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Genome-wide analysis identifies 12 loci influencing human reproductive behavior

Barban, Nicola and Jansen, Rick and de Vlaming, Ronald and Vaez, Ahmad and Mandemakers, Jornt J and Tropf, Felix C and Shen, Xia and Wilson, James F and Chasman, Daniel I and Nolte, Ilja M and Tragante, Vinicius and van der Laan, Sander W and Perry, John RB and Kong, Augustine and Ahluwalia, Tarunveer S and Albrecht, Eva and Yerges-Armstrong, Laura and Atzmon, Gil and Auro, Kirsi and Ayers, Kristin and Bakshi, Andrew and Ben-Avraham, Danny and Berger, Klaus and Bergman, Aviv and Bertram, Lars and Bielak, Lawrence F and Bjornsdottir, Gyda and Bonder, Marc Jan and Broer, Linda and Bui, Minh and Barbieri, Caterina and Cavadino, Alana and Chavarro, Jorge E and Turman, Constance and Concas, Maria Pina and Cordell, Heather J and Davies, Gail and Eibich, Peter and Eriksson, Nicholas and Esko, Tõnu and Eriksson, Joel and Falahi, Fahimeh and Felix, Janine F and Fontana, Mark Alan and Franke, Lude and Gandin, Ilaria and Gaskins, Audrey J and Gieger, Christian and Gunderson, Erica P and Guo, Xiuqing and Hayward, Caroline and He, Chunyan and Hofer, Edith and Huang, Hongyan and Joshi, Peter K and Kanoni, Stavroula and Karlsson, Robert and Kiechl, Stefan and Kifley, Annette and Kluttig, Alexander and Kraft, Peter and Lagou, Vasiliki and Lecoeur, Cecile and Lahti, Jari and Li-Gao, Ruifang and Lind, Penelope A and Liu, Tian and Makalic, Enes and Mamasoula, Crysovalanto and Matteson, Lindsay and Mbarek, Hamdi and McArdle, Patrick F and McMahon, George and Meddens, S Fleur W and Mihailov, Evelin and Miller, Mike and Missmer, Stacey A and Monnereau, Claire and van der Most, Peter J and Myhre, Ronny and Nalls, Mike A and Nutile, Teresa and Kalafati, Ioanna Panagiota and Porcu, Eleonora and Prokopenko, Inga and Rajan, Kumar B and Rich-Edwards, Janet and Rietveld, Cornelius A and Robino, Antonietta and Rose, Lynda M and Rueedi, Rico and Ryan, Kathleen A and Saba, Yasaman and Schmidt, Daniel and Smith, Jennifer A and Stolk, Lisette and Streeten, Elizabeth and Tönjes, Anke and Thorleifsson, Gudmar and Ulivi, Sheila and Wedenoja, Juho and Wellmann, Juergen and Willeit, Peter and Yao, Jie and Yengo, Loic and Zhao, Jing Hua and Zhao, Wei and Zhernakova, Daria V and Amin, Najaf and Andrews, Howard and Balkau, Beverley and Barzilai, Nir and Bergmann, Sven and Biino, Ginevra and Bisgaard, Hans and Bønnelykke, Klaus and Boomsma, Dorret I and Buring, Julie E and Campbell, Harry and Cappellani, Stefania and Ciullo, Marina and Cox, Simon R and Cucca, Francesco and Toniolo, Daniela and Davey-Smith, George and Deary, Ian J and Dedoussis, George and Deloukas, Panos and van Duijn, Cornelia M and de Geus, Eco JC and Eriksson, Johan G and Evans, Denis A and Faul, Jessica D and Sala, Cinzia Felicita and Froguel, Philippe and Gasparini, Paolo and Girotto, Giorgia and Grabe, Hans-Jörgen and Greiser, Karin Halina and Groenen, Patrick JF and de Haan, Hugoline G and Haerting, Johannes and Harris, Tamara B and Heath, Andrew C and Heikkilä, Kauko and Hofman, Albert and Homuth, Georg and Holliday, Elizabeth G and Hopper, John and Hyppönen, Elina and Jacobsson, Bo and Jaddoe, Vincent WV and Johannesson, Magnus and Jugessur, Astanand and Kähönen, Mika and Kajantie, Eero and Kardia, Sharon LR and Keavney, Bernard and Kolcic, Ivana and Koponen, Päivikki and