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Gundersen, Rebekah Anamarie and Chu, Tianyuan and Abolfathi, Kiana and Gokcen Dogan, Serap and Blair, Phoebe Elizabeth and Nago, Nyasha and Hamblin, Michael and Brooke, Greg Nicholas and Zwacka, Ralf Michael and Kafash Hoshiar, Ali and Mohr, Andrea (2023) Generation of magnetic biohybrid microrobots based on MSC.sTRAIL for targeted stem cell delivery and treatment of cancer. Cancer Nanotechnology, 14 (1). 54-. DOI https://doi.org/10.1186/s12645-023-00203-9

Mohr, Andrea and Chu, Tianyuan and Clarkson, Christopher and Brooke, Greg and Teif, Vladimir and Zwacka, Ralf (2021) Fas-threshold Signalling in MSCs Promotes Pancreatic Cancer Progression and Metastasis. Cancer Letters, 519. pp. 63-77. DOI https://doi.org/10.1016/j.canlet.2021.06.017

Leach, DA and Mohr, A and Giotis, ES and Cil, E and Isac, AM and Yates, LL and Barclay, WS and Zwacka, RM and Bevan, CL and Brooke, GN (2021) The antiandrogen enzalutamide downregulates TMPRSS2 and reduces cellular entry of SARS-CoV-2 in human lung cells. Nature Communications, 12 (1). 4068-. DOI https://doi.org/10.1038/s41467-021-24342-y

Mohr, Andrea and Chu, Tianyuan and Brooke, Greg N and Zwacka, Ralf M (2019) MSC.sTRAIL Has Better Efficacy than MSC.FL-TRAIL and in Combination with AKTi Blocks Pro-Metastatic Cytokine Production in Prostate Cancer Cells. Cancers, 11 (4). p. 568. DOI https://doi.org/10.3390/cancers11040568

Mohr, Andrea and Deedigan, Laura and Jencz, Sylwia and Mehrabadi, Yasamin and Houlden, Lily and Albarenque, Stella-Maris and Zwacka, Ralf M (2018) Caspase-10: a molecular switch from cell-autonomous apoptosis to communal cell death in response to chemotherapeutic drug treatment. Cell Death and Differentiation, 25 (2). pp. 340-352. DOI https://doi.org/10.1038/cdd.2017.164

Mohr, A and Zwacka, RM (2018) The future of mesenchymal stem cell-based therapeutic approaches for cancer – From cells to ghosts. Cancer Letters, 414. pp. 239-249. DOI https://doi.org/10.1016/j.canlet.2017.11.025

Weiher, Hans and Pircher, Haymo and Jansen-Dürr, Pidder and Hegenbarth, Silke and Knolle, Percy and Grunau, Silke and Vapola, Miia and Hiltunen, J Kalervo and Zwacka, Ralf M and Schmelzer, Elmon and Reumann, Kerstin and Will, Hans (2016) A monoclonal antibody raised against bacterially expressed MPV17 sequences shows peroxisomal, endosomal and lysosomal localisation in U2OS cells. BMC Research Notes, 9 (1). 128-. DOI https://doi.org/10.1186/s13104-016-1939-0

Mohr, Andrea and Yu, Rui and Zwacka, Ralf M (2015) TRAIL-receptor preferences in pancreatic cancer cells revisited: Both TRAIL-R1 and TRAIL-R2 have a licence to kill. BMC Cancer, 15 (1). 494-. DOI https://doi.org/10.1186/s12885-015-1508-2

Yu, Rui and Albarenque, Stella Maris and Cool, Robbert H and Quax, Wim J and Mohr, Andrea and Zwacka, Ralf M (2014) DR4 specific TRAIL variants are more efficacious than wild-type TRAIL in pancreatic cancer. Cancer Biology & Therapy, 15 (12). pp. 1658-1666. DOI https://doi.org/10.4161/15384047.2014.972183

Yu, R and Deedigan, L and Albarenque, SM and Mohr, A and Zwacka, RM (2013) Delivery of sTRAIL variants by MSCs in combination with cytotoxic drug treatment leads to p53-independent enhanced antitumor effects. Cell Death & Disease, 4 (2). e503-e503. DOI https://doi.org/10.1038/cddis.2013.19

