino, M and Laakso, M and Bouchard, C and Martin, NG and Kuh, D and Liu, Y and Linneberg, A and M�rz, W and Strauch, K and Kivim�ki, M and Harris, TB and Gudnason, V and V�lzke, H and Qi, L and J�rvelin, M and Chambers, JC and Kooner, JS and Froguel, P and Kooperberg, C and Vollenweider, P and Hallmans, G and Hansen, T and Pedersen, O and Metspalu, A and Wareham, NJ and Langenberg, C and Weir, DR and Porteous, DJ and Boerwinkle, E and Chasman, DI and Abecasis, GR and Barroso, I and McCarthy, MI and Frayling, TM and O?Connell, JR and van Duijn, CM and Boehnke, M and Heid, IM and Mohlke, KL and Strachan, DP and Fox, CS and Liu, C and Hirschhorn, JN and Klein, RJ and Johnson, AD and Borecki, IB and Franks, PW and North, KE and Cupples, LA and Loos, RJF and Kilpel�inen, TO (2017) Genome-wide physical activity interactions in adiposity ? A meta-analysis of 200,452 adults. PLoS Genetics, 13 (4). creators-Kumari=3AMeena=3A=3A. DOI https://doi.org/10.1371/journal.pgen.1006528
Graff, M and Scott, RA and Justice, AE and Young, KL and Feitosa, MF and Winkler, TW and Barata, L and Chu, AY and Mahajan, A and Hadley, D and Xue, L and Workalemahu, T and Heard-Costa, NL and den Hoed, M and Ahluwalia, TS and Qi, Q and Ngwa, JS and Renstr�m, F and Quaye, L and Eicher, JD and Hayes, JE and Cornelis, M and Kutalik, Z and Lim, E and Luan, J and Huffman, JE and Zhang, W and Zhao, W and Griffin, PJ and Haller, T and Ahmad, S and Marques-Vidal, PM and Bien, S and Yengo, L and Teumer, A and Smith, AV and Kumari, M and Harder, MN and Justesen, JM and Kleber, ME and Hollensted, M and Lohman, K and Rivera, NV and Whitfield, JB and Zhao, JH and Stringham, HM and Lyytik�inen, L and Huppertz, C and Willemsen, G and Peyrot, WJ and Wu, Y and Kristiansson, K and Demirkan, A and Fornage, M and Hassinen, M and Bielak, LF and Cadby, G and Tanaka, T and M�gi, R and van der Most, PJ and Jackson, AU and Bragg-Gresham, JL and Vitart, V and Marten, J and Navarro, P and Bellis, C and Pasko, D and Johansson and Snitker, S and Cheng, Y and Eriksson, J and Lim, U and Aadahl, M and Adair, LS and Amin, N and Balkau, B and Auvinen, J and Beilby, J and Bergman, RN and Bergmann, S and Bertoni, AG and Blangero, J and Bonnefond, A and Bonnycastle, LL and Borja, JB and Brage, S and Busonero, F and Buyske, S and Campbell, H and Chines, PS and Collins, FS and Corre, T and Smith, GD and Delgado, GE and Dueker, N and D�rr, M and Ebeling, T and Eiriksdottir, G and Esko, T and Faul, JD and Fu, M and F�rch, K and Gieger, C and Gl�ser, S and Gong, J and Gordon-Larsen, P and Grallert, H and Grammer, TB and Grarup, N and van Grootheest, G and Harald, K and Hastie, ND and Havulinna, AS and Hernandez, D and Hindorff, L and Hocking, LJ and Holmens, OL and Holzapfel, C and Hottenga, JJ and Huang, J and Huang, T and Hui, J and Huth, C and Hutri-K�h�nen, N and James, AL and Jansson, J and Jhun, MA and Juonala, M and Kinnunen, L and Koistinen, HA and Kolcic, I and Komulainen, P and Kuusisto, J and Kval�y, K and K�h�nen, M and Lakka, TA and Launer, LJ and Lehne, B and Lindgren, CM and Lorentzon, M and Luben, R and Marre, M and Milaneschi, Y and Monda, KL and Montgomery, GW and De Moor, MHM and Mulas, A and M�ller-Nurasyid, M and Musk, AW and M�nnikk�, R and M�nnist�, S and Narisu, N and Nauck, M and Nettleton, JA and Nolte, IM and Oldehinkel, AJ and Olden, M and Ong, KK and Padmanabhan, S and Paternoster, L and Perez, J and Perola, M and Peters, A and Peters, U and Peyser, PA and Prokopenko, I and Puolijoki, H and Raitakari, OT and Rankinen, T and Rasmussen-Torvik, LJ and Rawal, R and Ridker, PM and Rose, LM and Rudan, I and Sarti, C and Sarzynski, MA and Savonen, K and Scott, WR and Sanna, S and Shuldiner, AR and Sidney, S and Silbernagel, G and Smith, BH and Smith, JA and Snieder, H and Stan?