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Items where Author is "Reynolds, Christopher A"

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Article

Deganutti, Giuseppe and Prischi, Filippo and Reynolds, Christopher A (2021) 'Supervised molecular dynamics for exploring the druggability of the SARS-CoV-2 spike protein.' Journal of Computer-Aided Molecular Design, 35 (2). pp. 195-207. ISSN 0920-654X

Dong, Maoqing and Deganutti, Giuseppe and Piper, Sarah J and Liang, Yi-Lynn and Khoshouei, Maryam and Belousoff, Matthew J and Harikumar, Kaleeckal G and Reynolds, Christopher A and Glukhova, Alisa and Furness, Sebastian GB and Christopoulos, Arthur and Danev, Radostin and Wootten, Denise and Sexton, Patrick M and Miller, Laurence J (2020) 'Structure and dynamics of the active Gs-coupled human secretin receptor.' Nature Communications, 11 (1). 4137-. ISSN 2041-1723

Deganutti, Giuseppe and Moro, Stefano and Reynolds, Christopher A (2020) 'A Supervised Molecular Dynamics Approach to Unbiased Ligand–Protein Unbinding.' Journal of Chemical Information and Modeling, 60 (3). pp. 1804-1817. ISSN 1549-9596

Zhao, Peishen and Liang, Yi-Lynn and Belousoff, Matthew J and Deganutti, Giuseppe and Fletcher, Madeleine M and Willard, Francis S and Bell, Michael G and Christe, Michael E and Sloop, Kyle W and Inoue, Asuka and Truong, Tin T and Clydesdale, Lachlan and Furness, Sebastian GB and Christopoulos, Arthur and Wang, Ming-Wei and Miller, Laurence J and Reynolds, Christopher A and Danev, Radostin and Sexton, Patrick M and Wootten, Denise (2020) 'Activation of the GLP-1 receptor by a non-peptidic agonist.' Nature, 577 (7790). pp. 432-436. ISSN 0028-0836

Pham, Vi and Zhu, Yue and Dal Maso, Emma and Reynolds, Christopher A and Deganutti, Giuseppe and Atanasio, Silvia and Hick, Caroline A and Yang, Dehua and Christopoulos, Arthur and Hay, Debbie L and Furness, Sebastian GB and Wang, Ming-Wei and Wootten, Denise and Sexton, Patrick M (2019) 'Deconvoluting the Molecular Control of Binding and Signaling at the Amylin 3 Receptor: RAMP3 Alters Signal Propagation through Extracellular Loops of the Calcitonin Receptor.' ACS Pharmacology and Translational Science, 2 (3). pp. 183-197. ISSN 2575-9108

Deganutti, Giuseppe and Moro, Stefano and Reynolds, Christopher A (2019) 'Peeking at G-protein-coupled receptors through the molecular dynamics keyhole.' Future Medicinal Chemistry, 11 (6). pp. 599-615. ISSN 1756-8919

dal Maso, Emma and Glukhova, Alisa and Zhu, Yue and Garcia-Nafria, Javier and Tate, Christopher G and Atanasio, Silvia and Reynolds, Christopher A and Ramírez-Aportela, Erney and Carazo, Jose-Maria and Hick, Caroline A and Furness, Sebastian GB and Hay, Debbie L and Liang, Yi-Lynn and Miller, Laurence J and Christopoulos, Arthur and Wang, Ming-Wei and Wootten, Denise and Sexton, Patrick M (2019) 'The Molecular Control of Calcitonin Receptor Signaling.' ACS Pharmacology & Translational Science, 2 (1). pp. 31-51. ISSN 2575-9108

Liang, Yi-Lynn and Khoshouei, Maryam and Deganutti, Giuseppe and Glukhova, Alisa and Koole, Cassandra and Peat, Thomas S and Radjainia, Mazdak and Plitzko, Jürgen M and Baumeister, Wolfgang and Miller, Laurence J and Hay, Deborah L and Christopoulos, Arthur and Reynolds, Christopher A and Wootten, Denise and Sexton, Patrick M (2018) 'Cryo-EM structure of the active, Gs-protein complexed, human CGRP receptor.' Nature, 561 (7724). pp. 492-497. ISSN 0028-0836

Simms, John and Uddin, Romez and Sakmar, Thomas P and Gingell, Joseph J and Garelja, Michael L and Hay, Debbie L and Brimble, Margaret A and Harris, Paul WR and Reynolds, Christopher A and Poyner, David R (2018) 'Photoaffinity cross-linking and unnatural amino acid mutagenesis reveal insights into calcitonin gene-related peptide binding to the calcitonin receptor-like receptor/receptor activity-modifying protein 1 (CLR/RAMP1) complex.' Biochemistry, 57 (32). pp. 4915-4922. ISSN 0006-2960