Büneker, Chirlei Klein and Yu, Rui and Deedigan, Laura and Mohr, Andrea and Zwacka, Ralf Michael (2012) IFN-γ combined with targeting of XIAP leads to increased apoptosis-sensitisation of TRAIL resistant pancreatic carcinoma cells. Cancer Letters, 316 (2). pp. 168-177. DOI https://doi.org/10.1016/j.canlet.2011.10.035

Albarenque, Stella Maris and Zwacka, Ralf Michael and Mohr, Andrea (2011) Both human and mouse mesenchymal stem cells promote breast cancer metastasis. Stem Cell Research, 7 (2). pp. 163-171. DOI https://doi.org/10.1016/j.scr.2011.05.002

Stadel, Dominic and Mohr, Andrea and Ref, Caroline and MacFarlane, Marion and Zhou, Shaoxia and Humphreys, Robin and Bachem, Max and Cohen, Gerry and Möller, Peter and Zwacka, Ralf M and Debatin, Klaus-Michael and Fulda, Simone (2010) TRAIL-Induced Apoptosis Is Preferentially Mediated via TRAIL Receptor 1 in Pancreatic Carcinoma Cells and Profoundly Enhanced by XIAP Inhibitors. Clinical Cancer Research, 16 (23). pp. 5734-5749. DOI https://doi.org/10.1158/1078-0432.ccr-10-0985

Mohr, Andrea and Albarenque, Stella Maris and Deedigan, Laura and Yu, Rui and Reidy, Mairead and Fulda, Simone and Zwacka, Ralf Michael (2010) Targeting of XIAP Combined with Systemic Mesenchymal Stem Cell-Mediated Delivery of sTRAIL Ligand Inhibits Metastatic Growth of Pancreatic Carcinoma Cells. Stem Cells, 28 (11). pp. 2109-2120. DOI https://doi.org/10.1002/stem.533

Zwacka (2009) The TRAIL-receptor-1: TRAIL-receptor-3 and -4 ratio is a predictor for TRAIL sensitivity of cancer cells. Oncology Reports, 21 (5). pp. 1289-1295. DOI https://doi.org/10.3892/or_00000353

Mohr, Andrea and Lyons, Mark and Deedigan, Laura and Harte, Tina and Shaw, Georgina and Howard, Linda and Barry, Frank and O'Brien, Tim and Zwacka, Ralf (2008) Mesenchymal stem cells expressing TRAIL lead to tumour growth inhibition in an experimental lung cancer model. Journal of Cellular and Molecular Medicine, 12 (6b). pp. 2628-2643. DOI https://doi.org/10.1111/j.1582-4934.2008.00317.x

Murray, Thomas VA and McMahon, Jill M and Howley, Breege A and Stanley, Alanna and Ritter, Thomas and Mohr, Andrea and Zwacka, Ralf and Fearnhead, Howard O (2008) A non-apoptotic role for caspase-9 in muscle differentiation. Journal of Cell Science, 121 (22). pp. 3786-3793. DOI https://doi.org/10.1242/jcs.024547

Mohr, A and Büneker, C and Gough, RP and Zwacka, RM (2008) MnSOD protects colorectal cancer cells from TRAIL-induced apoptosis by inhibition of Smac/DIABLO release. Oncogene, 27 (6). pp. 763-774. DOI https://doi.org/10.1038/sj.onc.1210673

Mohr, Andrea and Zwacka, Ralf M (2007) <i>In situ</i> trapping of initiator caspases reveals intermediate surprises. Cell Biology International, 31 (5). pp. 526-530. DOI https://doi.org/10.1016/j.cellbi.2006.11.016

Weiher, H and Zwacka, RM (2007) Vitamin D<inf>3</inf>-24-Hydroxylase (CYP24) as a potential target for intervention with diabetic and nondiabetic nephropathy. Clinical Laboratory, 53 (1-2). pp. 85-88.