Kovacs, Peter and Kronenberg, Florian and Kutalik, Zoltan and La Bianca, Martina and Lachance, Genevieve and Iacono, William G and Lai, Sandra and Lehtimäki, Terho and Liewald, David C and Lindgren, Cecilia M and Liu, Yongmei and Luben, Robert and Lucht, Michael and Luoto, Riitta and Magnus, Per and Magnusson, Patrik KE and Martin, Nicholas G and McGue, Matt and McQuillan, Ruth and Medland, Sarah E and Meisinger, Christa and Mellström, Dan and Metspalu, Andres and Traglia, Michela and Milani, Lili and Mitchell, Paul and Montgomery, Grant W and Mook-Kanamori, Dennis and de Mutsert, Renée and Nohr, Ellen A and Ohlsson, Claes and Olsen, Jørn and Ong, Ken K and Paternoster, Lavinia and Pattie, Alison and Penninx, Brenda WJH and Perola, Markus and Peyser, Patricia A and Pirastu, Mario and Polasek, Ozren and Power, Chris and Kaprio, Jaakko and Raffel, Leslie J and Räikkönen, Katri and Raitakari, Olli and Ridker, Paul M and Ring, Susan M and Roll, Kathryn and Rudan, Igor and Ruggiero, Daniela and Rujescu, Dan and Salomaa, Veikko and Schlessinger, David and Schmidt, Helena and Schmidt, Reinhold and Schupf, Nicole and Smit, Johannes and Sorice, Rossella and Spector, Tim D and Starr, John M and Stöckl, Doris and Strauch, Konstantin and Stumvoll, Michael and Swertz, Morris A and Thorsteinsdottir, Unnur and Thurik, A Roy and Timpson, Nicholas J and Tung, Joyce Y and Uitterlinden, André G and Vaccargiu, Simona and Viikari, Jorma and Vitart, Veronique and Völzke, Henry and Vollenweider, Peter and Vuckovic, Dragana and Waage, Johannes and Wagner, Gert G and Wang, Jie Jin and Wareham, Nicholas J and Weir, David R and Willemsen, Gonneke and Willeit, Johann and Wright, Alan F and Zondervan, Krina T and Stefansson, Kari and Krueger, Robert F and Lee, James J and Benjamin, Daniel J and Cesarini, David and Koellinger, Philipp D and den Hoed, Marcel and Snieder, Harold and Mills, Melinda C (2016) 'Genome-wide analysis identifies 12 loci influencing human reproductive behavior.' Nature Genetics, 48 (12). 1462 - 1472. ISSN 1061-4036

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Abstract

The genetic architecture of human reproductive behavior—age at first birth (AFB) and number of children ever born (NEB)—has a strong relationship with fitness, human development, infertility and risk of neuropsychiatric disorders. However, very few genetic loci have been identified, and the underlying mechanisms of AFB and NEB are poorly understood. We report a large genome-wide association study of both sexes including 251,151 individuals for AFB and 343,072 individuals for NEB. We identified 12 independent loci that are significantly associated with AFB and/or NEB in a SNP-based genome-wide association study and 4 additional loci associated in a gene-based effort. These loci harbor genes that are likely to have a role, either directly or by affecting non-local gene expression, in human reproduction and infertility, thereby increasing understanding of these complex traits.

Item Type: Article
Subjects: H Social Sciences > H Social Sciences (General)
Q Science > QH Natural history > QH426 Genetics
Divisions: Faculty of Social Sciences > Institute for Social and Economic Research
Depositing User: Elements
Date Deposited: 06 Sep 2018 09:14
Last Modified: 06 Sep 2018 09:14
URI: http://repository.essex.ac.uk/id/eprint/22119

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