Dal Maso, Emma and Zhu, Yue and Pham, Vi and Reynolds, Christopher A and Deganutti, Giuseppe and Hick, Caroline A and Yang, Dehua and Christopoulos, Arthur and Hay, Debbie L and Wang, Ming-Wei and Sexton, Patrick M and Furness, Sebastian GB and Wootten, Denise (2018) 'Extracellular loops 2 and 3 of the calcitonin receptor selectively modify agonist binding and efficacy.' Biochemical Pharmacology, 150. pp. 214-244. ISSN 0006-2952

Woolley, Michael J and Reynolds, Christopher A and Simms, John and Walker, Christopher S and Mobarec, Juan Carlos and Garelja, Michael L and Conner, Alex C and Poyner, David R and Hay, Debbie L (2017) 'Receptor activity-modifying protein dependent and independent activation mechanisms in the coupling of calcitonin gene-related peptide and adrenomedullin receptors to Gs.' Biochemical Pharmacology, 142. pp. 96-110. ISSN 0006-2952

Woolley, Michael J and Simms, John and Mobarec, Juan Carlos and Reynolds, Christopher A and Poyner, David R and Conner, Alex C (2017) 'Understanding the molecular functions of the second extracellular loop (ECL2) of the calcitonin gene-related peptide (CGRP) receptor using a comprehensive mutagenesis approach.' Molecular and Cellular Endocrinology, 454 (C). pp. 39-49. ISSN 0303-7207

Koole, Cassandra and Reynolds, Christopher A and Mobarec, Juan C and Hick, Caroline and Sexton, Patrick M and Sakmar, Thomas P (2017) 'Genetically encoded photocross-linkers determine the biological binding site of exendin-4 peptide in the N-terminal domain of the intact human glucagon-like peptide-1 receptor (GLP-1R).' Journal of Biological Chemistry, 292 (17). pp. 7131-7144. ISSN 0021-9258

Weaver, Richard E and Mobarec, Juan C and Wigglesworth, Mark J and Reynolds, Christopher A and Donnelly, Dan (2017) 'High affinity binding of the peptide agonist TIP-39 to the parathyroid hormone 2 (PTH 2 ) receptor requires the hydroxyl group of Tyr-318 on transmembrane helix 5.' Biochemical Pharmacology, 127. pp. 71-81. ISSN 0006-2952

Weston, Cathryn and Winfield, Ian and Harris, Matthew and Hodgson, Rose and Shah, Archna and Dowell, Simon J and Mobarec, Juan Carlos and Woodlock, David A and Reynolds, Christopher A and Poyner, David R and Watkins, Harriet A and Ladds, Graham (2016) 'Receptor Activity-modifying Protein-directed G Protein Signaling Specificity for the Calcitonin Gene-related Peptide Family of Receptors.' Journal of Biological Chemistry, 291 (42). pp. 21925-21944. ISSN 0021-9258

Wootten, Denise and Reynolds, Christopher A and Smith, Kevin J and Mobarec, Juan C and Furness, Sebastian GB and Miller, Laurence J and Christopoulos, Arthur and Sexton, Patrick M (2016) 'Key interactions by conserved polar amino acids located at the transmembrane helical boundaries in Class B GPCRs modulate activation, effector specificity and biased signalling in the glucagon-like peptide-1 receptor.' Biochemical Pharmacology, 118. pp. 68-87. ISSN 0006-2952

Wootten, Denise and Reynolds, Christopher A and Smith, Kevin J and Mobarec, Juan C and Koole, Cassandra and Savage, Emilia E and Pabreja, Kavita and Simms, John and Sridhar, Rohan and Furness, Sebastian GB and Liu, Mengjie and Thompson, Philip E and Miller, Laurence J and Christopoulos, Arthur and Sexton, Patrick M (2016) 'The Extracellular Surface of the GLP-1 Receptor Is a Molecular Trigger for Biased Agonism.' Cell, 165 (7). pp. 1632-1643. ISSN 0092-8674

Watkins, Harriet A and Chakravarthy, Madhuri and Abhayawardana, Rekhati S and Gingell, Joseph J and Garelja, Michael and Pardamwar, Meenakshi and McElhinney, James MWR and Lathbridge, Alex and Constantine, Arran and Harris, Paul WR and Yuen, Tsz-Ying and Brimble, Margaret A and Barwell, James and Poyner, David R and Woolley, Michael J and Conner, Alex C and Pioszak, Augen A and Reynolds, Christopher A and Hay, Debbie L (2016) 'Receptor Activity-modifying Proteins 2 and 3 Generate Adrenomedullin Receptor Subtypes with Distinct Molecular Properties.' Journal of Biological Chemistry, 291 (22). pp. 11657-11675. ISSN 0021-9258