La Ferla-Brühl, K and Westhoff, MA and Karl, S and Kasperczyk, H and Zwacka, RM and Debatin, KM and Fulda, S (2007) NF-κB-independent sensitization of glioblastoma cells for TRAIL-induced apoptosis by proteasome inhibition. Oncogene, 26 (4). pp. 571-582. DOI https://doi.org/10.1038/sj.onc.1209841

Braeuer, Susanne J and Büneker, Chirlei and Mohr, Andrea and Zwacka, Ralf Michael (2006) Constitutively Activated Nuclear Factor-κB, but not Induced NF-κB, Leads to TRAIL Resistance by Up-Regulation of X-Linked Inhibitor of Apoptosis Protein in Human Cancer Cells. Molecular Cancer Research, 4 (10). pp. 715-728. DOI https://doi.org/10.1158/1541-7786.mcr-05-0231

Kasperczyk, Hubert and La Ferla-Brühl, Katia and Westhoff, Mike Andrew and Behrend, Lars and Zwacka, Ralf Michael and Debatin, Klaus-Michael and Fulda, Simone (2005) Betulinic acid as new activator of NF-κB: molecular mechanisms and implications for cancer therapy. Oncogene, 24 (46). pp. 6945-6956. DOI https://doi.org/10.1038/sj.onc.1208842

Behrend, Lars and Mohr, Andrea and Dick, Tatjana and Zwacka, Ralf M (2005) Manganese Superoxide Dismutase Induces p53-Dependent Senescence in Colorectal Cancer Cells. Molecular and Cellular Biology, 25 (17). pp. 7758-7769. DOI https://doi.org/10.1128/mcb.25.17.7758-7769.2005

Mohr, Andrea and Zwacka, Ralf Michael and Jarmy, Gergely and Büneker, Chirlei and Schrezenmeier, Hubert and Döhner, Konstanze and Beltinger, Christian and Wiesneth, Markus and Debatin, Klaus-Michael and Stahnke, Karsten (2005) Caspase-8L expression protects CD34+ hematopoietic progenitor cells and leukemic cells from CD95-mediated apoptosis. Oncogene, 24 (14). pp. 2421-2429. DOI https://doi.org/10.1038/sj.onc.1208432

Mohr, A and Henderson, G and Dudus, L and Herr, I and Kuerschner, T and Debatin, K-M and Weiher, H and Fisher, KJ and Zwacka, RM (2004) AAV-encoded expression of TRAIL in experimental human colorectal cancer leads to tumor regression. Gene Therapy, 11 (6). pp. 534-543. DOI https://doi.org/10.1038/sj.gt.3302154

Behrend, L and Henderson, G and Zwacka, RM (2003) Reactive oxygen species in oncogenic transformation. Biochemical Society Transactions, 31 (6). pp. 1441-1444. DOI https://doi.org/10.1042/bst0311441

Stark, LA and Din, FVN and Zwacka, RM and Dunlop, MG (2001) Aspirin‐induced activation of the NF‐κB signaling pathway: a novel mechanism for aspirin‐mediated apoptosis in colon cancer cells. The FASEB Journal, 15 (7). pp. 1273-1275. DOI https://doi.org/10.1096/fj.00-0529fje

Zhou, Weihong and Zhang, Yulong and Hosch, Micaela S and Lang, Amie and Zwacka, Ralf M and Engelhardt, John F (2001) Subcellular Site of Superoxide Dismutase Expression Differentially Controls Ap–1 Activity and Injury in Mouse Liver Following Ischemia/Reperfusion. Hepatology, 33 (4). pp. 902-914. DOI https://doi.org/10.1053/jhep.2001.23073

Zanetti, Michela and Zwacka, Ralph M and Engelhardt, John F and Katusic, Zvonimir S and O’Brien, Timothy (2001) Superoxide Anions and Endothelial Cell Proliferation in Normoglycemia and Hyperglycemia. Arteriosclerosis, Thrombosis, and Vascular Biology, 21 (2). pp. 195-200. DOI https://doi.org/10.1161/01.atv.21.2.195

Zwacka, Ralf M and Stark, Lesley and Dunlop, Malcolm G (2000) NF-?B kinetics predetermine TNF-? sensitivity of colorectal cancer cells. The Journal of Gene Medicine, 2 (5). pp. 334-343. DOI https://doi.org/10.1002/1521-2254(200009/10)2:5<334::aid-jgm129>3.0.co;2-q

Fritz, Eberhard and Friedl, Anna A and Zwacka, Ralf M and Eckardt-Schupp, Friederike and Meyn, M Stephen (2000) The Yeast<i>TEL1</i>Gene Partially Substitutes for Human<i>ATM</i>in Suppressing Hyperrecombination, Radiation-Induced Apoptosis and Telomere Shortening in A-T Cells. Molecular Biology of the Cell, 11 (8). pp. 2605-2616. DOI https://doi.org/10.1091/mbc.11.8.2605

