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Socioeconomic Position and DNA Methylation Age Acceleration across the Lifecourse.

Hughes, Amanda and Smart, Melissa and Gorrie-Stone, Tyler and Hannon, Eilis and Mill, Jonathan and Bao, Yanchun and Burrage, Joe and Schalkwyk, Leo and Kumari, Meena (2018) 'Socioeconomic Position and DNA Methylation Age Acceleration across the Lifecourse.' American Journal of Epidemiology, 187 (11). pp. 2346-2354. ISSN 0002-9262

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Accelerated DNA methylation age is linked to all-cause mortality and environmental factors, but studies of associations with socioeconomic position are limited. Studies generally use small selected samples, and it is unclear how findings with two commonly used methylation age calculations (Horvath and Hannum) translate to general population samples including younger and older adults. In 1099 UK adults aged 28-98 y in 2011-12, we assessed the relationship of Horvath and Hannum DNA methylation age acceleration with a range of social position measures: current income and employment, education, income and unemployment across a 12-year period, and childhood social class. Accounting for confounders, participants less advantaged in childhood were epigenetically 'older' as adults: compared to participants with professional/managerial parents, Hannum age was 1.07 years higher (95% confidence interval (CI):0.20-1.94) for those with parents in semi-skilled/unskilled occupations, and 1.85 years higher (95%CI:0.67-3.02) for participants without a working parent at age 14. No other robust associations were seen. Results accord with research implicating early life circumstances as critical for DNA methylation age in adulthood. Since methylation age acceleration as measured by the Horvath and Hannum estimators appears strongly linked to chronological age, research examining associations with the social environment must take steps to avoid age-related confounding.

Item Type: Article
Uncontrolled Keywords: aging, epigenomics, socioeconomic factors
Subjects: H Social Sciences > H Social Sciences (General)
Q Science > QH Natural history > QH426 Genetics
Divisions: Faculty of Science and Health
Faculty of Science and Health > Mathematical Sciences, Department of
Faculty of Social Sciences
Faculty of Social Sciences > Institute for Social and Economic Research
Faculty of Science and Health > Life Sciences, School of
SWORD Depositor: Elements
Depositing User: Elements
Date Deposited: 10 Aug 2018 11:55
Last Modified: 06 Jan 2022 13:52

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