Skaaby, Tea and Taylor, Amy E and Jacobsen, Rikke K and Paternoster, Lavinia and Thuesen, Betina H and Ahluwalia, Tarunveer S and Larsen, Sofus C and Zhou, Ang and Wong, Andrew and Gabrielsen, Maiken E and Bjørngaard, Johan H and Flexeder, Claudia and Männistö, Satu and Hardy, Rebecca and Kuh, Diana and Barry, Sarah J and Tang Møllehave, Line and Cerqueira, Charlotte and Friedrich, Nele and Bonten, Tobias N and Noordam, Raymond and Mook-Kanamori, Dennis O and Taube, Christian and Jessen, Leon E and McConnachie, Alex and Sattar, Naveed and Upton, Mark N and McSharry, Charles and Bønnelykke, Klaus and Bisgaard, Hans and Schulz, Holger and Strauch, Konstantin and Meitinger, Thomas and Peters, Annette and Grallert, Harald and Nohr, Ellen A and Kivimaki, Mika and Kumari, Meena and Völker, Uwe and Nauck, Matthias and Völzke, Henry and Power, Chris and Hyppönen, Elina and Hansen, Torben and Jørgensen, Torben and Pedersen, Oluf and Salomaa, Veikko and Grarup, Niels and Langhammer, Arnulf and Romundstad, Pål R and Skorpen, Frank and Kaprio, Jaakko and R Munafò, Marcus and Linneberg, Allan (2017) Investigating the causal effect of smoking on hay fever and asthma: a Mendelian randomization meta-analysis in the CARTA consortium. Scientific Reports, 7 (1). 2224-. DOI https://doi.org/10.1038/s41598-017-01977-w
Skaaby, Tea and Taylor, Amy E and Jacobsen, Rikke K and Paternoster, Lavinia and Thuesen, Betina H and Ahluwalia, Tarunveer S and Larsen, Sofus C and Zhou, Ang and Wong, Andrew and Gabrielsen, Maiken E and Bjørngaard, Johan H and Flexeder, Claudia and Männistö, Satu and Hardy, Rebecca and Kuh, Diana and Barry, Sarah J and Tang Møllehave, Line and Cerqueira, Charlotte and Friedrich, Nele and Bonten, Tobias N and Noordam, Raymond and Mook-Kanamori, Dennis O and Taube, Christian and Jessen, Leon E and McConnachie, Alex and Sattar, Naveed and Upton, Mark N and McSharry, Charles and Bønnelykke, Klaus and Bisgaard, Hans and Schulz, Holger and Strauch, Konstantin and Meitinger, Thomas and Peters, Annette and Grallert, Harald and Nohr, Ellen A and Kivimaki, Mika and Kumari, Meena and Völker, Uwe and Nauck, Matthias and Völzke, Henry and Power, Chris and Hyppönen, Elina and Hansen, Torben and Jørgensen, Torben and Pedersen, Oluf and Salomaa, Veikko and Grarup, Niels and Langhammer, Arnulf and Romundstad, Pål R and Skorpen, Frank and Kaprio, Jaakko and R Munafò, Marcus and Linneberg, Allan (2017) Investigating the causal effect of smoking on hay fever and asthma: a Mendelian randomization meta-analysis in the CARTA consortium. Scientific Reports, 7 (1). 2224-. DOI https://doi.org/10.1038/s41598-017-01977-w
Skaaby, Tea and Taylor, Amy E and Jacobsen, Rikke K and Paternoster, Lavinia and Thuesen, Betina H and Ahluwalia, Tarunveer S and Larsen, Sofus C and Zhou, Ang and Wong, Andrew and Gabrielsen, Maiken E and Bjørngaard, Johan H and Flexeder, Claudia and Männistö, Satu and Hardy, Rebecca and Kuh, Diana and Barry, Sarah J and Tang Møllehave, Line and Cerqueira, Charlotte and Friedrich, Nele and Bonten, Tobias N and Noordam, Raymond and Mook-Kanamori, Dennis O and Taube, Christian and Jessen, Leon E and McConnachie, Alex and Sattar, Naveed and Upton, Mark N and McSharry, Charles and Bønnelykke, Klaus and Bisgaard, Hans and Schulz, Holger and Strauch, Konstantin and Meitinger, Thomas and Peters, Annette and Grallert, Harald and Nohr, Ellen A and Kivimaki, Mika and Kumari, Meena and Völker, Uwe and Nauck, Matthias and Völzke, Henry and Power, Chris and Hyppönen, Elina and Hansen, Torben and Jørgensen, Torben and Pedersen, Oluf and Salomaa, Veikko and Grarup, Niels and Langhammer, Arnulf and Romundstad, Pål R and Skorpen, Frank and Kaprio, Jaakko and R Munafò, Marcus and Linneberg, Allan (2017) Investigating the causal effect of smoking on hay fever and asthma: a Mendelian randomization meta-analysis in the CARTA consortium. Scientific Reports, 7 (1). 2224-. DOI https://doi.org/10.1038/s41598-017-01977-w
Abstract
<jats:title>Abstract</jats:title><jats:p>Observational studies on smoking and risk of hay fever and asthma have shown inconsistent results. However, observational studies may be biased by confounding and reverse causation. Mendelian randomization uses genetic variants as markers of exposures to examine causal effects. We examined the causal effect of smoking on hay fever and asthma by using the smoking-associated single nucleotide polymorphism (SNP) rs16969968/rs1051730. We included 231,020 participants from 22 population-based studies. Observational analyses showed that current vs never smokers had lower risk of hay fever (odds ratio (OR) = 0·68, 95% confidence interval (CI): 0·61, 0·76; P < 0·001) and allergic sensitization (OR = 0·74, 95% CI: 0·64, 0·86; P < 0·001), but similar asthma risk (OR = 1·00, 95% CI: 0·91, 1·09; P = 0·967). Mendelian randomization analyses in current smokers showed a slightly lower risk of hay fever (OR = 0·958, 95% CI: 0·920, 0·998; P = 0·041), a lower risk of allergic sensitization (OR = 0·92, 95% CI: 0·84, 1·02; P = 0·117), but higher risk of asthma (OR = 1·06, 95% CI: 1·01, 1·11; P = 0·020) per smoking-increasing allele. Our results suggest that smoking may be causally related to a higher risk of asthma and a slightly lower risk of hay fever. However, the adverse events associated with smoking limit its clinical significance.</jats:p>
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Humans; Asthma; Disease Susceptibility; Genetic Predisposition to Disease; Odds Ratio; Smoking; Genotype; Alleles; Adolescent; Adult; Middle Aged; Rhinitis, Allergic, Seasonal; Young Adult; Mendelian Randomization Analysis |
| Subjects: | H Social Sciences > H Social Sciences (General) R Medicine > R Medicine (General) |
| Divisions: | Faculty of Social Sciences Faculty of Social Sciences > Institute for Social and Economic Research |
| SWORD Depositor: | Unnamed user with email elements@essex.ac.uk |
| Depositing User: | Unnamed user with email elements@essex.ac.uk |
| Date Deposited: | 22 Jun 2017 15:54 |
| Last Modified: | 04 Dec 2024 07:14 |
| URI: | http://repository.essex.ac.uk/id/eprint/19937 |
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