�kov�, A and Sternfeld, B and Swift, AJ and Tammelin, T and Tan, S and Thorand, B and Thuillier, D and Vandenput, L and Vestergaard, H and van Vliet-Ostaptchouk, JV and Vohl, M and V�lker, U and Waeber, G and Walker, M and Wild, S and Wong, A and Wright, AF and Zillikens, MC and Zubair, N and Haiman, CA and Lemarchand, L and Gyllensten, U and Ohlsson, C and Hofman, A and Rivadeneira, F and Uitterlinden, AG and P�russe, L and Wilson, JF and Hayward, C and Polasek, O and Cucca, F and Hveem, K and Hartman, CA and T�njes, A and Bandinelli, S and Palmer, LJ and Kardia, SLR and Rauramaa, R and S�rensen, TIA and Tuomilehto, J and Salomaa, V and Penninx, BWJH and de Geus, EJC and Boomsma, DI and Lehtim�ki, T and Mangino, M and Laakso, M and Bouchard, C and Martin, NG and Kuh, D and Liu, Y and Linneberg, A and M�rz, W and Strauch, K and Kivim�ki, M and Harris, TB and Gudnason, V and V�lzke, H and Qi, L and J�rvelin, M and Chambers, JC and Kooner, JS and Froguel, P and Kooperberg, C and Vollenweider, P and Hallmans, G and Hansen, T and Pedersen, O and Metspalu, A and Wareham, NJ and Langenberg, C and Weir, DR and Porteous, DJ and Boerwinkle, E and Chasman, DI and Abecasis, GR and Barroso, I and McCarthy, MI and Frayling, TM and O?Connell, JR and van Duijn, CM and Boehnke, M and Heid, IM and Mohlke, KL and Strachan, DP and Fox, CS and Liu, C and Hirschhorn, JN and Klein, RJ and Johnson, AD and Borecki, IB and Franks, PW and North, KE and Cupples, LA and Loos, RJF and Kilpel�inen, TO (2017) Genome-wide physical activity interactions in adiposity ? A meta-analysis of 200,452 adults. PLoS Genetics, 13 (4). creators-Kumari=3AMeena=3A=3A. DOI https://doi.org/10.1371/journal.pgen.1006528
Abstract
Physical activity (PA) may modify the genetic effects that give rise to increased risk of obesity. To identify adiposity loci whose effects are modified by PA, we performed genome-wide interaction meta-analyses of BMI and BMI-adjusted waist circumference and waist-hip ratio from up to 200,452 adults of European (n = 180,423) or other ancestry (n = 20,029). We standardized PA by categorizing it into a dichotomous variable where, on average, 23% of participants were categorized as inactive and 77% as physically active. While we replicate the interaction with PA for the strongest known obesity-risk locus in the FTO gene, of which the effect is attenuated by ~30% in physically active individuals compared to inactive individuals, we do not identify additional loci that are sensitive to PA. In additional genome-wide meta-analyses adjusting for PA and interaction with PA, we identify 11 novel adiposity loci, suggesting that accounting for PA or other environmental factors that contribute to variation in adiposity may facilitate gene discovery.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CHARGE Consortium; EPIC-InterAct Consortium; PAGE Consortium; Humans; Obesity; Genetic Predisposition to Disease; Body Mass Index; Waist-Hip Ratio; Exercise; Genotype; Female; Male; Adiposity; Waist Circumference; Genome-Wide Association Study; Epigenomics; Alpha-Ketoglutarate-Dependent Dioxygenase FTO |
| Subjects: | H Social Sciences > H Social Sciences (General) R Medicine > R Medicine (General) |
| Divisions: | Faculty of Social Sciences Faculty of Social Sciences > Institute for Social and Economic Research |
| SWORD Depositor: | Unnamed user with email elements@essex.ac.uk |
| Depositing User: | Unnamed user with email elements@essex.ac.uk |
| Date Deposited: | 22 Jun 2017 15:49 |
| Last Modified: | 04 Dec 2024 06:23 |
| URI: | http://repository.essex.ac.uk/id/eprint/19918 |
Available files
Filename: journal.pgen.1006528.pdf
Licence: Creative Commons: Attribution 3.0