Lam, EWN and Hammad, HM and Zwacka, R and Darby, CJ and Baumgardner, KR and Davidson, BL and Oberley, TD and Engelhardt, JF and Oberley, LW (2000) Immunolocalization and Adenoviral Vector-mediated Manganese Superoxide Dismutase Gene Transfer to Experimental Oral Tumors. Journal of Dental Research, 79 (6). pp. 1410-1417. DOI https://doi.org/10.1177/00220345000790061001

Clozel, Martine and Hess, Patrick and Fischli, Walter and Löffler, Bernd–Michael and Zwacka, Ralf M and Reuter, Alexander and Weiher, Hans (1999) Age-dependent hypertension in Mpv17-deficient mice, a transgenic model of glomerulosclerosis and inner ear disease. Experimental Gerontology, 34 (8). pp. 1007-1015. DOI https://doi.org/10.1016/s0531-5565(99)00074-1

Brown, Michael R and Miller, Francis J and Li, Wei-Gen and Ellingson, Andy N and Mozena, Jonathan D and Chatterjee, Papri and Engelhardt, John F and Zwacka, Ralf M and Oberley, Larry W and Fang, Xiang and Spector, Arthur A and Weintraub, Neal L (1999) Overexpression of Human Catalase Inhibits Proliferation and Promotes Apoptosis in Vascular Smooth Muscle Cells. Circulation Research, 85 (6). pp. 524-533. DOI https://doi.org/10.1161/01.res.85.6.524

Lam, Ernest WN and Zwacka, Ralf and Seftor, Elizabeth A and Nieva, Daniel RC and Davidson, Beverly L and Engelhardt, John F and Hendrix, Mary JC and Oberley, Larry W (1999) Effects of antioxidant enzyme overexpression on the invasive phenotype of hamster cheek pouch carcinoma cells. Free Radical Biology and Medicine, 27 (5-6). pp. 572-579. DOI https://doi.org/10.1016/s0891-5849(99)00109-4

Fan, Chenguang and Zwacka, Ralf M and Engelhardt, John F (1999) Therapeutic approaches for ischemia/reperfusion injury in the liver. Journal of Molecular Medicine, 77 (8). pp. 577-592. DOI https://doi.org/10.1007/s001099900029

Epperly, Michael W and Bray, Jenifer A and Krager, Stephen and Berry, Luann M and Gooding, William and Engelhardt, John F and Zwacka, Ralf and Travis, Elizabeth L and Greenberger, Joel S (1999) Intratracheal injection of adenovirus containing the human MNSOD transgene protects athymic nude mice from irradiation-induced organizing alveolitis. International Journal of Radiation Oncology*Biology*Physics, 43 (1). pp. 169-181. DOI https://doi.org/10.1016/s0360-3016(98)00355-1

Woo, YJ and Zhang, JCL and Vijayasarathy, C and Zwacka, RM and Englehardt, JF and Gardner, TJ and Sweeney, HL (1998) Recombinant adenovirus-mediated cardiac gene transfer of superoxide dismutase and catalase attenuates postischemic contractile dysfunction. Circulation, 98 (19 SUP). II255-II260.

Zwacka, Ralf M and Zhang, Yulong and Zhou, Weihong and Halldorson, Jeff and Engelhardt, John F (1998) Ischemia/reperfusion injury in the liver of BALB/c mice activates AP-1 and nuclear factor κB independently of IκB degradation. Hepatology, 28 (4). pp. 1022-1030. DOI https://doi.org/10.1002/hep.510280417

Reuter, Alexander and Nestl, Andrea and Zwacka, Ralf M and Tuckermann, Jan and Waldherr, Rüdiger and Wagner, Eva-Maria and Höyhtyä, Matti and zum Gottesberge, Angela M Meyer and Angel, Peter and Weiher, Hans (1998) Expression of the Recessive Glomerulosclerosis Gene Mpv17 Regulates MMP-2 Expression in Fibroblasts, the Kidney, and the Inner Ear of Mice. Molecular Biology of the Cell, 9 (7). pp. 1675-1682. DOI https://doi.org/10.1091/mbc.9.7.1675

Fang, Xiang and Weintraub, Neal L and Rios, C David and Chappell, David A and Zwacka, Ralf M and Engelhardt, John F and Oberley, Larry W and Yan, Tao and Heistad, Donald D and Spector, Arthur A (1998) Overexpression of Human Superoxide Dismutase Inhibits Oxidation of Low-Density Lipoprotein by Endothelial Cells. Circulation Research, 82 (12). pp. 1289-1297. DOI https://doi.org/10.1161/01.res.82.12.1289