Hay, Debbie L and Walker, Christopher S and Gingell, Joseph J and Ladds, Graham and Reynolds, Christopher A and Poyner, David R (2016) 'Receptor activity-modifying proteins; multifunctional G protein-coupled receptor accessory proteins.' Biochemical Society Transactions, 44 (2). pp. 568-573. ISSN 0300-5127

Wootten, Denise and Reynolds, Christopher A and Koole, Cassandra and Smith, Kevin J and Mobarec, Juan C and Simms, John and Quon, Tezz and Coudrat, Thomas and Furness, Sebastian GB and Miller, Laurence J and Christopoulos, Arthur and Sexton, Patrick M (2016) 'A Hydrogen-Bonded Polar Network in the Core of the Glucagon-Like Peptide-1 Receptor Is a Fulcrum for Biased Agonism: Lessons from Class B Crystal Structures.' Molecular Pharmacology, 89 (3). pp. 335-347. ISSN 0026-895X

Weston, Cathryn and Lu, Jing and Li, Naichang and Barkan, Kerry and Richards, Gareth O and Roberts, David J and Skerry, Timothy M and Poyner, David and Pardamwar, Meenakshi and Reynolds, Christopher A and Dowell, Simon J and Willars, Gary B and Ladds, Graham (2015) 'Modulation of Glucagon Receptor Pharmacology by Receptor Activity-modifying Protein-2 (RAMP2).' Journal of Biological Chemistry, 290 (38). pp. 23009-23022. ISSN 0021-9258

Lock, Antonia and Forfar, Rachel and Weston, Cathryn and Bowsher, Leo and Upton, Graham JG and Reynolds, Christopher A and Ladds, Graham and Dixon, Ann M (2014) 'One motif to bind them: A small-XXX-small motif affects transmembrane domain 1 oligomerization, function, localization, and cross-talk between two yeast GPCRs.' Biochimica et Biophysica Acta (BBA) - Biomembranes, 1838 (12). pp. 3036-3051. ISSN 0005-2736

Roy, Aparna and Taddese, Bruck and Vohra, Shabana and Thimmaraju, Phani K and Illingworth, Christopher JR and Simpson, Lisa M and Mukherjee, Keya and Reynolds, Christopher A and Chintapalli, Sree V (2014) 'Identifying subset errors in multiple sequence alignments.' Journal of Biomolecular Structure and Dynamics, 32 (3). pp. 364-371. ISSN 0739-1102

Chintapalli, Sree V and Illingworth, Christopher JR and Upton, Graham JG and Sacquin-Mora, Sophie and Reeves, Philip J and Mohammedali, Hani S and Reynolds, Christopher A (2014) 'Assessing the effect of dynamics on the closed-loop protein-folding hypothesis.' Journal of The Royal Society Interface, 11 (91). p. 20130935. ISSN 1742-5689

Woolley, Michael J and Watkins, Harriet A and Taddese, Bruck and Karakullukcu, Z Gamze and Barwell, James and Smith, Kevin J and Hay, Debbie L and Poyner, David R and Reynolds, Christopher A and Conner, Alex C (2013) 'The role of ECL2 in CGRP receptor activation: a combined modelling and experimental approach.' Journal of The Royal Society Interface, 10 (88). p. 20130589. ISSN 1742-5689

Opefi, Chikwado A and South, Kieron and Reynolds, Christopher A and Smith, Steven O and Reeves, Philip J (2013) 'Retinitis Pigmentosa Mutants Provide Insight into the Role of the N-terminal Cap in Rhodopsin Folding, Structure, and Function.' Journal of Biological Chemistry, 288 (47). pp. 33912-33926. ISSN 0021-9258

Vohra, Shabana and Taddese, Bruck and Conner, Alex C and Poyner, David R and Hay, Debbie L and Barwell, James and Reeves, Philip J and Upton, Graham JG and Reynolds, Christopher A (2013) 'Similarity between class A and class B G-protein-coupled receptors exemplified through calcitonin gene-related peptide receptor modelling and mutagenesis studies.' Journal of The Royal Society Interface, 10 (79). p. 20120846. ISSN 1742-5689

Barwell, James and Wheatley, Mark and Conner, Alex C and Taddese, Bruck and Vohra, Shabana and Reynolds, Christopher A and Poyner, David R (2013) 'The activation of the CGRP receptor.' Biochemical Society Transactions, 41 (1). pp. 180-184. ISSN 0300-5127

Taddese, Bruck and Simpson, Lisa M and Wall, Ian D and Blaney, Frank E and Reynolds, Christopher A (2013) 'Modeling Active GPCR Conformations.' G PROTEIN COUPLED RECEPTORS: MODELING, ACTIVATION, INTERACTIONS AND VIRTUAL SCREENING, 522. pp. 21-35. ISSN 0076-6879

Taddese, Bruck and Upton, Graham J G and Bailey, Gregory R and Jordon, Sian R D and Abdalla, Nuradin Y and Reeves, Philip J and Reynolds, Christopher A (2013) 'Structure and functional motifs of GCR1, the only plant protein with a GPCR fold?' Plant Physiology. ISSN 0032-0889

Illingworth, Christopher JR and Chintipalli, Sree V and Serapian, Stefano A and Miller, Andrew D and Veverka, Vaclav and Carr, Mark D and Reynolds, Christopher A (2012) 'The statistical significance of selected sense-antisense peptide interactions.' Journal of Computational Chemistry, 33 (16). pp. 1440-1447. ISSN 0192-8651

Taddese, Bruck and Simpson, Lisa M and Wall, Ian D and Blaney, Frank E and Kidley, Nathan J and Clark, Henry SX and Smith, Richard E and Upton, Graham JG and Gouldson, Paul R and Psaroudakis, George and Bywater, Robert P and Reynolds, Christopher A (2012) 'G-protein-coupled receptor dynamics: dimerization and activation models compared with experiment.' Biochemical Society Transactions, 40 (2). pp. 394-399. ISSN 0300-5127

Simpson, Lisa M and Wall, Ian D and Blaney, Frank E and Reynolds, Christopher A (2011) 'Modeling GPCR active state conformations: The β<sub>2</sub>-adrenergic receptor.' Proteins: Structure, Function, and Bioinformatics, 79 (5). pp. 1441-1457. ISSN 0887-3585

Chintapalli, Sree V and Yew, Boon K and Illingworth, Christopher JR and Upton, Graham JG and Reeves, Philip J and Parkes, Kevin EB and Snell, Christopher R and Reynolds, Christopher A (2010) 'Closed loop folding units from structural alignments: Experimental foldons revisited.' Journal of Computational Chemistry, 31 (15). pp. 2689-2701. ISSN 0192-8651

Illingworth, Christopher JR and Scott, Paul D and Parkes, Kevin EB and Snell, Christopher R and Campbell, Matthew P and Reynolds, Christopher A (2010) 'Connectivity and binding-site recognition: Applications relevant to drug design.' Journal of Computational Chemistry, 31 (15). pp. 2677-2688. ISSN 0192-8651

Simpson, Lisa M and Taddese, Bruck and Wall, Ian D and Reynolds, Christopher A (2010) 'Bioinformatics and molecular modelling approaches to GPCR oligomerization.' Current Opinion in Pharmacology, 10 (1). pp. 30-37. ISSN 1471-4892

Illingworth, Christopher JR and Morris, Garrett M and Parkes, Kevin EB and Snell, Christopher R and Reynolds, Christopher A (2008) 'Assessing the Role of Polarization in Docking.' The Journal of Physical Chemistry A, 112 (47). pp. 12157-12163. ISSN 1089-5639

Illingworth, Christopher JR and Parkes, Kevin EB and Snell, Christopher R and Ferenczy, György G and Reynolds, Christopher A (2008) 'Toward a Consistent Treatment of Polarization in Model QM/MM Calculations.' The Journal of Physical Chemistry A, 112 (47). pp. 12151-12156. ISSN 1089-5639

Illingworth, Christopher JR and Parkes, Kevin E and Snell, Christopher R and Mullineaux, Philip M and Reynolds, Christopher A (2008) 'Criteria for confirming sequence periodicity identified by Fourier transform analysis: Application to GCR2, a candidate plant GPCR?' Biophysical Chemistry, 133 (1-3). pp. 28-35. ISSN 0301-4622

Illingworth, Christopher JR and Parkes, Kevin EB and Snell, Christopher R and Reynolds, Christopher A (2008) 'Quantitative measurement of protease ligand conformation.' Journal of Computer-Aided Molecular Design, 22 (2). pp. 105-109. ISSN 0920-654X

Conference or Workshop Item

Reynolds, Christopher A (2008) COMP 162-Challenging the concept of protein folding units with in vitro folding data. In: UNSPECIFIED, ? - ?.

Reynolds, Christopher A (2008) COMP 360-The class a - class b gpcr alignment. In: UNSPECIFIED, ? - ?.

Reynolds, Christopher A (2008) COMP 381-Enzyme polarization in qm/mm, application to docking and the origin of transition state stabilization in chorismate mutase. In: UNSPECIFIED, ? - ?.

This list was generated on Fri May 27 17:30:43 2022 BST.