Zwacka, Ralf M and Dudus, Lorita and Epperly, Michael W and Greenberger, Joel S and Engelhardt, John F (1998) Redox Gene Therapy Protects Human IB-3 Lung Epithelial Cells Against Ionizing Radiation-Induced Apoptosis. Human Gene Therapy, 9 (9). pp. 1381-1386. DOI https://doi.org/10.1089/hum.1998.9.9-1381

Zwacka, Ralf M and Dunlop, Malcolm G (1998) GENE THERAPY FOR COLON CANCER. Hematology/Oncology Clinics of North America, 12 (3). pp. 595-615. DOI https://doi.org/10.1016/s0889-8588(05)70010-1

Zwacka, Ralf M and Zhou, Weihong and Zhang, Yulong and Darby, Christine J and Dudus, Lorita and Halldorson, Jeff and Oberley, Larry and Engelhardt, John F (1998) Redox gene therapy for ischemia/reperfusion injury of the liver reduces AP1 and NF-κB activation. Nature Medicine, 4 (6). pp. 698-704. DOI https://doi.org/10.1038/nm0698-698

Gonzalez-Zulueta, Mirella and Ensz, Lisa M and Mukhina, Galina and Lebovitz, Russell M and Zwacka, Ralf M and Engelhardt, John F and Oberley, Larry W and Dawson, Valina L and Dawson, Ted M (1998) Manganese Superoxide Dismutase Protects nNOS Neurons from NMDA and Nitric Oxide-Mediated Neurotoxicity. The Journal of Neuroscience, 18 (6). pp. 2040-2055. DOI https://doi.org/10.1523/jneurosci.18-06-02040.1998

Epperly, M and Bray, J and Kraeger, S and Zwacka, R and Engelhardt, J and Travis, E and Greenberger, J (1998) Prevention of late effects of irradiation lung damage by manganese superoxide dismutase gene therapy. Gene Therapy, 5 (2). pp. 196-208. DOI https://doi.org/10.1038/sj.gt.3300580

Lam, EWN and Zwacka, R and Engelhardt, JF and Davidson, BL and Domann, FE and Yan, T and Oberley, LW (1997) Adenovirus-mediated manganese superoxide dismutase gene transfer to hamster cheek pouch carcinoma cells. Cancer Research, 57 (24). pp. 5550-5556.

Müller, Marcus and Smolders, Jean WT and Meyer zum Gottesberge, Angela M and Reuter, Alexander and Zwacka, Ralf M and Weiher, Hans and Klinke, Rainer (1997) Loss of auditory function in transgenic Mpv17-deficient mice. Hearing Research, 114 (1-2). pp. 259-263. DOI https://doi.org/10.1016/s0378-5955(97)00175-5

Zwacka, RM and Zhang, Y and Halldorson, J and Schlossberg, H and Dudus, L and Engelhardt, JF (1997) CD4(+) T-lymphocytes mediate ischemia/reperfusion-induced inflammatory responses in mouse liver. Journal of Clinical Investigation, 100 (2). pp. 279-289. DOI https://doi.org/10.1172/jci119533

Schenkel, Johannes and Zwacka, Ralf Michael and Rutenberg, Christiane and Reuter, Alexander and Waldherr, Rüdiger and Weiher, Hans (1995) Functional rescue of the glomerulosclerosis phenotype in Mpv17 mice by transgenesis with the human Mpv17 homologue. Kidney International, 48 (1). pp. 80-84. DOI https://doi.org/10.1038/ki.1995.270

Zwacka, RM and Reuter, A and Pfaff, E and Moll, J and Gorgas, K and Karasawa, M and Weiher, H (1994) The glomerulosclerosis gene Mpv17 encodes a peroxisomal protein producing reactive oxygen species. The EMBO Journal, 13 (21). pp. 5129-5134. DOI https://doi.org/10.1002/j.1460-2075.1994.tb06842.x

Karasawa, M and Zwacka, RM and Reuter, A and Fink, T and Hsieh, CL and Lichter, P and Francke, U and Welher, H (1993) The human homolog of the glomerulosclerosis gene Mpv17: structure and genomic organization. Human Molecular Genetics, 2 (11). pp. 1829-1834. DOI https://doi.org/10.1093/hmg/2.11.1829